Neonatal Exposure to Citalopram Selectively Alters the Expression of the Serotonin Transporter in the Hippocampus: Dose-Dependent Effects

Anatomical Record

Volumn 293, Issue 11, 2010, Pages 1920-1932

  Weaver, Kristin J ^a   Paul, Ian A ^b   Lin, Rick C S ^a,b   Simpson, Kimberly L ^a,b  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant; Development; Dorsal raphe; Reuptake inhibitor; Serotonin

Indexed keywords

CITALOPRAM; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; CAUDATE NUCLEUS; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; FOREBRAIN; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; NONHUMAN; PERINATAL DRUG EXPOSURE; PRIORITY JOURNAL; PUP (RODENT); PUTAMEN; RAPHE NUCLEUS; RAT; THALAMUS VENTRAL NUCLEUS;

ANIMALS; ANIMALS, NEWBORN; CAUDATE NUCLEUS; CEREBRAL CORTEX; CITALOPRAM; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HIPPOCAMPUS; MODELS, ANIMAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PUTAMEN; RATS; RATS, LONG-EVANS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; VENTRAL THALAMIC NUCLEI;

RATTUS; RODENTIA;

EID: 78049465427     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21245     Document Type: Article

References (46)

1. American Academy of Pediatrics Committee on Drugs. 2000. Use of psychoactive medication during pregnancy and possible effects on the fetus and newborn. Pediatrics 105: 880-887.
2. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. 2004. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306: 879-881.
3. Azmitia EC. 2001. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56: 413-424.
4. Bayer SA, Altman J, Russo RJ, Zhang X. 1993. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 14: 83-144.
5. Bennett-Clarke CA, Chiaia NL, Rhoades RW. 1996. Thalamocortical afferents in rat transiently express high-affinity serotonin uptake sites. Brain Res 733: 301-306.
6. Bjerkenstedt L, Flyckt L, Overo KF, Lingjaerde O. 1985. Relationship between clinical effects, serum drug concentration and serotonin uptake inhibition in depressed patients treated with citalopram. A double-blind comparison of three dose levels. Eur J Clin Pharmacol 28: 553-557.
7. Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, Gaspar P. 1996. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: a role of a serotonin excess during the critical period. Neuron 16: 297-307.
8. Casper RC, Fleisher BE, Lee-Ancajas JC, Gilles A, Gaylor E, DeBattista A. 2003. Follow-up of children of depressed mothers exposed or not to antidepressant drugs during pregnancy. J Pediatr 142: 402-408.
9. Chambers CD, Hernandez-Diaz S, Van Marter LJ, Werler MM, Louik C, Jones KL, Mitchell AA. 2006. Selective serotonin reuptake inhibitors and risk of persistant pulmonary hypertension of the newborn. N Engl J Med 354: 579-587.
10. Chambers CD, Johnson KA, Dick LM, Felix RJ, Jones KL. 1996. Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 335: 1010-1015.
11. Clancy B, Darlington RB, Finlay BL. 2001. Translating developmental time across mammalian species. Neuroscience 105: 7-17.
12. Cohen LS, Nonacs R, Viguera AC, Reminick A. 2004. Diagnosis and treatment of depression during pregnancy. CNS Spectra 9: 209-216.
13. D'Amato RI, Blue ME, Largent BL, Lynch DR, Ledbetter DJ, Molliver ME, Synder SH. 1987. Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci USA 84: 4322-4326.
14. Dreyer J, Schleicher M, Tappe A, Schilling K, Kuner T, Kusumawidijaja G, Muller-Esterl W, Oess S, Kuner R. 2004. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. J Neurosci 24: 10454-10465.
15. Esaki T, Cook M, Shimoji K, Murphy DL, Sokoloff L, Holmes A. 2005. Developmental disruption of serotonin tranporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci USA 102: 5582-5587.
16. Federal Drug Administration. 2005. Adverse risk of birth defects with Paxil. Available at: http://www.fda.gov/bbs/topics/NEWS/2005/NEW01270.html
17. Gaspar P, Cases O, Maroteaux L. 2003. The developmental roles of serotonin: news from mouse molecular genentics. Nat Rev Neurosci 4: 1002-1012.
18. Hansen HH, Sanchez C, Meier E. 1997. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? J Pharmacol Exp Ther 283: 1333-1341.
19. Hendrick V, Stowe ZN, Altshuler LL, Hwang S, Lee E, Haynes D. 2003. Placental passage of antidepressant medications. Am J Psychiatry 160: 993-996.
20. Holmes A, Murphy DL, Crawley JN. 2003. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 54: 953-959.
21. Hostetter A, Ritchie JC, Stowe ZN. 2000. Amniotic fluid and umbilical cord blood concentrations of antidepressants in three women. Biol Psychiatry 48: 1032-1034.
22. Imai H, Steindler DA, Kitai ST. 1986. The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J Comp Neurol 243: 363-380.
23. Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ. 2001. Neuropathology of mice carrying mutant APPswe and/or PS1M146L transgenes: alterations in the p75NTR cholinergic basal forebrain septohippocampal pathway. Exp Neurol 171: 227-243.
24. Kirifides ML, Simpson KL, Lin RCS, Waterhouse BD. 2001. Topographic organization and neurochemical identity of dorsal raphe neurons that project to the trigeminal somatosensory pathway in the rat. J Comp Neurol 435: 325-340.
25. Kosofsky BE, Molliver ME. 1987. The serotonergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1: 153-168.
26. Lauder JM. 1990. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann N Y Acad Sci 600: 297-313.
27. LeBrand C, Cases O, Wehrle R, Blakely RD, Edwards RH, Gaspar P. 1998. Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol 401: 506-524.
28. Lu Y, Weaver KJ, Lin RCS, Simpson KL. 2007. Regionally specific co-expression of serotonin and nitric oxide in the rat raphe complex: comparisons between cortically-projecting and descending subgroups. Soc Neurosci Abst 780: 14.
29. Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RCS, Paul IA. 2006. Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Neuropsychopharmacology 31: 47-57.
30. Mamounas LA, Molliver ME. 1988. Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Exp Neurol 102: 23-36.
31. Mendels J, Fabre L, Kiev A. 1990. A double-blind placebo controlled study of citalopram in major depressive disorder. Presented at the 30th annual meeting of the New Clinical Drug Evaluation Unit. Florida, May 29-June 1, 1990.
32. Meyer JH, Wilson AA, Ginovart N, Goulding V, Hussey D, Hood K, Houle S. 2001. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET Imaging Study. Am J Psychiatry 158: 1843-1849.
33. Mirmiran M, van de Poll NE, Corner MA, van Oyen HG, Bour HL. 1981. Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: effects upon adult sleep and behavior in the rat. Brain Res 204: 129-146.
34. Molliver ME. 1987. Serotonergic neuronal systems: what the anatomic organization tells us about function. J Clin Psychopharmacol 7: 3-23.
35. Pastuszak A, Schick-Boschetto B, Zuber C, Feldkamp M, Pinelli M, Sihn S, Donnenfeld A, McCormack M, Leen-Mitchel M, Woodland C, Gardner G, Horn M, Koren G. 1993. Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac). JAMA 335: 2246-2248.
36. Persico AM, Mengual E, Moessner R, Hall SF, Revay RS, Sora I, Arellano J, DeFelipe J, Gimenez-Amaya JM, Conciatori M, Marino R, Baldi A, Cabib S, Pascucci T, Uhl GR, Murphy DL, Lesch KP, Keller F. 2001. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 21: 6862-6873.
37. Sanz EJ, De-las-Cuevas C, Kiuru A, Bate A, Edwards R. 2005. Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis. Lancet 365: 482-487.
38. Simpson KL, Waterhouse BD, Lin RCS. 2003. Differential expression of nitric oxide in serotonergic projection neurons: neurochemical identification of dorsal raphe inputs to rodent trigeminal somatosensory targets. J Comp Neurol 466: 495-512.
39. Vertes RP. 1991. A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J Comp Neurol 313: 643-668.
40. Vertes RP. 1999. Projections of the medial raphe nucleus in the rat. J Comp Neurol 407: 555-582.
41. Wang Q-P, Guan JL, Nakai Y. 1995. Distribution and synaptic relations of NOS neurons in the dorsal raphe nucleus: a comparison to 5-HT neurons. Brain Res Bull 37: 177-187.
42. Waterhouse BD, Mihailoff GS, Baack JC, Woodward DJ. 1986. Topographical distribution of dorsal and median raphe neurons projecting to motor, sensorimotor and visual cortical areas in the rat. J Comp Neurol 249: 460-481.
43. Wisner KL, Zarin DA, Holmboe ES, Appelbaum PS, Gelenberg AJ, Leonard HL. 2000. Risk-benefit decision making for treatment of depression during pregnancy. Am J Psychiatry 157: 1933-1940.
44. Xu Y, Sari Y, Zhou FC. 2004. Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development. Dev Brain Res 150: 151-161.
45. Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. 2006. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Aβ42 accumulation in amyloid model mice. J Biol Chem 281: 36180-36186.
46. Zeskind PS, Stephens LE. 2004. Maternal selective serotonin reuptake inhibitor use during pregnancy and newborn neurobehavior. Pediatrics 113: 368-375.