Pharmacological effect of deoxypodophyllotoxin: A medicinal agent of plant origin, on mammalian neurons

NeuroToxicology

Volumn 31, Issue 6, 2010, Pages 680-686

  Xu, Peng ^a   Sun, Qin ^a   Wang, Xijie ^a   Zhang, Shougang ^a   An, Shanshan ^a   Cheng, Jie ^a   Gao, Rong ^a   Xiao, Hang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Dorsal root ganglion (DRG) neurons; Sodium channels; Tetrodotoxin; Whole cell patch clamp

Indexed keywords

CALCIUM ION; DEOXYPODOPHYLLOTOXIN; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ELECTROPHYSIOLOGY; NERVE CELL; NERVE CELL EXCITABILITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SODIUM CURRENT; SPINAL GANGLION; VOLTAGE CLAMP;

ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; MEMBRANE POTENTIALS; NEURONS; PLANT EXTRACTS; PLANTS, MEDICINAL; PODOPHYLLOTOXIN; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; MAMMALIA; RATTUS;

EID: 78049458131     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2010.08.002     Document Type: Article

References (32)

1. Akopian A.N., Sivilotti L., Wood J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 1996, 379(6562):257-262.
2. Amaya F., Wang H., Costigan M., Allchorne A.J., Hatcher J.P., Egerton J., et al. The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci 2006, 26(50):12852-12860.
3. + channels confer invasive properties on human prostate cancer cells. Pflugers Arch 2004, 447(6):908-914.
4. Benson J.A. Natural and synthetic toxins at insect receptors and ion channels: the search for insecticide leads and target sites. Molecular basis of drug and pesticide action 1992, 57-70. Elsevier Applied Science, London, New York. I.R. Duce (Ed.).
5. Carafoli E. Calcium-a universal carrier of biological signals delivered on 3 July 2003 at the special FEBS meeting in Brussels. FEBS J 2005, 272(5):1073-1089.
6. 2+ channels and snare proteins in neurotransmitter release. Ann N Y Acad Sci 1999, 868:144-159.
7. 2+ signaling in renal tubular cells. Eur J Pharmacol 2002, 443(1-3):31-38.
8. Cummins T.R., Sheets P.L., Waxman S.G. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain 2007, 131(3):243-257.
9. Dong X.W., Goregoaker S., Engler H., Zhou X., Mark L., Crona J., et al. Small interfering RNA-mediated selective knockdown of Na(V)1.8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats. Neuroscience 2007, 146(2):812-821.
10. 2+ signaling networks in regulating gene expression by action potentials. Cell Calcium 2005, 37(5):433-442.
11. Gao R., Di X.D., Liu Y.Q., Yu X.Y., Liu X.J., Xiao H. Effects of four podophyllotoxin analogues on spontaneous action potentials of the central nerve cord of Periplaneta americana. Acta Entomol Sin 2009, 52(2):168-174.
12. Gao R., Gao C., Tian X., Yu X., Di X., Xiao H. Insecticidal activity of deoxypodophyllotoxin, isolated from Junipeersus sabina L., and related lignans against larvae of Pieris rapae L. Pest Manage Sci 2004, 60(11):1131-1136.
13. Goldberg Y.P., MacFarlane J., MacDonald M.L., Thompson J., Dube M.P., Mattice M. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet 2007, 71(4):311-319.
14. Gordaliza M., Castro M.A., del Corral J.M., Feliciano A.S. Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des 2000, 6(18):1811-1839.
15. Gordon D. Sodium channels as targets for neurotoxins: mode of action and interaction of neurotoxins with receptor sites on sodium channels. Toxins Signal Transduct 1997, 119-149.
16. Inamori Y., Kubo M., Tsujibo H., Oki S., Kodana Y., Ogawa K. Mechanisms of insecticidal action of deoxypodophyllotoxin (Anthricin). III. The mode of delayed insecticidal action of deoxypodophyllotoxin. Chem Pharm Bull 1986, 34:2247-2250.
17. Lee S.H., Son M.J., Ju H.K., Lin C.X., Moon T.C., Choi H.G., et al. Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells. Biol Pharm Bull 2004, 27(6):786-788.
18. Lu C., Fu W., Zhao D., Mattson M.P. The DNA damaging agent etoposide activates a cell survival pathway involving alpha-amino-3-hydroxy-5-m-ethylisoxazole-4-propionate receptors and mitogen-activatd protein kinases in hippocampal neurons. J Neurosci Res 2002, 70(5):671-679.
19. Miyazawa M., Fukuyama M., Yoshio K., Kato T., Ishikawa Y. Biologically active components against Drosophila melanogaster from Podophyllum hexandrum. J Agric Food Chem 1999, 47(12):5108-5110.
20. Muto N., Tomokuni T., Haramoto M., Tatemoto H., Nakanishi T., Inatomi Y., et al. Isolation of apoptosis- and differentiation-inducing substances toward human promyelocytic leukemia HL-60 cells from leaves of Juniperus taxifolia. Biosci Biotechnol Biochem 2008, 72(2):477-484.
21. Narahashi T. Neuroreceptors and ion channels as the basis for drug action: past, present, and future. J Pharmacol Exp Ther 2000, 294(1):1-26.
22. + channel expression in vitro. J Membr Biol 2005, 204(2):67-75.
23. Salgado V.L. Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides. Mol Pharmacol 1992, 41(1):120-126.
24. Sattelle D.B., Yamamoto D. Molecular targets of pyrethroid insecticides. Adv Insect Physiol 1988, 20:147-213.
25. Song J.H., Huang C.S., Nagata K., Yeh J.Z., Narahashi T. Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther 1997, 282(2):707-714.
26. + channels and after hyperpolarizations. Toxicon 2004, 43(8):933-949.
27. Stridh H., Gigliotti D., Orrenius S., Cotgreave I. The role of calcium in pre-and postmitochondrial events in tributyltin-induced T-cell apoptosis. Biochem Biophys Res Commun 1999, 266(2):460-465.
28. Suh S.J., Kim J.R., Jin U.H., Choi H.S., Chang Y.C., Lee Y.C., et al. Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. Inhibits migration and MMP-9 via MAPK pathways in TNF-α-induced HASMC. Vascul Pharmacol 2009, 51(1):13-20.
29. West A.E., Chen W.G., Dalva M.B., Dolmetsch R.E., Kornhauser J.M., Shaywitz A.J., et al. Calcium regulation of neuronal gene expression. Proc Natl Acad Sci USA 2001, 98(20):11024-11031.
30. Zhang S.G., Hou H.M., Gao R., Liu Y.Q., He B., Di X.D., et al. Toxicity of deoxypodophyllotoxin to Periplaneta americana and its effects on AchE and ATPase. Acta Entomol Sin 2007, 50(3):248-252.
31. Zhang S.G., Liu Y.Q., Gao R., He B., Zhao H.Y., Di X.D., et al. Effects of deoxypodophyllotoxin on the activity of AchE and ATPase in the head of 3rd instar larvae of Pieris rapae L. Acta Univ Med Nanjing 2007, 27(6):542-545.
32. Zlotkin E. The insect voltage-gated sodium channels as target of insecticides. Annu Rev Entomol 1999, 44:429-455.