Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study

Journal of Theoretical Biology

Volumn 269, Issue 1, 2011, Pages 138-149

  Zhu, Xiuwei ^a,b   Zhou, Xiaobo ^b   Lewis, Michael T ^c   Xia, Ling ^a   Wong, Stephen ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b Department of Obstetrics Gynecology   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; Compartment method; Mathematical model; Signaling pathway; Tyrosine kinase inhibitors

Indexed keywords

DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LAPATINIB; PROTEIN TYROSINE KINASE;

BIOLOGICAL METHOD; CANCER; CELL ORGANELLE; COMPUTER SIMULATION; ENZYME; GENE EXPRESSION; INHIBITOR; NUMERICAL MODEL; TUMOR;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RECURRENCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL DIVISION; CELL PROLIFERATION; CELL SUBPOPULATION; ENZYME ACTIVITY; ENZYME INHIBITION; MATHEMATICAL MODEL; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SIMULATION; STEM CELL; TREATMENT RESPONSE; TUMOR VOLUME;

CELL DIVISION; CELL PROLIFERATION; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS; NEOPLASTIC STEM CELLS; PRECANCEROUS CONDITIONS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; STEM CELL NICHE; TUMOR BURDEN;

EID: 78049463670     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2010.10.016     Document Type: Article

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