Intestinal mucosal permeability of severely underweight and nonmalnourished bangladeshi children and effects of nutritional rehabilitation

Journal of Pediatric Gastroenterology and Nutrition

Volumn 51, Issue 5, 2010, Pages 638-644

  Hossain, Md Iqbal ^a   Nahar, Baitun ^c   Hamadani, Jena D ^a   Ahmed, Tahmeed ^a   Roy, Anjan Kumar ^a   Brown, Kenneth H ^b  

^a INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

food supplementation; intestinal permeability; lactulose mannitol test; nutritional rehabilitation; psychosocial stimulation; severe malnutrition

Indexed keywords

ASCORBIC ACID; FERROUS FUMARATE; IRON; LACTULOSE; MANNITOL; NICOTINAMIDE; PALMITIC ACID; PANTOTHENATE CALCIUM; PYRIDOXINE; RIBOFLAVIN; THIAMINE; VITAMIN D; ZINC; ZINC SULFATE;

ARTICLE; BANGLADESH; CALORIE; CHILD; CHILD GROWTH; CHILD NUTRITION; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DISEASE SEVERITY; FEMALE; GLUCOSE URINE LEVEL; HEALTH EDUCATION; HEALTH PROMOTION; HUMAN; INTESTINE FUNCTION; INTESTINE FUNCTION DISORDER; INTESTINE MUCOSA PERMEABILITY; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; PEDIATRIC REHABILITATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; UNDERWEIGHT; WEIGHT CHANGE;

BANGLADESH; BODY WEIGHT; DIETARY SUCROSE; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFANT; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LACTULOSE; MALE; MALNUTRITION; MANNITOL; THINNESS; WEIGHT GAIN;

EID: 78149273202     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3181eb3128     Document Type: Article

References (27)

1. Lunn PG, Northrop-Clewes CA, Downes RM. Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 1991;338:907-10.
2. Sullivan PB, Lunn PG, Northrop-Clewes C, et al. Persistent diarrhea and malnutrition: the impact of treatment on small bowel structure and permeability. J Pediatr Gastroenterol Nutr 1992;14:208-15.
3. Goto K, Chew F, Torun B, et al. Epidemiology of altered intestinal permeability to lactulose and mannitol in Guatemalan infants. J Pediatr Gastroenterol Nutr 1999;28:282-90.
4. Sullivan PB. Studies of the small intestine in persistent diarrhea and malnutrition: the Gambian experience. J Pediatr Gastroenterol Nutr 2002;34:S11-3.
5. Campbell DI, EliaM,Lunn PG. Growth falteringinrural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 2003;133:1332-8.
6. Sullivan PB, Marsh MN, Mirakian R, et al. Chronic diarrhoea and malnutrition: histology of the intestinal mucosa lesion. J Pediatr Gastroenterol Nutr 1991;12:195-203.
7. Lunn PG. The impact of infection and nutrition on gut function and growth in childhood. Proc Nutr Soc 2000;59:147-54.
8. Menzies IS, Laker MF, Pounder R. Abnormal permeability to sugars in villous atrophy. Lancet 1979;8152:1107-9.
9. Ukabam SO, Homeida MMA, Cooper BT. Small intestinal permeability in normal Sudanese subjects: evidence of tropical enteropathy. Trans R Soc Trop Med Hyg 1986;80:204-7.
10. Behrens RH, Lunn PG, Northrop CA, et al. Factors affecting the integrity of the intestinal mucosa of Gambian children. Am J Clin Nutr 1987;45:1433-41.
11. Elia M, Behrens R, Northrop C, et al. Evaluation of mannitol, lactulose and 51Cr-labelled ethylene-diamine tetra-acetate as markers of intestinal permeability in man. Clin Sci 1987;73:197-204.
12. Laker MF, Menzies IS. Increase in human intestinal permeability following injestion of hypertonic solutions. J Physiol 1977;265:881-94.
13. Fleming SC, Kapembwa MS, Laker MF, et al. Rapid and simultaneous determination of lactulose and mannitol in urine, by HPLC with pulsed amperometric detection, for use in studies of intestinal permeability. Clin Chem 1990;36:797-9.
14. MenziesIS.Transmucosal passageofinert mole culesin health and disease. In: Skadhauge E, Heintze K, eds.IntestinalAbsorption and Secretion. Falk Symposium 36. Lancaster, UK: MTP Press Ltd; 1983:527-43.
15. Willumsen JF, Darling JC, Kitundu JA, et al. Dietary management of acute diarrhoea in children: effect of fermented and amylase-digested weaning foods on intestinal permeability. J Pediatr Gastroenterol Nutr 1997;24:235-41.
16. Zhang Y, Lee B, Thompson M, et al. Lactulose-mannitol intestinal permeability test in children with diarrhea caused by rotavirus and cryptosporidium. Diarrhea Working Group, Peru. J Pediatr Gastroen-terol Nutr 2000;31:16-21.
17. Brewster DR, Manary MJ, Menzies IS, et al. Intestinal permeability in kwashiorkor. Arch Dis Child 1997;76:236-41.
18. Berant M, Khourie M, Menzies IS. Effect of iron deficiency on small intestinal permeability in infants and young children. J Pediatr Gastro-enterol Nutr 1992;14:17-20.
19. Roy SK, Behrens RH, Haider R, et al. Impact of zinc supplementation on intestinal permeability in Bangladeshi children with acute diarrhoea and persistent diarrhoea syndrome. J Pediatr Gastroenterol Nutr 1992;15:289-96.
20. Hossain MI, Nahar B, Ahmed T, et al. Impact of community-based follow-up care, with or without food supplementation and/or psycho-social stimulation, on the recovery of severely underweight Bangladeshi children: a randomized intervention trial. Mal Med J 2009;21:140.
21. Northrop CA, Lunn PG, Behrens RH. Automated enzymatic assays for the determination of intestinal permeability probes in urine. 1. Lactulose and lactose. Clin Chim Acta 1990;187:79-87.
22. World Health Organization. Physical Status. The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series 854. Geneva: World Health Organization; 1995.
23. Lima AA, Brito LF, Ribeiro HB, et al. Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula. J Pediatr Gastroenterol Nutr 2005;40:28-35.
24. Ford RP, Menzies IS, Phillipis AD, et al. Intestinal sugar permeability: relationship to diarrheal disease and small bowel morphology. J Pediatr Gastroenterol Nutr 1985;4:568-74.
25. Barboza JM, Silva TM, Guerrant RL, et al. Measurement of intestinal permeability using mannitol and lactulose in children with diarrheal diseases. Braz J Med Biol Res 1999;32:1499-504.
26. Pires ALG, da Silveira TR, Scholl JG. Relationship between nutritional status and histologic findings in small bowel mucosa of children presenting with diarrhoea of more than 14 days' duration. J Trop Pediatr 1999;45:302-4.
27. Adams A. Intestinal permeability assessment. http://www.doctoraja dams. com/IntestinalPermeabilityLabBuy.html. Accessed October 29, 2008.