Pharmacokinetics, pharmacodynamics, and Monte Carlo simulation: Selecting the best antimicrobial dose to treat an infection

Pediatric Infectious Disease Journal

Volumn 29, Issue 11, 2010, Pages 1043-1046

  Bradley, John S ^a,b   Garonzik, Samira Merali ^c,d   Forrest, Alan ^c,d   Bhavnani, Sujata M ^c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RADY CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

^d INSTITUTE FOR CLINICAL PHARMACODYNAMICS   (United States)

Author keywords

antimicrobial; Monte Carlo simulation; pharmacodynamics; pharmacokinetic

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN; AMPICILLIN; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; AREA UNDER THE CURVE; COMPUTER MODEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXPOSURE; DRUG SAFETY; DRUG TISSUE LEVEL; HEALTH CARE SYSTEM; HUMAN; KIDNEY FAILURE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; OTITIS MEDIA; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SHORT SURVEY; STREPTOCOCCAL PHARYNGITIS; STREPTOCOCCUS PYOGENES;

EID: 78149241826     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181f42a53     Document Type: Review

References (14)

1. Bradley JS, et al. Predicting efficacy of antiinfectives.... Pediatr Infect Dis J. 2003;22:982-992.
2. Kearns GL, et al. Developmental pharmacology-drug disposition.... N Engl J Med. 2003;349:1157-1167.
3. Ambrose PG, et al. Pharmacokineticspharmacodynamics of antimicrobial therapy.... Clin Infect Dis. 2007;44:79-86.
4. Drusano GL. Pharmacokinetics and pharmacodynamics of antimicrobials. Clin Infect Dis. 2007;45:S89-S95.
5. Block SL, et al. Pneumococcal serotypes from acute.... Pediatr Infect Dis J. 2002;21:859-865.
6. Aguilar L, et al. Microbiology of the middle ear fluid.... Int J Pediatr Otorhinolaryngol. 2009;73:1407-1411.
7. Porat N, et al. Increasing importance of multidrug-resistant.... Pediatr Infect Dis J. 2010;29:126-130.
8. Craig WA. Basic pharmacodynamics of antibacterials.... Infect Dis Clin North Am. 2003;17:479-501.
9. Lee J, et al. Once daily dosing of amoxicillin.... Paper presented at: the Western States Conference; May 24-25, 2004; Asilomar, CA.
10. Lennon DR, et al. Once-daily amoxicillin versus twice-daily penicillin V.... Arch Dis Child. 2008;93:474-478.
11. Dellit TH, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines.... Clin Infect Dis. 2007;44:159-177.
12. Bhavnani SM, et al. Pharmacokineticspharmacodynamics of quinolones.... Diagn Microbiol Infect Dis. 2008;62:99-101.
13. Craig WA, et al. Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatr Infect Dis J. 1996;15:255-259.
14. Dagan R. The use of pharmacokinetic/pharmacodynamic principles.... Int J Antimicrob Agents. 2007;30:S127-S130.