Modified hydrolysis kinetics of the active lactone moiety of 10-hydroxycamptothecin by liposomal encapsulation

Pharmaceutical Development and Technology

Volumn 15, Issue 6, 2010, Pages 644-652

  Shi, Kai ^a   Tian, Ye ^a   Jiang, Yanbo ^a   Wang, Lan ^a   Cui, Fude ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

10 hydroxycamptothecin; Hydrolysis kinetics; Liposomes; Plasma pharmacokinetics; Stability

Indexed keywords

10 HYDROXYCAMPTOTHECIN; BUFFER; LACTONE; LIPOSOME;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ENCAPSULATION; EQUILIBRIUM CONSTANT; HALF LIFE TIME; HYDROLYSIS KINETICS; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL DELIVERY; NONHUMAN; PLASMA; PLASMA CLEARANCE; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AREA UNDER CURVE; CAMPTOTHECIN; DRUG STABILITY; HALF-LIFE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIPOSOMES; RABBITS; TIME FACTORS;

EID: 78149272729     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903426526     Document Type: Article

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