α-glucosidase inhibition and the in vivo hypoglycemic effect of butyl-isobutyl-phthalate derived from the Laminaria japonica rhizoid

Phytotherapy Research

Volumn 24, Issue 11, 2010, Pages 1588-1591

  Bu, Tong ^a   Liu, Ming ^a   Zheng, Lanhong ^a   Guo, Yuewei ^b   Lin, Xiukun ^a  

^a INSTITUTE OF OCEANOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

glucosidase; Butyl isobutyl phthalate; Hypoglycemic effect; Laminaria japonica; Rhizoid

Indexed keywords

ACARBOSE; ACETIC ACID ETHYL ESTER; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; BUTYLISOBUTYLPHTHALIC ACID; DNA TOPOISOMERASE; LAMINARIA JAPONICA EXTRACT; PHTHALIC ACID DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG EFFECT; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; IC 50; IN VIVO STUDY; LAMINARIA; LAMINARIA JAPONICA; MALE; MOUSE; NONHUMAN; STREPTOMYCES ALBIDOFLAVUS; STREPTOZOCIN DIABETES; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIBUTYL PHTHALATE; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; LAMINARIA; MALE; MICE; PLANT EXTRACTS;

LAMINARIA JAPONICA; MUS;

EID: 78049440471     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3139     Document Type: Article

References (14)

1. Chiu KW, Fung AYL. 1997. The cardiovascular effects of green beans (Phaseolus aureus), common rue (Ruta graveolens), and kelp (Laminaria japonica) in rats. Gen Pharmacol 29: 859-862.
2. El-Naggar MYM. 1997. Dibutyl phthalate and the antitumour agent F5A1, two metabolites produced by Streptomyces nasri submutant H35. Biomed Lett 55: 125-131.
3. Han J KS, Choue R, Kim H et al. 2002. Free radical scavenging effect of Diospyros kaki, Laminaria japonica and Undaria pinnatifida. Fitoterapia 73: 710-712.
4. Jin DQ, Li G, JS Kim et al. 2004. Preventive effects of Laminaria japonica aqueous extract on the oxidative stress and xanthine oxidase activity in streptozotocin-induced diabetic rat liver. Biol Pharm Bull 27: 1037-1040.
5. Lee DS. 2000. Dibutyl phthalate, an alpha-glucosidase inhibitor from Streptomyces melanosporofaciens. J Biosci Bioeng 89: 271-273.
6. Lee DS, Hong SD. 1996. Inhibition mode of DNA topoisomerase by dibutyl phthalate. J Microbiol Biotechn 6: 366-367.
7. Lee KBB, Bae M, Jang M et al. 1999. Effect of sea tangle and metformin on lipid peroxide and antioxidants levels in diabetic rats. Korean J Nutr 32: 230-238.
8. Makhija SN, Vavia PR. 2003. Controlled porosity osmotic pump-based controlled release systems of pseudoephedrine I. Cellulose acetate as a semipermeable membrane. J Control Release 89: 5-18.
9. Marchetti L, SabbiEti MG, Menghi M et al. 2002. Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts. Histol Histopathol 17: 1061-1066.
10. O'Brien ML, Cunningham ML, Spear BT et al. 2001. Effects of peroxisome proliferators on glutathione and glutathione-related enzymes in rats and hamsters. Toxicol Appl Pharm 171: 27-37.
11. Okai YH-OK, Nakamura S. 1993. Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by the umu gene expression system in Salmonella typhimurium (TA1535/pSK1002). Mutat Res 303: 63-70.
12. Roy RN, Laskar S, Sen SK. 2006. Dibutyl phthalate, the bioactive compound produced by Streptomyces albidoflavus 321.2. Microbiol Res 161: 121-126.
13. Scott LJ, Spencer CM. 2000. Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus. Drugs 59: 521-549.
14. Tsujii E, Muroi M, Shiragami N et al. 1996. Nectrisine is a potent inhibitor of α-glucosidases, demonstrating activities similarly at enzyme and cellular levels. Biochem Biophys Res Commun 220: 459-466.