Efficacy of local rifampin/minocycline delivery (AIGISRX®) to eliminate biofilm formation on implanted pacing devices in a rabbit model

International Journal of Artificial Organs

Volumn 33, Issue 9, 2010, Pages 627-635

  Hansen, Linda K ^a   Berg, Kim ^a   Johnson, Dave ^a   Sanders, Mark ^b   Citron, Mark ^c  

^a WUXI APPTEC   (China)

^b UNIVERSITY OF MINNESOTA   (United States)

^c TYRX Inc ^*  (United States)

Author keywords

Biofilm; Device; Infection

Indexed keywords

BIOLOGICAL MATERIALS; CONFOCAL MICROSCOPY; ESCHERICHIA COLI; IMPLANTS (SURGICAL); SCANNING ELECTRON MICROSCOPY;

ANTI-BACTERIAL; BACTERIAL BIOFILM; BACTERIAL ENVELOPES; BIOFILM FORMATION; DEVICE SURFACES; INFECTION; MINOCYCLINE; RABBIT MODELS; SUBCUTANEOUS IMPLANTS; SURGICAL INTERVENTIONS;

BIOFILMS;

AIGIS RX; MINOCYCLINE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL HEART PACEMAKER; BACTERIAL VIABILITY; BACTERIUM ADHERENCE; BACTERIUM DETECTION; BIOFILM; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DEVICE; DEVICE INFECTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ESCHERICHIA COLI; EXPERIMENTAL MODEL; NONHUMAN; RABBIT; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS CAPITIS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 78049468662     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139881003300908     Document Type: Article

References (27)

1. Karchmer AW, Longworth DL. Infections of intracardiac devices. Infect Dis Clin North Am 2002; 16: 477-505.
2. Voigt A, Shalaby A, Saba S. Rising Rates of Cardiac Rhythm Management Device Infections in the United States. JACC 2006; 48: 590-91.
3. Giamarellou H. Nosocomial cardiac infections. J Hosp Infect 2002; 50: 91-105.
4. Baddour LM. Nonvalvular cardiovascular device-related infections. Circulation 2004; 108: 2015-31.
5. Tarakji KG, Chan EJ, Cantillon DJ, et al. Cardiac implantable electronic device infections: Presentation, management and patient outcomes. Heart Rhythm 2010; 7: 1043-7.
6. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284: 1318-22.
7. Sampedro MP, Huddleston M, Piper KE, et al. A biofilm approach to detect bacteria on removed spinal implants. Spine 2010; 35: 1218-24.
8. Parsek M, Singh PK. Bacterial Biofilms: An Emerging Link to Disease Pathogenesis. Annual Review Microbiol 2003; 57: 677-701.
9. Wolcott R, Ehrlich GD. Biofilms and Chronic Infections. JAMA 2008; 299: 2682-4.
10. Darouiche RO, Mansouri MD, Zakarevicz D, Alsharif A, Landon GC. In vivo efficacy of antimicrobial-coated devices. J Bone Joint Surg (Am) 2007; 89: 792-7.
11. Hansen LK, Brown M, Johnson D, Palme DF, Love C, Darouiche R. In vivo model of human pathogen infection and demonstration of efficacy by an antimicrobial pouch for pacing devices. PACE 2009; 32: 898-907.
12. Bernthal, NM, Stavrakis AI, Billi F, et al. A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS ONE. (in press)
13. Darouiche RO, Mansouri MD, Raad II. Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal model. Urology 2002; 59: 303-7.
14. Darouiche RO, Mansouri MD. In vitro activity and in vivo efficacy of antimicrobial-coated vascular grafts. Ann Vasc Surg 2004; 18: 497-501.
15. Darouiche RO, Netscher DT, Mansouri MD, Meade R. Activity of antimicrobial-impregnated silicone tissue expanders. Ann Plast Surg 2002; 49: 567-71.
16. Raad I, Darouiche R, Dupuis J, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. Ann Intern Med 1997; 127: 267-74.
17. Agostinho A, James G, Wazni O, Citron M, Wilkoff BD. Inhibition of Staphylococcus aureus biofilms by a novel antibacterial envelope for use with implantable cardiac devices. CTS Journal 2009; 2: 193-8.
18. Kobayashi H, Oethinger M, Tuohy MF, Procop GW, Bauer TW. Improved detection of biofilm-formative bacteria by vortexing and sonication: A pilot study. Clin Orthop Rel Res 2009; 467: 1360-4.
19. Hazan, Z, Zumeris J, Jacob H, et al. Effective prevention of microbial biofilm formation on medical devices by low-energy surface acoustic waves. Antimicrobial Agents & Chemo 2006; 50: 4144-52.
20. Monroe, D. Looking for Chinks in the Armor of Bacterial Biofilms. PLoSBiology 2007; 5: 2458.
21. Da Costa A, Kirkorian G, Cucherat M, et al. Antibiotic prophylaxis for permanent pacemaker implantation: A metaanalysis. Circulation 1998; 97: 1796-1801.
22. Darouiche, RO, Hampel OZ, Boone TB, Raad II. Antimicrobial activity and durability of a novel antimicrobial-impregnated bladder catheter. Inter Jrl Antimicrob Agents 1997; 8: 243-7.
23. Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. Jrl Infect Dis 1996; 173: 418-24.
24. Raad I, Alrahwan A, Rolston K. Staphylococcus epidermis: Emerging resistance and need for alternative agents. Clin Infect Dis 1998; 26: 1182-7.
25. Raad I, Darouiche R, Hachem R, Sacilowski M, Bodey GP. Antibiotics and prevention of microbial colonization of catheters. Antimicrob Agents Chemother 1995; 39: 2397-400.
26. Chatzinikolaou I, Hanna H, Graviss L, et al. Clinical experience with minocycline and rifampin-impregnated central venous catheters in bone marrow transplantation recipients: Efficacy and low risk of developing staphylococcal resistance. Infect Control and Hosp Epidemiol 2003; 24: 961-3.
27. Campoccia D, Montanaro L, Speziale P, Arciola CR. Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials 2010: 31: 6363-77.