Diagnosing pediatric appendicitis: Usefulness of laboratory markers

American Journal of Emergency Medicine

Volumn 28, Issue 9, 2010, Pages 1009-1015

  Kwan, Karen Y ^a   Nager, Alan L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; LACTIC ACID; PROCALCITONIN;

ABDOMINAL PAIN; ACUTE APPENDICITIS; ADOLESCENT; ADULT; ARTICLE; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; EMERGENCY WARD; EPIGASTRIC PAIN; FEMALE; HUMAN; LACTATE BLOOD LEVEL; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NEUTROPHIL COUNT; OBSERVATIONAL STUDY; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; SCHOOL CHILD;

ABDOMINAL PAIN; ADOLESCENT; APPENDICITIS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CHILD; CHILD, PRESCHOOL; CONFIDENCE INTERVALS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INFANT; LACTIC ACID; LEUKOCYTE COUNT; LOGISTIC MODELS; MALE; ODDS RATIO; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; RISK FACTORS; ROC CURVE;

EID: 78049457045     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2009.06.004     Document Type: Article

References (43)

1. Schnaufer L., and Mahboubi S. G.R. Fleisher, S. Ludwig, Abdominal emergencies from textbook of pediatric emergency medicine 2000 Lippincott Williams & Wilkins pub Philadelphia 1513 1518 Chapter 118
2. Gronroos J.M. Leucocyte count and C-reactive protein in the diagnosis of acute appendicitis BR J Surg 86 1999 501 504
3. Rothrock S.G. Acute appendicitis in children Emerg Dep Diagn Manage 36 2000 39 51
4. Hoffman J. Aids in the diagnosis of acute appendicitis Br J Surg. 76 1989 774 779
5. Rothrock S.G. Clinical features of misdiagnosed appendicitis in children Ann Emerg Med 20 1991 45 50
6. Wesson D. Appendicitis in children. Uptodate.com 2004.
7. Andersson R.E., Hugander A.P., and Ghazi S.H. Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis World J Surg 23 1999 133 140
8. Rodriguez-Sanjuan J.C. C-reactive protein and leukocyte count in the diagnosis of acute appendicitis in children Dis Colon Rectum 42 10 1999 1325 1329
9. Brown L.L. Diagnostic utility of c-reactive protein in children with suspected appendicitis PAS/SPR Platform Session. May 2 2004
10. Dueholm S., Bagi P., and Bud M. Laboratory aid in the diagnosis of acute appendicitis. A blinded, prospective trial concerning diagnostic value of leukocyte count, neutrophil differential count, and C-reactive protein Dis Colon Rectum 32 1989 855 859
11. Drury D.R., and Wick A.N. Chemistry and metabolism of l(+) and d(-) lactic acids Ann NY Acad Sci 119 1965 1061 1069
12. Marcod M.A. Determination of d(-)-lactate concentration for rapid diagnosis of bacterial infection of body fluids Eur J Clin Microbiol Infect Dis 10 1991 966 969
13. Murray M. Serum d-lactate levels as an aid to diagnosis acute intestinal ischemia Am J Surg 167 1994 5575 5578
14. Gaglayan F. Plasma d-lactate levels in diagnosis of appendicitis J Invest Surg 16 4 2003 233 237
15. Gendrel D., Raymond J., and Coste J. Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-α for differentiation of bacterial vs viral infections Pediatr Infect Dis J 18 10 1999 875 881
16. Hatherill M., Tibby S.M., Sykes K., Turner C., and Murdoch I.A. Diagnostic markers of infection: comparison of procalcitonin with C-reactive protein and leucocyte count Arch dis Child. 81 5 1999 417 421
17. Carrol E.D. Procalcitonin as a marker of sepsis Inter J Antimicrob Agents 20 2002 1 9
18. Gendrel D. Procalcitonin as a marker of bacterial infection Pediatr Infect Dis J. 19 2000 679 688
19. Elangovan S. Clinical and laboratory findings in acute appendicitis in the elderly J Am Board Fam Pract 9 1996 75 78
20. Calder J.D., and Gajraj H. Recent advances in the diagnosis and treatment of acute appendicitis Br J Hosp Med 54 1995 129 133
21. Lau W.Y., Ho Y.C., and Chu K.W. Leucocyte count and neutrophil percentage in appendicectomy for suspected appendicitis Aust NZ J Surg 59 1989 395 398
22. Doraiswamy N.V. Leucocyte counts in the diagnosis and prognosis of acute appendicitis in children Br J Surg 66 1979 782 784
23. Miskowiak J., and Burcharth F. The white cell count in acute appendicitis. A prospective blind study Dan Med Bull 29 1982 210 211
24. Peltola H., Ahlqvist J., and Rapola J. C-reactive protein compared with white blood cell count and erythrocyte sedimentation rate in the diagnosis of acute appendicitis in children Acta Chir Scand 152 1986 55 58
25. SAS Institute Inc SAS/STAT user's guide, Version 8 1999 SAS Institute Inc Cary (NC) 3884pp
26. Reynolds S.L. Missed appendicitis in a pediatric emergency department Pediatr Emerg Care 9 1993 1 3
27. Kosloske A. The diagnosis of appendicitis in children: outcomes of a strategy based on pediatric surgical evaluation Pediatrics 113 2004 29 34
28. Amland P.F., Skaane P., and Ronningen H. Ultrasonography and parameters of inflammation in acute appendicitis. A comparison with clinical findings Acta Chir Scand 155 1989 185 189
29. Pena B. Effect of an imaging protocol on clinical outcomes among pediatric patients with appendicitis Pediatrics 110 6 2002 1088 1093
30. Brenner D.J., Elliston C.D., Hall E.J., and Berdon W.E. Estimated risks of radiation-induced fatal cancer from pediatric CT AJR Am J Roentgenol 176 2001 289 296
31. Paterson A., Frush D.P., and Donnelly L.F. Helical CT of the body: are settings adjusted for pediatric patients? AJR Am J Roentgenol 176 2001 297 301
32. Hall E.J. Lessons we have learned from our children: cancer risks from diagnostic radiology Pediatr Radiol 32 2002 700 706
33. Eriksson S., Granstrom L., and Carlstrom A. The diagnostic value of repetitive preoperative analyses of C-reactive protein and total leucocyte count in patients with suspected acute appendicitis Scand J Gastroenterol 29 1994 1145 1149
34. Doraiswamy N.W. Progress of acute appendicitis: a study in children Br J Surg. 65 1978 877 879
35. Hallan S., Asberg A., and Edna T.H. Additional value of biochemical tests in suspected acute appendicitis Eur J Surg 163 1997 533 538
36. Yang H.R., Wang Y.C., and al e.t. Laboratory tests in patients with acute appendicitis ANZ J Surg 76 2006 71 74
37. Rodríguez-Sanjuán J.C., Martín-Parra J.I., Seco I., García-Castrillo L., and Naranjo A. C-reactive protein and leukocyte count in the diagnosis of acute appendicitis in children Dis Colon Rectum. 42 10 1999 Oct 1325 1329
38. Wang L.T., Prentiss K.A., Simon J.Z., Doody D.P., and Ryan D.P. The use of white blood cell count and left shift in the diagnosis of appendicitis in children Pediatr Emerg Care. 23 2 2007 Feb 69 76
39. Gronroos J.M. Is there a role for leukocyte and CRP measurements in the diagnosis of acute appendicitis in the elderly? Maturitas 31 1999 255 258
40. Beltran M.A., Almonacid J., and Cumsille M.A. Predictive value of white blood cell count and C-reactive protein in children with appendicitis J of Pediatr Surg 42 7 2007 1208 1214
41. Okamoto T., Sano K., and Ogasahara K. Receiver-operating characteristic analysis of leukocyte counts and serum C-reactive protein levels in children with advanced appendicitis Surg Today. 36 6 2006 515 518
42. Graffeo C.S., and Counselman F.L. Appendicitis Emerg Med Clin North Am 14 1996 653 671
43. Kessler N., Cyeval C., and Taourel P. Appendicitis: evaluation of sensitivity, specificity, and predictive values of US, Doppler US and laboratory findings Radiology 230 2004 472