Effectiveness of pharmacist-participated warfarin therapy management: A systematic review and meta-analysis

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 11, 2010, Pages 2418-2427

  Saokaew, S ^a,b   Permsuwan, U ^c   Chaiyakunapruk, N ^b,d,e   Nathisuwan, S ^f   Sukonthasarn, A ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b NARESUAN UNIVERSITY   (Thailand)

^c CHIANG MAI UNIVERSITY   (Thailand)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Anticoagulation clinic; Bleeding; Meta analysis; Pharmacist; Systematic review; Thromboembolism; Warfarin

Indexed keywords

WARFARIN;

ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; CINAHL; CLINICAL TRIAL; CONFIDENCE INTERVAL; DATA BASE; HUMAN; META ANALYSIS; MORTALITY; PHARMACIST; PRIORITY JOURNAL; SYSTEMATIC REVIEW; THROMBOEMBOLISM; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BLOOD COAGULATION; FEMALE; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PHARMACISTS; PHARMACY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; THROMBOEMBOLISM; TREATMENT OUTCOME; WARFARIN;

EID: 78149244834     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.04051.x     Document Type: Article

References (60)

1. Pirmohamed M. Warfarin: almost 60 years old and still causing problems. Br J Clin Pharmacol 2006; 62: 509-11.
2. Wysowski DK, Nourjah P, Swartz L. Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action. Arch Intern Med 2007; 167: 1414-9.
3. Holbrook AM, Pereira JA, Labiris R, McDonald H, Douketis JD, Crowther M, Wells PS. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med 2005; 165: 1095-106.
4. Schulman S, Beyth RJ, Kearon C, Levine MN. Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 257S-98S.
5. Oake N, Jennings A, Forster AJ, Fergusson D, Doucette S, Van Walraven C. Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis. Can Med Assoc J 2008; 179: 235-44.
6. Oake N, Fergusson DA, Forster AJ, Van Walraven C. Frequency of adverse events in patients with poor anticoagulation: a meta-analysis. Can Med Assoc J 2007; 176: 1589-94.
7. Hylek EM, Chang YC, Skates SJ, Hughes RA, Singer DE. Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation. Arch Intern Med 2000; 160: 1612-7.
8. Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 160S-98S.
9. Hope KA, Havrda DE. Subtherapeutic INR values associated with a switch to generic warfarin. Ann Pharmacother 2001; 35: 183-7.
10. Wittkowsky AK. Dietary supplements, herbs and oral anticoa-gulants: the nature of the evidence. J Thromb Thrombolysis 2008; 25: 72-7.
11. Wittkowsky AK. Drug interactions updates: drugs, herbs and oral anticoagulation. J Thromb Thrombolysis 2001; 12: 67-71.
12. McAnulty JH. Barriers to the use of warfarin: potential solutions. J Interv Card Electrophysiol 2004; 10: 17-20.
13. Willey ML, Chagan L, Sisca TS, Chapple KJ, Callahan AK, Crain JL, Kitenko LE, Martin T, Spedden KD. A pharmacist-managed anticoagulation clinic: six-year assessment of patient outcomes. Am J Health Syst Pharm 2003; 60: 1033-7.
14. Davis NJ, Billett HH, Cohen HW, Arnsten JH. Impact of adherence, knowledge, and quality of life on anticoagulation control. Ann Pharmacother 2005; 39: 632-6.
15. Krittathanmakul S, Silapachote P, Pongwecharak J, Wongsatit U. Effects of pharmacist counseling on outpatients receiving warfarin at Songklanagarind Hospital. Songkla Med J 2006; 24: 93-9.
16. Van Walraven C, Jennings A, Oake N, Fergusson D, Forster A. Effect of study setting on anticoagulation control: a systematic review and metaregression. Chest 2006; 129: 1155-66.
17. Cios DA, Baker WL, Sander SD, Phung OJ, Coleman CI. Evaluating the impact of study-level factors on warfarin control in U.S.-based primary studies: a meta-analysis. Am J Health Syst Pharm 2009; 66: 916-25.
18. Baker WL, Cios DA, Sander SD, Coleman CI. Meta-analysis to assess the quality of warfarin control in atrial fibrillation patients in the United States. J Manag Care Pharm 2009; 15: 244-52.
19. Lee YP, Schommer JC. Effect of a pharmacist-managed anticoagulation clinic on warfarin-related hospital readmissions. Am J Health Syst Pharm 1996; 53: 1580-3.
20. Mattaya S, Anusornsangiam W, Kanjanasilp J, Klangsang J. Outcome of pharmaceutical care in anticoagulation clinic at Roi-Et hospital, Roi-Et province, Northeastern Thailand. J Sci Technol MSU 2008; 27: 59-67.
21. Biscup-Horn PJ, Streiff MB, Ulbrich TR, Nesbit TW, Shermock KM. Impact of an inpatient anticoagulation management service on clinical outcomes. Ann Pharmacother 2008; 42: 777-82.
22. Munjamroon Y, Suttajit S, Tammarat T, Saritreechaikun D. Clinical outcomes of warfarin monitoring in outpatients at Nakorn Phanom Hospiatal. J Sci Technol MSU 2007; 26: 38-46.
23. Zed PJ, Filiatrault L. Clinical outcomes and patient satisfaction of a pharmacist-managed, emergency department-based outpatient treatment program for venous thromboembolic disease. CJEM 2008; 10: 10-7.
24. Macik BG. The future of anticoagulation clinics. J Thromb Thrombolysis 2003; 16: 55-9.
25. Schulman S, Kearon C, on behalf of the subcommittee on control of anticoagulation of the Scientific and Standardization committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. Scientific and Standardization Committee Communication. J Thromb Haemost 2005; 3: 692-4.
26. Downs S, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998; 52: 377-84.
27. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12.
28. Hannan EL. Randomized clinical trials and observational studies: guidelines for assessing respective strengths and limitations. JACC Cardiovasc Interv 2008; 1: 211-7.
29. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177-88.
30. Higgins JP, Thompson SG. Quantifying heterogeneity in meta-analysis. Stat Med 2002; 21: 1539-58.
31. Katemateegaroon D. Warfarin Related Problems and Comparison of Patient Outcomes Between Pharmacist-Assisted Anticoagulation Service and Usual Medical Care in Ambulatory Patients. Khon Kaen: Khon Kaen University, 2002.
32. Wilson SJ, Wells PS, Kovacs MJ, Lewis GM, Martin J, Burton E, Anderson DR. Comparing the quality of oral anticoagulant management by anticoagulation clinics and by family physicians: a randomized controlled trial. Can Med Assoc J 2003; 169: 293-8.
33. Jackson SL, Peterson GM, Vial JH, Jupe DML. Improving the outcomes of anticoagulation: an evaluation of home follow-up of warfarin initiation. J Intern Med 2004; 256: 137-44.
34. Chan FWH, Wong RSM, Lau W-H, Chan TYK, Cheng G, You JHS. Management of Chinese patients on warfarin therapy in two models of anticoagulation service - a prospective randomized trial. Br J Clin Pharmacol 2006; 62: 601-9.
35. Lalonde L, Martineau J, Blais N, Montigny M, Ginsberg J, Fournier M, Berbiche D, Vanier M-C, Blais L, Perreault S, Rodrigues I. Is long-term pharmacist-managed anticoagulation service efficient? A pragmatic randomized controlled trial. Am Heart J 2008; 156: 148-54.
36. Cohen IA, Hutchison TA, Kirking DM, Shue ME. Evaluation of a pharmacist-managed anticoagulation clinic. J Clin Hosp Pharm 1985; 10: 167-75.
37. Ellis RF, Stephens MA, Sharp GB. Evaluation of a pharmacy-managed warfarin monitoring service to coordinate inpatient and outpatient therapy. Am J Hosp Pharm 1992; 49: 387-94.
38. Wilt VM, Gums JG, Ahmed OI, Moore LM. Outcome analysis of a pharmacist-managed anticoagulation service. Pharmacotherapy 1995; 15: 732-5.
39. To EK, Pearson GJ. Implementation and evaluation of a pharmacist-assisted warfarin dosing program. Can J Hosp Pharm 1997; 50: 169-75.
40. Chiquette E, Amato MG, Bussey HI. Comparison of an anticoagulation clinic with usual medical care: anticoagulation control, patient outcomes, and health care costs. Arch Intern Med 1998; 158: 1641-7.
41. Bieobanjong S. The Clinical Outcomes of Pharmaceutical Care on Warfarin in Out-Patients at Chiangrai Regional Hospital. Chiang Mai: Chiang Mai University, 2000.
42. Dager WE, Branch JM, King JH, White RH, Quan RS, Musallam NA, Albertson TE. Optimization of inpatient warfarin therapy: impact of daily consultation by a pharmacist-managed anticoagulation service. Ann Pharmacother 2000; 34: 567-72.
43. Tschol N, Lai DSK, Tilley JA, Wong H, Brown GR. Comparison of physician- and pharmacist-managed warfarin sodium treatment in open heart surgery patients. Can J Cardiol 2003; 19: 1413-7.
44. Witt DM, Humphries TL. A retrospective evaluation of the management of excessive anticoagulation in an established clinical pharmacy anticoagulation service compared to traditional care. J Thromb Thrombolysis 2003; 15: 113-8.
45. Burns N. Evaluation of warfarin dosing by pharmacists for elderly medical in-patients. Pharm World Sci 2004; 26: 232-7.
46. Liabthawee W. Impact of Education and Conseling by Clinical Pharmacists on Anticoagulation Therapy in Patients With Mechanical Heart Valves. Bangkok: Mahidol University, 2004.
47. Bond CA, Raehl CL. Pharmacist-provided anticoagulation management in United States hospitals: death rates, length of stay, medicare charges, bleeding complications, and transfusions. Pharmacotherapy 2004; 24: 953-63.
48. Damaske DL, Baird RW. Development and implementation of a pharmacist-managed inpatient warfarin protocol. Proc (Bayl Univ Med Cent) 2005; 18: 397-400.
49. Witt DM, Sadler MA, Shanahan RL, Mazzoli G, Tillman DJ. Effect of a centralized clinical pharmacy anticoagulation service on the outcomes of anticoagulation therapy. Chest 2005; 127: 1515-22.
50. Locke C, Ravnan SL, Patel R, Uchizono JA. Reduction in warfarin adverse events requiring patient hospitalization after implementation of a pharmacist-managed anticoagulation service. Pharmacotherapy 2005; 25: 685-9.
51. Chau T, Rotbard M, King S, Li MM, Leong WA. Implementation and evaluation of a warfarin dosing service for rehabilitation medicine: report from a pilot project. Can J Hosp Pharm 2006; 59: 136-47.
52. Poon IO, Lal L, Brown EN, Braun UK. The impact of pharmacist-managed oral anticoagulation therapy in older veterans. J Clin Pharm Ther 2007; 32: 21-9.
53. Bungard TJ, Gardner L, Archer SL, Hamilton P, Ritchie B, Tymchak W, Tsuyuki RT. Evaluation of a pharmacist-managed anticoagulation clinic: improving patient care. Open Med 2009; 3: 16-21.
54. Airee A, Guirguis AB, Mohammad RA. Clinical outcomes and pharmacists' acceptance of a community hospital's anticoagulation management service utilizing decentralized clinical staff pharmacists. Ann Pharmacother 2009; 43: 621-8.
55. Copas J, Shi JQ. Meta-analysis, funnel plots and sensitivity analysis. Biostatistics 2000; 1: 247-62.
56. Berlin JA. Benefits of heterogeneity in meta-analysis of data from epidemiologic studies. Am J Epidemiol 1995; 142: 383-7.
57. The Cochrane Collaboration. Sensitivity analysis. 2002; Available from: [updated 2002; Accessed 29 July 2009].
58. Deeks JJ, Higgins JP, Altman DG, on behalf of the Cochrane Statistical Methods Group. Analysing data and undertaking meta-analyses. In: Higgins JP, ed. Cochrane Handbook for Systematic Reviews of Interventions. West Sussex, England: John Wiley & Sons Ltd, 2008: 223-96.
59. Beyth RJ, Quinn LM, Landefeld CS. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med 1998; 105: 91-9.
60. McMahan DA, Smith DM, Carey MA, Zhou XH. Risk of major hemorrhage for outpatients treated with warfarin. J Gen Intern Med 1998; 13: 311-6.