Apocynin attenuates pressure overload-induced cardiac hypertrophy in rats by reducing levels of reactive oxygen species

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 7, 2010, Pages 745-752

  Liu, Jinjun ^a   Zhou, Juan ^a   An, Wenjiao ^a   Lin, Yuanxi ^a   Yang, Yang ^a   Zang, Weijin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Angiotensin II; Apocynin; Cardiac hypertrophy; NADPH oxidase; Reactive oxygen species

Indexed keywords

ANGIOTENSIN II; APOCYNIN; ATRIAL NATRIURETIC FACTOR; CAPTOPRIL; GLUTATHIONE; GLUTATHIONE DISULFIDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P22PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P67PHOX; SUPEROXIDE; UNCLASSIFIED DRUG; ACETOPHENONE DERIVATIVE; ANTIOXIDANT; ATRIAL NATRIURETIC PEPTIDE, RAT; ENZYME INHIBITOR; NEUTROPHIL CYTOSOL FACTOR 67K; P22 PHOX PROTEIN, RAT; P22-PHOX PROTEIN, RAT; PHOSPHOPROTEIN; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA CONSTRICTION; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; CARDIOMEGALY; DRUG ANTAGONISM; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACETOPHENONES; ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; ATRIAL NATRIURETIC FACTOR; BASE SEQUENCE; CAPTOPRIL; CARDIOMEGALY; DNA PRIMERS; ENZYME INHIBITORS; MALE; NADPH OXIDASE; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 78049502170     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-063     Document Type: Article

References (33)

1. Ahmad, M., White, R., Tan, J., Huang, B.S., and Leenen, F.H. 2008. Angiotensin-converting enzyme inhibitors, inhibition of brain and peripheral angiotensin-converting enzymes, and left ventricular dysfunction in rats after myocardial infarction. J. Cardiovasc. Pharmacol. 51(6): 565-572. doi:10.1097/FJC.0b013e318177090d. PMID:18496146.
2. Bao, W., Behm, D.J., Nerurkar, S.S., Ao, Z., Bentley, R., Mirabile, R.C., et al. 2007. Effects of p38 MAPK inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production. J. Cardiovasc. Pharmacol. 49(6):362-368. doi:10.1097/FJC.0b013e318046f34a. PMID:17577100.
3. Boccanelli, A., and Battagliese, A. 2006. Effects of aldosterone receptor blocker therapy on cardiac remodeling. G. Ital. Nefrol. 23(Suppl 34): S57-S63.[In Italian.] PMID:16633997.
4. Byrne, J.A., Grieve, D.J., Bendall, J.K., Li, J.M., Gove, C., Lambeth, J.D., et al. 2003. Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy, Circ.Res. 93(9): 802-805. doi:10.1161/01.RES.0000099504.30207.F5. PMID:14551238.
5. Cave, A., Grieve, D., Johar, S., Zhang, M., and Shah, A.M. 2005. NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360(1464): 2327-2334. doi:10.1098/rstb.2005.1772. PMID:16321803.
6. Choudhary, R., Baker, K.M., and Pan, J. 2008. All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis. J. Cell. Physiol. 215(1): 172-181. doi:10.1002/jcp.21297.PMID:17941088.
7. Courtois, E., Marques, M., Barrientos, A., Casado, S., and LópezFarré, A. 2003. Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2. J. Am. Soc. Nephrol. 14(6): 1464-1470. doi:10.1097/01.ASN.0000064947.14997.69.PMID:12761246.
8. Csont, T., Viappiani, S., Sawicka, J., Slee, S., Altarejos, J.Y., Batinić-Haberle, I., and Schulz, R. 2005. The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines, J.Mol.Cell.Cardiol. 39(5): 833-840. doi:10.1016/j.yjmcc.2005.07.010. PMID:16171809.
9. de Resende, M.M., and Mill, J.G. 2007. Effect of high salt intake on local renin-angiotensin system and ventricular dysfunction following myocardial infarction in rats. Clin. Exp. Pharmacol. Physiol. 34(4): 274-279.PMID:17324137.
10. Doerries, C., Grote, K., Hilfiker-Kleiner, D., Luchtefeld, M., Schaefer, A., Holland, S.M., et al. 2007. Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction, Circ.Res. 100(6): 894-903. doi:10.1161/01.RES.0000261657.76299.ff. PMID:17332431.
11. Heumuller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H.H.H.W., Busse, R., Schroder, K., and Brandes, R.P. 2008. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension, 51(2): 211-217. doi:10.1161/hypertensionaha.107. 100214. PMID:18086956.
12. Hingtgen, S.D., Tian, X., Yang, J., Dunlay, S.M., Peek, A.S., Wu, Y., et al. 2006. Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy, Physiol.Genomics, 26(3): 180-191. doi:10.1152/ physiolgenomics.00029.2005. PMID:16670255.
13. Johar, S., Cave, A.C., Narayanapanicker, A., Grieve, D.J., and Shah, A.M. 2006. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J. 20(9): 1546-1548. doi:10.1096/fj.05-4642fje.PMID:16720735.
14. Kobayashi, A., Ishikawa, K., Matsumoto, H., Kimura, S., Kamiyama, Y., and Maruyama, Y. 2007. Synergetic antioxidant and vasodilatory action of carbon monoxide in angiotensin II-induced cardiac hypertrophy. Hypertension, 50(6): 1040-1048.doi:10.1161/hypertensionaha.107.097006. PMID:17923586.
15. Kumar, R., Singh, V.P., and Baker, K.M. 2008. The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr. Opin. Nephrol. Hypertens. 17(2): 168-173. doi:10. 1097/MNH.0b013e3282f521a8. PMID:18277150.
16. Lachance, D., Plante, E., Roussel, E., Drolet, M.C., Couet, J., and Arsenault, M. 2008. Early left ventricular remodeling in acute severe aortic regurgitation: insights from an animal model. J. Heart Valve Dis. 17(3): 300-308.PMID:18592927.
17. Li, J.M., Gall, N.P., Grieve, D.J., Chen, M., and Shah, A.M. 2002. Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension, 40(4): 477-484.doi:10.1161/ 01.HYP.0000032031.30374.32. PMID:12364350.
18. Liu, H.G., Liu, K., Zhou, Y.N., and Xu, Y.J. 2008. Effect of NADPH oxidase activity inhibitor apocynin on blood pressure in rats exposed to chronic intermittent hypoxia and thepossible mechanisms, Zhonghua Jie He He Hu Xi Za Zhi, 31(12): 921-925.[In Chinese.] PMID:19134410.
19. Maytin, M., Siwik, D.A., Ito, M., Xiao, L., Sawyer, D.B., Liao, R., and Colucci, W.S. 2004. Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation, 109(9): 1168-1171. doi:10.1161/01.CIR.0000117229.60628.2F.PMID:14981002.
20. Pagano, P.J., Clark, J.K., Cifuentes-Pagano, M.E., Clark, S.M., Callis, G.M., and Quinn, M.T. 1997. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc. Natl. Acad. Sci. U.S.A. 94(26): 14483-14488. doi:10.1073/pnas.94.26.14483.PMID:9405639.
21. Papparella, I., Ceolotto, G., Montemurro, D., Antonello, M., Garbisa, S., Rossi, G., and Semplicini, A. 2008. Green tea attenuates angiotensin II-induced cardiac hypertrophy in rats by modulating reactive oxygen species production and the Src/epidermal growth factor receptor/Akt signaling pathway. J. Nutr. 138(9): 1596-1601PMID:18716156.
22. Paravicini, T.M., and Touyz, R.M. 2006. Redox signaling in hypertension, Cardiovasc.Res. 71(2): 247-258. doi:10.1016/j.cardiores.2006.05.001. PMID:16765337.
23. Qin, F., Simeone, M., and Patel, R. 2007. Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction, FreeRadic.Biol.Med. 43(2): 271-281. doi:10.1016/j. freeradbiomed.2007.04.021. PMID:17603936.
24. Quinn, M.T., and Gauss, K.A. 2004. Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J. Leukoc. Biol. 76(4): 760-781. doi:10.1189/jlb. 0404216. PMID:15240752.
25. Riganti, C., Costamagna, C., Bosia, A., and Ghigo, D. 2006. The NADPH oxidase inhibitor apocynin (acetovanillone) inducesoxidative stress, Toxicol.Appl.Pharmacol. 212(3): 179-187.doi:10.1016/j.taap.2005.07.011. PMID:16120450.
26. Schluter, T., Steinbach, A.C., Steffen, A., Rettig, R., and Grisk, O. 2008. Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition, Cardiovasc.Res. 80(2): 271-279. doi:10.1093/cvr/cvn185. PMID:18596059.
27. Sun, Y., Zhang, J., Zhang, J.Q., and Weber, K.T. 2001. Renin expression at sites of repair in the infarcted rat heart. J. Mol. Cell. Cardiol. 33(5): 995-1003. doi:10.1006/jmcc.2001.1365. PMID:11343421.
28. Tian, N., Moore, R.S., Phillips, W.E., Lin, L., Braddy, S., Pryor, J.S., et al. 2008. NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R1858-R1865.
29. Uechi, M., Tanaka, Y., Aramaki, Y., Hori, Y., Ishikawa, Y., Ebisawa, T., and Yamano, S. 2008. Evaluation of the reninangiotensin system in cardiac tissues of cats with pressure-overload cardiac hypertrophy. Am. J. Vet. Res. 69(3): 343-348.doi:10. 2460/ajvr.69.3.343. PMID:18312132.
30. Ushio-Fukai, M., Zafari, A.M., Fukui, T., Ishizaka, N., and Griendling, K.K. 1996. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J. Biol. Chem. 271(38): 23317-23321. doi:10.1074/jbc.271.38.23317. PMID:8798532.
31. Yu, J., Weïwer, M., Linhardt, R.J., and Dordick, J.S. 2008. The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases. Curr. Vasc. Pharmacol. 6(3): 204-217. doi:10.2174/157016108784911984. PMID:18673160.
32. Zhang, R., Crump, J., and Reisin, E. 2003. Regression of left ventricular hypertrophy is a key goal of hypertension management. Curr. Hypertens. Rep. 5(4): 301-308. doi:10.1007/s11906-003-0038-5. PMID:12844464.
33. Zuo, L., Ushio-Fukai, M., Ikeda, S., Hilenski, L., Patrushev, N., and Alexander, R.W. 2005. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy, Arterioscler.Thromb.Vasc.Biol. 25(9): 1824-1830. doi:10.1161/01.ATV.0000175295.09607.18. PMID:15976327.