Mechanisms Underlying the Cerebral Microvascular Responses to Angiotensin II-Induced Hypertension

Microcirculation

Volumn 17, Issue 8, 2010, Pages 641-649

  Vital, Shantel A ^a   Terao, Satoshi ^a   Nagai, Mutsumi ^a   Granger, D Neil ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Hypertension; Inflammation; Leukocyte endothelial cell adhesion; Stroke

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; LOSARTAN; PADGEM PROTEIN; RANTES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL REACTIVITY; BRAIN BLOOD VESSEL; BRAIN ISCHEMIA; CHIMERA; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPERTENSION; INFLAMMATION; LEUKOCYTE ADHERENCE; MEAN ARTERIAL PRESSURE; MICROSCOPY; MICROVASCULATURE; MOUSE; MUTANT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SALT INTAKE; T LYMPHOCYTE; THROMBOCYTE ADHESION; VENULE; WILD TYPE;

ANGIOTENSIN II; ANIMALS; BLOOD-BRAIN BARRIER; CELL ADHESION; CEREBROVASCULAR CIRCULATION; CHEMOKINE CCL5; HOMEODOMAIN PROTEINS; HYPERTENSION; LEUKOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, VIDEO; MICROVESSELS; P-SELECTIN; PLATELET ADHESIVENESS; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM; T-LYMPHOCYTES; TRANSPLANTATION CHIMERA;

MUS;

EID: 78149255616     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2010.00060.x     Document Type: Article

References (31)

1. Alvarez A, Cerdá-Nicolás M, Naim Abu Nabah Y, Mata M, Issekutz AC, Panés J, Lobb RR, Sanz MJ. Direct evidence of leukocyte adhesion in arterioles by angiotensin II. Blood 104: 402-408, 2004.
2. Chen S, Li G, Zhang W, Wang J, Sigmund CD, Olson JE, Chen Y. Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. Am J Physiol Regul Integr Comp Physiol 297: R1526-R1531, 2009.
3. Crowley SD, Gurley SB, Coffman TM. AT (1) receptors and control of blood pressure: the kidney and more. Trends Cardiovasc Med 17: 30-34, 2007.
4. Crowley SD, Song YS, Sprung G, Griffiths R, Sparks M, Yan M, Burchette JL, Howell DN, Lin EE, Okeiyi B, Stegbauer J, Yang Y, Tharaux PL, Ruiz P. A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension 55: 99-108, 2010.
5. Engelhorn T, Doerfler A, Heusch G, Schulz R. Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats. Neurosci Lett 406: 92-96, 2006.
6. Fleegal-DeMotta MA, Doghu S, Banks WA. Angiotensin II modulates BBB permeability via activation of the AT (1) receptor in brain endothelial cells. J Cereb Blood Flow Metab 29: 640-647, 2009.
7. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 204: 2449-2460, 2007.
8. Herd CM, Page CP. Pulmonary immune cells in health and disease: platelets. Eur Respir J 7: 1145-1160, 1994.
9. Ishikawa M, Sekizuka E, Yamaguchi N, Nakadate H, Terao S, Granger DN, Minamitani H. Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature. Am J Physiol Heart Circ Physiol 292: H2306-H2315, 2007.
10. Ito H, Takemori K, Kawai J, Suzuki T. AT1 receptor antagonist prevents brain edema without lowering blood pressure. Acta Neurochir Suppl 76: 141-145, 2000.
11. Kim JH, Kim HS. Downregulation of angiotensin II-induced 12-lipoxygenase expression and cell proliferation in vascular smooth muscle cells from spontaneously hypertensive rats by CCL5. Korean J Physiol Pharmacol 13: 385-392, 2009.
12. Kitiyakara C, Guzman NJ. Malignant hypertension and hypertensive emergencies. J Am Soc Nephrol 9: 133-142, 1998.
13. Kjeldsen SE, Lyle PA, Kizer JR, Dahlof B, Devereux RB, Julius S, Beevers G, De Faire U, Fyhrquist F, Ibsen H, Kristianson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Snapinn SM, Harris KE, Wedel H. The effects of losartan compared to atenolol on stroke in patients with isolated systolic hypertension and left ventricular hypertrophy. The LIFE study. J Clin Hypertens (Greenwich) 7: 152-158, 2005.
14. Lalor P, Nash GB. Adhesion of flowing leucocytes to immobilized platelets. Br J Haematol 89: 725-732, 1995.
15. Larsson PT, Schwieler JH, Wallén NH. Platelet activation during angiotensin II infusion in healthy volunteers. Blood Coagul Fibrinolysis 11: 61-69, 2000.
16. Mateo T, Abu Nabah YN, Abu Taha M, Mata M, Cerdá-Nicolás M, Proudfoot AE, Stahl RA, Issekutz AC, Cortijo J, Morcillo EJ, Jose PJ, Sanz MJ. Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines. J Immunol 176: 5577-5586, 2006.
17. Mori M, Salter JW, Vowinkel T, Krieglstein CF, Stokes KY, Granger DN. Molecular determinants of the prothrombogenic phenotype assumed by inflamed colonic venules. Am J Physiol Gastrointest Liver Physiol 288: G920-G926, 2005.
18. Nishimura Y, Ito T, Saavedra JM. Angiotensin II AT1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 31: 2478-2486, 2000.
19. Palmantier R, Borgeat P. Transcellular metabolism of arachidonic acid in platelets and polymorphonuclear leukocytes activated by physiological agonists: enhancement of leukotriene B4 synthesis. Adv Exp Med Biol 314: 73-89, 1991.
20. Papademetriou V. Inhibition of the renin-angiotensin-aldosterone system to prevent ischemic and atherothrombotic events. Am Heart J. 157 6(Suppl): S24-S30, 2009.
21. Petnehazy T, Stokes KY, Wood KC, Russell J, Granger DN. Role of blood cell-associated AT1 receptors in the microvascular responses to hypercholesterolemia. Arterioscler Thromb Vasc Biol 26: 313-318, 2006.
22. Piqueras L, Kubes P, Alvarez A, O'Connor E, Issekutz AC, Esplugues JV, Sanz MJ. Angiotensin II induces leukocyte-endothelial cell interactions in vivo via AT(1) and AT(2) receptor-mediated P-selectin upregulation. Circulation 102: 2118-2123, 2000.
23. Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Inves 118: 173-182, 2008.
24. Rojas M, Zhang W, Lee DL, Romero MJ, Nguyen DT, Al-Shabrawey M, Tsai NT, Liou GI, Brands MW, Caldwell RW, Caldwell RB. Role of IL-6 in angiotensin II induced retinal vascular inflammation. Invest Ophthalmol Vis Sci 51: 1709-1718, 2010.
25. Suzuki K, Sugimura K, Hasegawa K, Yoshida K, Suzuki A, Ishizuka K, Ohtsuka K, Honma T, Narisawa R, Asakura H. Activated platelets in ulcerative colitis enhance the production of reactive oxygen species by polymorphonuclear leukocytes. Scand J Gastroenterol 36: 1301-1306, 2001.
26. Terao S, Yilmaz G, Stokes KY, Russell J, Ishikawa M, Kawase T, Granger DN. Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion. Stroke 39: 2560-2570, 2008.
27. Vilela MC, Mansur DS, Lacerda-Queiroz N, Rodrigues DH, Lima GK, Arantes RM, Kroon EG, Da Silva Campos MA, Teixeira MM, Teixeira AL. The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis. Ann N Y Acad Sci 1153: 256-263, 2009.
28. Walther T, Olah L, Harms C, Maul B, Bader M, Hörtnagl H, Schultheiss HP, Mies G. Ischemic injury in experimental stroke depends on angiotensin II. FASEB J 16: 169-176, 2002.
29. Wolf G, Ziyadeh FN, Thaiss F, Tomaszewski J, Caron RJ, Wenzel U, Zahner G, Helmchen U, Stahl RA. Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. J Clin Invest 100: 1047-1058, 1997.
30. Yeo EL, Sheppard JA, Feuerstein IA. Role of P-selectin and leukocyte activation in polymorphonuclear cell adhesion to surface adherent activated platelets under physiologic shear conditions (an injury vessel wall model). Blood 83: 2498-2507, 1994.
31. Yilmaz G, Arumugam TV, Stokes KY, Granger DN. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113: 2105-2112, 2006.