Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs

Journal of Medicinal Chemistry

Volumn 53, Issue 21, 2010, Pages 7573-7586

  Hajjo, Rima ^a   Grulke, Christopher M ^a   Golbraikh, Alexander ^a   Setola, Vincent ^b   Huang, Xi Ping ^b   Roth, Bryan L ^a,b   Tropsha, Alexander ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 FLUOROMELATONIN; ADRENOGLOMERULOTROPIN; CGP 13698; DO 897; FENDILINE; FLUSPIRILENE; METHYLERGOMETRINE; PIM 35; PNU 96415 E; RALOXIFENE; SEROTONIN 2B RECEPTOR; SEROTONIN 2B RECEPTOR AGONIST; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALGORITHMS; BINDING, COMPETITIVE; DATABASES, FACTUAL; DEXFENFLURAMINE; FENFLURAMINE; HEART VALVE DISEASES; LIGANDS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 78149252206     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100600y     Document Type: Article

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