Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 42, 2010, Pages 17951-17956

  Schubert, Heidi L ^a   Zhai, Qianting ^a   Sandrin, Virginie ^a   Eckert, Debra M ^a   Garcia Maya, Mitla ^b   Saul, Louise ^b   Sundquist, Wesley I ^a   Steiner, Roberto A ^b   Hill, Christopher P ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Coiled coil; Crystal structures; HIV; Innate immunity; Restriction factor

Indexed keywords

CELL PROTEIN; PROTEIN BST2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REDUCTION;

ANTIGENS, CD; BIOPOLYMERS; CRYSTALLOGRAPHY, X-RAY; GPI-LINKED PROTEINS; HUMANS; OXIDATION-REDUCTION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78149243391     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008206107     Document Type: Article

References (58)

1. Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8(7):559-568.
2. Neil SJD, Zang T, Bieniasz PD (2008) Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 451(7177):425-430.
3. Van Damme N, et al. (2008) The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3(4):245-252.
4. Kaletsky RL, Francica JR, Agrawal-Gamse C, Bates P (2009) Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. Proc Natl Acad Sci USA 106(8):2886-2891.
5. Sakuma T, Noda T, Urata S, Kawaoka Y, Yasuda J (2009) Inhibition of Lassa and Marburg virus production by tetherin. J Virol 83(5):2382-2385.
6. Jouvenet N, et al. (2009) Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol 83(4):1837-1844.
7. Groom HC, Yap MW, Galao RP, Neil SJ, Bishop KN (2010) Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors. Proc Natl Acad Sci USA 107(11):5166-5171.
8. Douglas JL, et al. (2010) The great escape: Viral strategies to counter BST-2/tetherin. PLoS Pathog 6(5):e1000913.
9. Sauter D, Specht A, Kirchhoff F (2010) Tetherin: Holding on and letting go. Cell 141(3):392-398.
10. Arnaud F, et al. (2010) Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses. J Virol 84(9):4415-4425.
11. Neil SJD, Sandrin V, Sundquist WI, Bieniasz PD (2007) An interferon-[alpha]-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe 2(3):193-203.
12. Neil SJD, Eastman SW, Jouvenet N, Bieniasz PD (2006) HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane. PLoS Pathog 2(5):e39.
13. Hammonds J, Wang JJ, Yi H, Spearman P (2010) Immunoelectronmicroscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane. PLoS Pathog 6(2):e1000749.
14. Fitzpatrick K, et al. (2010) Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog 6(3):e1000701.
15. Klimkait T, Strebel K, Hoggan MD, Martin MA, Orenstein JM (1990) The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release. J Virol 64(2):621-629.
16. Göttlinger HG, Dorfman T, Cohen EA, Haseltine WA (1993) Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc Natl Acad Sci USA 90(14):7381-7385.
17. Varthakavi V, Smith RM, Bour SP, Strebel K, Spearman P (2003) Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production. Proc Natl Acad Sci USA 100:15154-15159.
18. Miyagi E, Andrew AJ, Kao S, Strebel K (2009) Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion. Proc Natl Acad Sci USA 106(8):2868-2873.
19. Iwabu Y, et al. (2009) HIV-1 accessory protein Vpu internalizes cell-surface BST-2/ tetherin through transmembrane interactions leading to lysosomes. J Biol Chem 284(50):35060-35072.
20. Schubert U, et al. (1996) Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1- infected cells. FEBS Lett 398(1):12-18.
21. McNatt MW, et al. (2009) Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants. PLoS Pathog 5(2):e1000300.
22. Banning C, et al. (2010) A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells. PLoS One 5(2):e9344.
23. Rong L, et al. (2009) The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu. J Virol 83(15): 7536-7546.
24. Jia B, et al. (2009) Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog 5(5):e1000429.
25. Lim ES, Malik HS, Emerman M (2010) Ancient adaptive evolution of Tetherin shaped Vpu and Nef functions in human immunodeficiency virus and primate lentiviruses. J Virol 84(14):7124-7134.
26. Le Tortorec A, Neil SJ (2009) Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein. J Virol 83(22):11966-11978.
27. Gupta RK, et al. (2009) Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration. Proc Natl Acad Sci USA 106 (49):20889-20894.
28. Zhang F, et al. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host Microbe 6(1):54-67.
29. Yang SJ, et al. (2010) Anti-tetherin activities in Vpu-expressing primate lentiviruses. Retrovirology 7:13.
30. Bartee E, McCormack A, Fruh K (2006) Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog 2(10):e107.
31. Pardieu C, et al. (2010) The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathog 6(4):e1000843.
32. Ohtomo T, et al. (1999) Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Bioph Res Co 258(3):583-591.
33. Kupzig S, et al. (2003) Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Traffic 4(10):694-709. (Pubitemid 37168591)
34. Perez-Caballero D, et al. (2009) Tetherin inhibits HIV-1 release by directly tethering virions to cells. Cell 139(3):499-511.
35. Rollason R, Korolchuk V, Hamilton C, Jepson M, Banting G (2009) A CD317/ tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol 184(5):721-736.
36. Hinz A, et al. (2010) Structural basis of HIV-1 tethering to membranes by the BST-2/ tetherin ectodomain. Cell Host Microbe 7(4):314-323.
37. Sakuma T, Sakurai A, Yasuda J (2009) Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses. PLoS One 4(9):e6934.
38. Crick FH (1953) The packing of ?-helices: Simple coiled-coils. Acta Crystallogr 6:689-697.
39. O'Shea EK, Klemm JD, Kim PS, Alber T (1991) X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254(5031):539-544.
40. Walshaw J, Woolfson DN (2001) Socket: a program for identifying and analysing coiled-coil motifs within protein structures. J Mol Biol 307(5):1427-1450. (Pubitemid 33027651)
41. Zhou NE, Kay CM, Hodges RS (1993) Disulfide bond contribution to protein stability: positional effects of substitution in the hydrophobic core of the two-stranded alpha-helical coiled-coil. Biochemistry 32(12):3178-3187.
42. Garcia P, et al. (2006) Molecular insights into the self-assembly mechanism of dystrophia myotonica kinase. FASEB J 20(8):1142-1151. (Pubitemid 44943910)
43. Dube M, et al. (2010) Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment. PLoS Pathog 6(4):e1000856 (in eng).
44. Feener EP, Shen WC, Ryser HJ (1990) Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomes. J Biol Chem 265(31):18780-18785.
45. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276:307-326. (Pubitemid 27085611)
46. Adams PD, et al. (2010) PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D 66(Pt 2):213-221.
47. Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D 60(Pt 12 Pt 1):2126-2132.
48. Murshudov GN, Vagin AA, Dodson EJ (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D 53(Pt 3):240-255.
49. Steiner RA, Lebedev AA, Murshudov GN (2003) Fisher's information in maximum-likelihood macromolecular crystallographic refinement. Acta Crystallogr D 59(Pt 12): 2114-2124.
50. Painter J, Merritt EA (2006) Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D 62(Pt 4):439-450.
51. CCP4 (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D 50(Pt 5):760-763.
52. Leslie AGW (1992) Recent changes to the MOSFLM package for processing film and image plate data. Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography No. 26:27-33.
53. Evans P (2006) Scaling and assessment of data quality. Acta Crystallogr D 62(Pt 1): 72-82.
54. McCoy AJ, et al. (2007) Phaser crystallographic software. J Appl Crystallogr 40(Pt 4): 658-674.
55. Adams PD, et al. (2002) PHENIX: Building new software for automated crystallographic structure determination. Acta Crystallogr D 58(Pt 11):1948-1954.
56. Praaenikar J, Afonine PV, Guncar G, Adams PD, Turk D (2009) Averaged kick maps: Less noise, more signal... and probably less bias. Acta Crystallogr D 65(Pt 9):921-931.
57. Cole JL (2004) Analysis of heterogeneous interactions. Methods Enzymol 384:212-232.
58. Laue T, Shah B, Ridgeway T, Pelletier S (1992) Computer-aided interpretation of analytical sedimentation data for proteins (Royal Society of Chemistry, Cambridge, UK), pp 90-125.