Interleukin-1 receptor antagonist in animal models of stroke: A fair summing up?

Journal of Stroke and Cerebrovascular Diseases

Volumn 19, Issue 6, 2010, Pages 512-513

  Parry Jones, Adrian ^a   Boutin, Hervé ^a   Denes, Adam ^a   McColl, Barry ^a   Hopkins, Steve ^a   Allan, Stuart ^a   Tyrrell, Pippa ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TISSUE PLASMINOGEN ACTIVATOR;

CLINICAL RESEARCH; DRUG EFFICACY; EXPERIMENTAL MODEL; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; STROKE;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; EVIDENCE-BASED MEDICINE; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; META-ANALYSIS AS TOPIC; REPRODUCIBILITY OF RESULTS; REVIEW LITERATURE AS TOPIC; STROKE;

EID: 78049456330     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2010.01.005     Document Type: Letter

References (9)

1. V. Banwell, E.S. Sena, and M.R. Macleod Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke J Stroke Cerebrovasc Dis 18 2009 269 276
2. P. Perel, I. Roberts, and E. Sena Comparison of treatment effects between animal experiments and clinical trials: Systematic review BMJ 334 2007 197
3. M.R. Macleod, H.B. van der Worp, and E.S. Sena Evidence for the efficacy of NXY-059 in experimental focal cerebral ischemia is confounded by study quality Stroke 39 2008 2824 2829
4. M.R. Macleod, T. O'Collins, and L.L. Horky Systematic review and meta-analysis of the efficacy of FK506 in experimental stroke J Cereb Blood Flow Metab 25 2005 713 721
5. S.R. Clark, C.J. McMahon, and I. Gueorguieva Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations J Cereb Blood Flow Metab 28 2008 387 394
6. M.R. Macleod, T. O'Collins, and D.W. Howells Pooling of animal experimental data reveals influence of study design and publication bias Stroke 35 2004 1203 1208
7. J.J. Legos, S.C. Lenhard, and R.E. Haimbach SB 234551 selective ETA receptor antagonism: Perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection Exp Neurol 212 2008 53 62
8. P.A. Barber, S.M. Davis, and D.G. Darby Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra Neurology 52 1999 1125 1132
9. Clark S, Rothwell N. Peripheral administration of interleukin-1 receptor antagonist (IL-1RA) reduces ischemic brain damage in the rat. In: The Brain 05 Meeting of the International Society for Cerebral Blood Flow and Metabolism. Amsterdam: 2005