Neurocognitive function in sickle cell disease: Have we been missing something?

Expert Review of Hematology

Volumn 3, Issue 5, 2010, Pages 519-521

  Armstrong, F Daniel ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

adults; anemia; children; neurocognitive function; sickle cell anemia; stroke

Indexed keywords

HYDROXYUREA; NITRIC OXIDE; OXYGEN;

ACADEMIC ACHIEVEMENT; BLOOD FLOW VELOCITY; BLOOD TRANSFUSION; BRAIN BLOOD FLOW; BRAIN INFARCTION; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; DOPPLER ECHOGRAPHY; EDITORIAL; HEALTH CENTER; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOXIA; INTELLIGENCE QUOTIENT; JOB PERFORMANCE; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN DIFFUSION; PATIENT COMPLIANCE; PERFUSION; PRIORITY JOURNAL; READING; SICKLE CELL ANEMIA; STROKE; TERATOGENICITY;

ANEMIA, SICKLE CELL; COGNITIVE THERAPY; HUMANS; HYDROXYUREA; NEUROPSYCHOLOGICAL TESTS;

EID: 78049428294     PISSN: 17474086     EISSN: None     Source Type: Journal    
DOI: 10.1586/ehm.10.59     Document Type: Editorial

References (13)

1. Chordokoff J, Whitten CF. Intellectual status of children with sickle cell anemia. J. Pediatr. 63, 29-35 (1963).
2. Jensen, A. How much can we boost IQ and school achievement? Harv. Educ. Rev. 39, 1-123 (1969).
3. Armstrong FD, Thompson RJ Jr, Wang W et al. Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics 97, 864-870 (1996).
4. Wang W, Enos L, Gallagher D et al. Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. J. Pediatr. 139, 391-397 (2001).
5. Armstrong FD, Pavlakis S, Goldman ML, Thompson W, Cuadra A, Sulc W. Neurocognitive outcomes in sickle cell disease. In: Cognitive and Behavioral Abnormalities of Pediatric Diseases. Nass R, Frank Y (Eds). Oxford University Press, NY, USA 285-292 (2010).
6. Adams RJ, McKie VC, Brambilla D et al. Stroke prevention trial in sickle cell anemia. Control Clin. Trials 19, 110-129 (1998).
7. Adams RJ, Brambilla D. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N. Engl. J. Med. 353, 2769-2778 (2005).
8. Kral MC, Brown RT, Nietert PJ, Abboud MR, Jackson SM, Hynd GW. Transcranial Doppler ultrasonography and neurocognitive functioning in children with sickle cell disease. Pediatrics 112, 324-331 (2003).
9. Thompson BW, Miller ST, Rogers ZR et al. The pediatric hydroxyurea Phase III clinical trial (BABY HUG): challenges of study design. Pediatr. Blood Cancer 54, 250-255 (2010).
10. Wang WC, Helms RW, Lynn HS et al. Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study. J. Pediatr. 140, 225-229 (2002).
11. Steinberg MH, McCarthy WF, Castro O et al. The risks and benefts of long-term use of hydroxyurea in sickle cell anemia: a 17.5 year follow-up. Am. J. Hematol. 85, 403-408 (2010).
12. Vichinsky EP, Neumayr LD, Gold JI et al. Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA 303, 1823-1831 (2010).
13. Ballas SK. Neurocognitive complications of sickle cell anemia in adults. JAMA 303, 1862-1863 (2010).