PEGylated N-methyl-S-methyl dithiocarbazate as a new reagent for the high-yield preparation of nitrido Tc-99m and Re-188 radiopharmaceuticals

Nuclear Medicine and Biology

Volumn 37, Issue 8, 2010, Pages 927-934

  Boschi, Alessandra ^a   Massi, Alessandro ^a   Uccelli, Licia ^a   Pasquali, Micol ^a   Duatti, Adriano ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Dithiocarbazate; Nitrido complexes; Polyethylene glycol; Rhenium 188; Technetium 99m

Indexed keywords

(DIMETHOXYPROPYLPHOSPHINOETHYL)METHOXYETHYLAMINE; AMINE; BIS[(DIMETHOXYPROPYLPHOSPHANYL)ETHYL]ETHOXYETHYLAMINE; CARBAZIC ACID DERIVATIVE; MACROGOL; NITRIDO BIS[(DIMETHOXYPROPYLPHOSPHANYL)ETHYL]ETHOXYETHYLAMINE PEGYLATED N METHYLMETHYLDITHIOCARBAZATE TC 99M; NITRIDO(DIMETHOXYPROPYLPHOSPHINOETHYL)METHOXYETHYLAMINE PEGYLATED N METHYLMETHYLDITHIOCARBAZATE TC 99M; NITROGEN; PEGYLATED N METHYLMETHYLDITHIOCARBAZATE; RADIOPHARMACEUTICAL AGENT; RHENIUM 188; TECHNETIUM 99M; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL BOND; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; HEART MUSCLE; LIVER; LUNG; NONHUMAN; ORGAN DISTRIBUTION; RADIOCHEMISTRY; RAT; REACTION TIME;

ANIMALS; FEMALE; HYDRAZINES; INDICATORS AND REAGENTS; LIGANDS; ORGANOTECHNETIUM COMPOUNDS; POLYETHYLENE GLYCOLS; RADIOISOTOPES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RHENIUM;

EID: 78049460229     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.05.008     Document Type: Article

References (17)

1. {triple bond, short}. Nucl Med Biol 2003, 30:381-387.
2. 99mTc-radiopharmaceuticals containing the TcN multiple bond. Int J Appl Radiat Isot 1992, 43:1329-1333.
3. 2] (noet=N-ethyl-N-ethoxydithiocarbamato). J Chem Soc Chem Commun 1992, 1354-1355.
4. 99mTc nitrido complex for cerebral imaging. Nucl Med Biol 2002, 29(6):665-669.
5. 2+ core towards schiff bases derived from S-methyl dithiocarbazate. Crystal structures of [S-methyl 3-(2-hydroxyphenyl-methylene)dithiocarbazato]nitrido (triphenylphosphine)technetium(V) and bis (S-methyl 3-isopropylidenedithiocarbazato)nitridotecnetium(V). J Chem Soc Dalton Trans 1988, 1743-1749.
6. Baldas J., Bonnyman J., Williams G.A. Studies of technetium complexes. Use of the tetrachloronitridotechnetate(VI) anion for the preparation of nitrido complexes of technetium. Crystal structure of bis(8-quinolinethiolato)nitridotechnetium(V). Inorg Chem 1986, 25:150-155.
7. 2+ (M=Tc or Re) species. J Chem Soc Dalton Trans 1996, 3105-3109.
8. 2+ (PXP=diphosphine ligand). Bioconj Chem 2001, 12(6):1035-1042.
9. Bianchini C., Peruzzini M., Romerosa A., Zanobini F. Ruthenium (II)-mediated reaction of phenylacetylene with primary amines to give ruthenium(II)-isonitrile complexes. Organometallics 1995, 14:3152-3153.
10. Duatti A., Marchi A., Pasqualini R. Formation of the TcN multiple bond from the reaction of ammonium pertechnetate with S-methyl dithiocarbazate and its application to the preparation of technetium-99m radiopharmaceuticals. J Chem Soc Dalton Trans 1990, 3729-3733.
11. Refosco R., Bolzati C., Duatti A., Tisato F., Uccelli L. Mixed ligand Tc- and Re-nitrido complexes for radiolabeling bioactive molecules. Recent Rev Devel Inorg Chem 2000, 2:89-98.
12. Tisato F., Refosco F., Cagnolini A., Bandoli G., Bolzati C., Uccelli L., et al. Reliable synthesis of asymmetrical nitrido Tc(V) and Re(V) heterocomplexes. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 1999, 133-138. SGE Editoriali, Padova, Italy. M. Nicolini, U. Mazzi (Eds.).
13. Refosco F., Tisato F., Cagnolini A., Moresco A., Bandoli G., Bolzati C., et al. Tc and Re nitrido asymmetrical heterocomplexes. A '2+2' approach. Technetium, rhenium and other metals in chemistry and nuclear medicine 1999, 139-144. SGE Editoriali, Padova, Italy. M. Nicolini, U. Mazzi (Eds.).
14. Bolzati C., Boschi A., Duatti A., Prakash S., Uccelli L., Refosco F., et al. Geometrically controlled selective formation of nitrido technetium(V) heterocomplexes with bidentate ligands. J Am Chem Soc 2000, 122:4510-4511.
15. Harris J.M., Chess R.B. Effect of PEGylation on pharmaceuticals. Nat Rev Drug Discoveries 2003, 2:214-221.
16. Pasut G., Guiotto A., Veronese F.M. Protein, peptide and non-peptide drug PEGylation for therapeutical application: a review. Expert Opin Ther Pat 2004, 14:859-894.
17. 99mTc-nitride heterocomplexes showing high heart uptake and improved imaging properties. Journal of Nuclear Medicine 2003, 44(5):806-814.