Invasive ductal carcinomas of the breast showing partial reversed cell polarity are associated with lymphatic tumor spread and may represent part of a spectrum of invasive micropapillary carcinoma

American Journal of Surgical Pathology

Volumn 34, Issue 11, 2010, Pages 1637-1646

  Acs, Geza ^a,b,c,d,e   Esposito, Nicole N ^b,c,e   Rakosy, Zsuzsa ^d   Laronga, Christine ^c   Zhang, Paul J ^f  

^a Ruffolo Hooper and Associates   (United States)

^b Department of Anatomic Pathology ^*  (United States)

^c Women's Oncology Comprehensive Breast Program   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

breast carcinoma; invasive micropapillary carcinoma; lymph node metastasis; lymphatic invasion; reversed cell polarity

Indexed keywords

MUC1 PROTEIN, HUMAN; MUCIN 1; TUMOR MARKER;

ARTICLE; BREAST TUMOR; CANCER INVASION; CELL DIFFERENTIATION; CELL POLARITY; CHEMISTRY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; METASTASIS; MIDDLE AGED; PAGET NIPPLE DISEASE; PAPILLARY CARCINOMA; PATHOLOGY; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDY;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, PAPILLARY; CELL DIFFERENTIATION; CELL POLARITY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; MUCIN-1; NEOPLASM INVASIVENESS; PHENOTYPE; PROGNOSIS; PROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 78049527191     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181f5539c     Document Type: Article

References (40)

1. Acs G, Dumoff KL, Solin LJ, et al. Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma. Am J Surg Pathol. 2007;31:129-140.
2. Acs G, Paragh G, Chuang ST, et al. The presence of micropapillary features and retraction artifact in core needle biopsy material predicts lymph node metastasis in breast carcinoma. Am J Surg Pathol. 2009;33:202-210.
3. Barsky S, Alpaugh M. The molecular basis of inflammatory breast carcinoma [abstract]. Proc Am Assoc Cancer Res. 2002;43:368.
4. Barsky SH, Ye Y, Karlin NJ. "Separation artifact" v lymphovas-cular invasion: are mimics only mimics? [abstract]. Mod Pathol. 2006;19(suppl 1):289A.
5. Clarijs R, Ruiter DJ, de Waal RM. Lymphangiogenesis in malignant tumours: does it occur? J Pathol. 2001;193:143-146.
6. Damiani S, Eusebi V, Peterse JL. Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. Histopathology. 2002;41: 208-215.
7. Gong Y, Sun X, Huo L, et al. Expression of cell adhesion molecules, CD44s and E-cadherin, and microvessel density in invasive micro-papillary carcinoma of the breast. Histopathology. 2005;46:24-30.
8. Hartveit E. Attenuated cells in breast stroma: the missing lymphatic system of the breast. Histopathology. 1990;16:533-543.
9. Hartveit F. Pericytes in human breast stroma and the cells to which they relate. Eur J Morphol. 1992;30:289-296.
10. Hazan RB, Kang L, Whooley BP, et al. N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Commun. 1997;4:399-411.
11. Hazan RB, Phillips GR, Qiao RF, et al. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 2000;148:779-790.
12. Hilkens J, Wesseling J, Vos HL, et al. Involvement of the cell surface-bound mucin, episialin/MUC1, in progression of human carcinomas. Biochem Soc Trans. 1995;23:822-826.
13. Kruslin B, Tomas D, Rogatsch H, et al. Correlation of periacinar retraction clefting in needle core biopsies and corresponding prostatectomy specimens of patients with prostatic adenocarcinoma. Int J Surg Pathol. 2005;13:67-72.
14. Kuroda H, Sakamoto G, Ohnisi K, et al. Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 2004; 11:169-174.
15. Luna-More S, Gonzalez B, Acedo C, et al. Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract. 1994;190:668-674.
16. Madhavan M, Srinivas P, Abraham E, et al. Cadherins as predictive markers of nodal metastasis in breast cancer. Mod Pathol. 2001;14: 423-427.
17. Middleton LP, Tressera F, Sobel ME, et al. Infiltrating micro-papillary carcinoma of the breast. Mod Pathol. 1999;12:499-504.
18. Nagi C, Guttman M, Jaffer S, et al. N-cadherin expression in breast cancer: correlation with an aggressive histologic variantFinvasive micropapillary carcinoma. Breast Cancer Res Treat. 2005;94:225-235.
19. Nassar H. Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol. 2004;11: 297-303.
20. Nassar H, Wallis T, Andea A, et al. Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma. Mod Pathol. 2001;14:836-841.
21. Nassar H, Pansare V, Zhang H, et al. Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol. 2004;17:1045-1050.
22. Nieman MT, Prudoff RS, Johnson KR, et al. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 1999;147:631-644.
23. Page DL, Anderson TJ, Sakamoto G. Infiltrating carcinoma: major histologic types. In: Page DL, Anderson TJ, eds. Diagnostic Histopathology of the Breast. London: WB Saunders; 1987:193-235.
24. Paragh G, Xu X, Pasha T, et al. The extent of retraction artifact correlates with lymphatic vessel density and VEGF-C expression in early stage breast carcinoma and predicts the presence of nodal metastasis [abstract]. Mod Pathol. 2008;21:48A-49A.
25. Paterakos M, Watkin WG, Edgerton SM, et al. Invasive micro-papillary carcinoma of the breast: a prognostic study. Hum Pathol. 1999;30:1459-1463.
26. Pepper MS. Lymphangiogenesis and tumor metastasis: myth or reality? Clin Cancer Res. 2001;7:462-468.
27. Petersen JL. Breast carcinomas with an unexpected inside out growth pattern. Rotation of polarization associated with angioinva-sion [abstract]. Pathol Res Pract. 1993;189:780.
28. Pettinato G, Manivel CJ, Panico L, et al. Invasive micropapillary carcinoma of the breast: clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior. Am J Clin Pathol. 2004;121:857-866.
29. Pinder SE, Elston CW, Ellis IO. Invasive carcinoma-usual histologic types. In: Elston CW, Ellis IO, eds. The Breast. Edinburgh: Churchill Livingstone; 1998:283-337.
30. Siitonen SM, Kononen JT, Helin HJ, et al. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer. Am J Clin Pathol. 1996;105:394-402.
31. Sleeman JP. The lymph node as a bridgehead in the metastatic dissemination of tumors. Recent Results Cancer Res. 2000;157:55-81.
32. Stacker SA, Achen MG, Jussila L, et al. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer. 2002;2:573-583.
33. Stacker SA, Baldwin ME, Achen MG. The role of tumor lymphangiogenesis in metastatic spread. Faseb J. 2002;16:922-934.
34. Varga Z, Zhao J, Ohlschlegel C, et al. Preferential HER-2/neu overexpression and/or amplification in aggressive histological subtypes of invasive breast cancer. Histopathology. 2004;44:332-338.
35. Varma M, Lee MW, Tamboli P, et al. Morphologic criteria for the diagnosis of prostatic adenocarcinoma in needle biopsy specimens. A study of 250 consecutive cases in a routine surgical pathology practice. Arch Pathol Lab Med. 2002;126:554-561.
36. Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 1986;17:185-191.
37. Walsh MM, Bleiweiss IJ. Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol. 2001; 32:583-589.
38. Wesseling J, van der V, Vos HL, et al. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol. 1995;129:255-265.
39. Wesseling J, van der V, Hilkens J. A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol Biol Cell. 1996;7:565-577.
40. Zekioglu O, Erhan Y, Ciris M, et al. Invasive micropapillary carcinoma of the breast: high incidence of lymph node metastasis with extranodal extension and its immunohistochemical profile compared with invasive ductal carcinoma. Histopathology. 2004; 44:18-23.