Discovery of a novel one-step RuO4-catalysed tandem oxidative polycyclization/double spiroketalization process. Access to a new type of polyether bis-spiroketal compound displaying antitumour activity

Tetrahedron

Volumn 66, Issue 48, 2010, Pages 9370-9378

  Piccialli, Vincenzo ^a   Zaccaria, Sabrina ^a   Borbone, Nicola ^a   Oliviero, Giorgia ^a   D'Errico, Stefano ^a   Hemminki, Akseli ^b   Cerullo, Vincenzo ^b   Romano, Valentina ^b   Tuzi, Angela ^a   Centore, Roberto ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Antitumor activity; C30 polyether bis spiroketals; Double oxidative spyroketalization; Oxidative pentacyclization; RuO4; Squalene

Indexed keywords

POLYETHER BIS SPIROKETAL COMPOUND; RUTHENIUM DERIVATIVE; RUTHENIUM TETROXIDE; SPIRO COMPOUND; SQUALENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATALYSIS; CHEMICAL MODIFICATION; CYCLIZATION; CYTOTOXICITY; DOUBLE OXIDATIVE SPIROKETALIZATION; OXIDATION; PRIORITY JOURNAL;

EID: 78049466658     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.10.004     Document Type: Article

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