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Volumn 38, Issue 18, 2010, Pages 6054-6064

A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DNA; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ISOLEUCINE; DNA (CYTOSINE 5) METHYLTRANSFERASE;

EID: 78049423376     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq456     Document Type: Article
Times cited : (10)

References (59)
  • 1
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev., 16, 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 2
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones,P.A. and Baylin,S.B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 3
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson,K.D. (2005) DNA methylation and human disease. Nat. Rev. Genet., 6, 597-610.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 4
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll,M.G. and Bestor,T.H. (2005) Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem., 74, 481-514.
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 5
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano,M., Bell,D.W., Haber,D.A. and Li,E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 7
    • 4143088126 scopus 로고    scopus 로고
    • Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro
    • Robertson,A.K., Geiman,T.M., Sankpal,U.T., Hager,G.L. and Robertson,K.D. (2004) Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. Biochem. Biophys. Res. Commun., 322, 110-118.
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 110-118
    • Robertson, A.K.1    Geiman, T.M.2    Sankpal, U.T.3    Hager, G.L.4    Robertson, K.D.5
  • 8
    • 33646353209 scopus 로고    scopus 로고
    • Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA
    • Takeshima,H., Suetake,I., Shimahara,H., Ura,K., Tate,S. and Tajima,S. (2006) Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA. J. Biochem., 139, 503-515.
    • (2006) J. Biochem. , vol.139 , pp. 503-515
    • Takeshima, H.1    Suetake, I.2    Shimahara, H.3    Ura, K.4    Tate, S.5    Tajima, S.6
  • 9
    • 53149096921 scopus 로고    scopus 로고
    • Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1
    • Takeshima,H., Suetake,I. and Tajima,S. (2008) Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1. J. Mol. Biol., 383, 810-821.
    • (2008) J. Mol. Biol. , vol.383 , pp. 810-821
    • Takeshima, H.1    Suetake, I.2    Tajima, S.3
  • 10
    • 3042584653 scopus 로고    scopus 로고
    • Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    • Kaneda,M., Okano,M., Hata,K., Sado,T., Tsujimoto,N., Li,E. and Sasaki,H. (2004) Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature, 429, 900-903.
    • (2004) Nature , vol.429 , pp. 900-903
    • Kaneda, M.1    Okano, M.2    Hata, K.3    Sado, T.4    Tsujimoto, N.5    Li, E.6    Sasaki, H.7
  • 11
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    • Chen,T., Ueda,Y., Dodge,J.E., Wang,Z. and Li,E. (2003) Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell Biol., 23, 5594-5605.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 12
    • 33744552284 scopus 로고    scopus 로고
    • CpG sites preferentially methylated by Dnmt3a in vivo
    • Oka,M., Rodic,N., Graddy,J., Chang,L.J. and Terada,N. (2006) CpG sites preferentially methylated by Dnmt3a in vivo. J. Biol. Chem., 281, 9901-9908.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9901-9908
    • Oka, M.1    Rodic, N.2    Graddy, J.3    Chang, L.J.4    Terada, N.5
  • 13
    • 24044481947 scopus 로고    scopus 로고
    • Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization
    • Dodge,J.E., Okano,M., Dick,F., Tsujimoto,N., Chen,T., Wang,S., Ueda,Y., Dyson,N. and Li,E. (2005) Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J. Biol. Chem., 280, 17986-17991.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17986-17991
    • Dodge, J.E.1    Okano, M.2    Dick, F.3    Tsujimoto, N.4    Chen, T.5    Wang, S.6    Ueda, Y.7    Dyson, N.8    Li, E.9
  • 14
    • 33645735015 scopus 로고    scopus 로고
    • Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome
    • Ueda,Y., Okano,M., Williams,C., Chen,T., Georgopoulos,K. and Li,E. (2006) Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development, 133, 1183-1192.
    • (2006) Development , vol.133 , pp. 1183-1192
    • Ueda, Y.1    Okano, M.2    Williams, C.3    Chen, T.4    Georgopoulos, K.5    Li, E.6
  • 15
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • International-Human-Genome-Sequencing-Consortium
    • International-Human-Genome-Sequencing-Consortium. (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860-921.
    • (2001) Nature , vol.409 , pp. 860-921
  • 16
    • 33947127751 scopus 로고    scopus 로고
    • Origin of avian genome size and structure in non-avian dinosaurs
    • Organ,C.L., Shedlock,A.M., Meade,A., Pagel,M. and Edwards,S.V. (2007) Origin of avian genome size and structure in non-avian dinosaurs. Nature, 446, 180-184.
    • (2007) Nature , vol.446 , pp. 180-184
    • Organ, C.L.1    Shedlock, A.M.2    Meade, A.3    Pagel, M.4    Edwards, S.V.5
  • 17
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder,J.A., Walsh,C.P. and Bestor,T.H. (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet., 13, 335-340.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 20
    • 29644440388 scopus 로고    scopus 로고
    • Establishment and maintenance of DNA methylation patterns in mammals
    • Chen,T. and Li,E. (2006) Establishment and maintenance of DNA methylation patterns in mammals. Curr. Top. Microbiol. Immunol., 301, 179-201.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.301 , pp. 179-201
    • Chen, T.1    Li, E.2
  • 21
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • Okano,M., Xie,S. and Li,E. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet., 19, 219-220.
    • (1998) Nat. Genet. , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 22
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • Hermann,A., Gowher,H. and Jeltsch,A. (2004) Biochemistry and biology of mammalian DNA methyltransferases. Cell Mol. Life Sci., 61, 2571-2587.
    • (2004) Cell Mol. Life Sci. , vol.61 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 24
    • 0032893932 scopus 로고    scopus 로고
    • Preservation of duplicate genes by complementary, degenerative mutations
    • Force,A., Lynch,M., Pickett,F.B., Amores,A., Yan,Y.L. and Postlethwait,J. (1999) Preservation of duplicate genes by complementary, degenerative mutations. Genetics, 151, 1531-1545.
    • (1999) Genetics , vol.151 , pp. 1531-1545
    • Force, A.1    Lynch, M.2    Pickett, F.B.3    Amores, A.4    Yan, Y.L.5    Postlethwait, J.6
  • 25
    • 0036845822 scopus 로고    scopus 로고
    • Splitting pairs: the diverging fates of duplicated genes
    • Prince,V.E. and Pickett,F.B. (2002) Splitting pairs: the diverging fates of duplicated genes. Nat. Rev. Genet., 3, 827-837.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 827-837
    • Prince, V.E.1    Pickett, F.B.2
  • 26
    • 10944230777 scopus 로고    scopus 로고
    • Duplication and divergence: the evolution of new genes and old ideas
    • Taylor,J.S. and Raes,J. (2004) Duplication and divergence: the evolution of new genes and old ideas. Annu. Rev. Genet., 38, 615-643.
    • (2004) Annu. Rev. Genet. , vol.38 , pp. 615-643
    • Taylor, J.S.1    Raes, J.2
  • 27
    • 0034623005 scopus 로고    scopus 로고
    • T-Coffee: a novel method for fast and accurate multiple sequence alignment
    • Notredame,C., Higgins,D.G. and Heringa,J. (2000) T-Coffee: a novel method for fast and accurate multiple sequence alignment. J. Mol. Biol., 302, 205-217.
    • (2000) J. Mol. Biol. , vol.302 , pp. 205-217
    • Notredame, C.1    Higgins, D.G.2    Heringa, J.3
  • 28
    • 45949109669 scopus 로고    scopus 로고
    • MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences
    • Kumar,S., Nei,M., Dudley,J. and Tamura,K. (2008) MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform., 9, 299-306.
    • (2008) Brief Bioinform , vol.9 , pp. 299-306
    • Kumar, S.1    Nei, M.2    Dudley, J.3    Tamura, K.4
  • 29
    • 0022507362 scopus 로고
    • Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions
    • Nei,M. and Gojobori,T. (1986) Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol. Biol. Evol., 3, 418-426.
    • (1986) Mol. Biol. Evol. , vol.3 , pp. 418-426
    • Nei, M.1    Gojobori, T.2
  • 30
    • 0027453388 scopus 로고
    • Simple methods for testing the molecular evolutionary clock hypothesis
    • Tajima, F. (1993) Simple methods for testing the molecular evolutionary clock hypothesis. Genetics, 135, 599-607.
    • (1993) Genetics , vol.135 , pp. 599-607
    • Tajima, F.1
  • 31
    • 0036311336 scopus 로고    scopus 로고
    • Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography
    • Ramsahoye, B.H. (2002) Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography. Methods, 27, 156-161.
    • (2002) Methods , vol.27 , pp. 156-161
    • Ramsahoye, B.H.1
  • 32
    • 34548603504 scopus 로고    scopus 로고
    • Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
    • Jia,D., Jurkowska,R.Z., Zhang,X., Jeltsch,A. and Cheng,X. (2007) Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 248-251.
    • (2007) Nature , vol.449 , pp. 248-251
    • Jia, D.1    Jurkowska, R.Z.2    Zhang, X.3    Jeltsch, A.4    Cheng, X.5
  • 33
    • 0030471926 scopus 로고    scopus 로고
    • A modified and improved method for bisulphite based cytosine methylation analysis
    • Olek,A., Oswald,J. and Walter,J. (1996) A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res., 24, 5064-5066.
    • (1996) Nucleic Acids Res , vol.24 , pp. 5064-5066
    • Olek, A.1    Oswald, J.2    Walter, J.3
  • 34
    • 1842364873 scopus 로고    scopus 로고
    • Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells
    • Tada,M., Tada,T., Lefebvre,L., Barton,S.C. and Surani,M.A. (1997) Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J., 16, 6510-6520.
    • (1997) EMBO J , vol.16 , pp. 6510-6520
    • Tada, M.1    Tada, T.2    Lefebvre, L.3    Barton, S.C.4    Surani, M.A.5
  • 35
    • 0035890090 scopus 로고    scopus 로고
    • Lsh, a member of the SNF2 family, is required for genome-wide methylation
    • Dennis,K., Fan,T., Geiman,T., Yan,Q. and Muegge,K. (2001) Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev., 15, 2940-2944.
    • (2001) Genes Dev , vol.15 , pp. 2940-2944
    • Dennis, K.1    Fan, T.2    Geiman, T.3    Yan, Q.4    Muegge, K.5
  • 36
    • 35348999494 scopus 로고    scopus 로고
    • Expression of murine DNA methyltransferases Dnmt1 and Dnmt3a in the yeast Saccharomyces cerevisiae
    • Bulkowska,U., Ishikawa,T., Kurlandzka,A., Trzcinska-Danielewicz,J., Derlacz,R. and Fronk,J. (2007) Expression of murine DNA methyltransferases Dnmt1 and Dnmt3a in the yeast Saccharomyces cerevisiae. Yeast, 24, 871-882.
    • (2007) Yeast , vol.24 , pp. 871-882
    • Bulkowska, U.1    Ishikawa, T.2    Kurlandzka, A.3    Trzcinska-Danielewicz, J.4    Derlacz, R.5    Fronk, J.6
  • 37
    • 0021132637 scopus 로고
    • 5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA
    • Proffitt,J.H., Davie,J.R., Swinton,D. and Hattman,S. (1984) 5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA. Mol. Cell Biol., 4, 985-988.
    • (1984) Mol. Cell Biol. , vol.4 , pp. 985-988
    • Proffitt, J.H.1    Davie, J.R.2    Swinton, D.3    Hattman, S.4
  • 38
    • 0033135285 scopus 로고    scopus 로고
    • Eukaryotic DNA methylation as an evolutionary device
    • Colot,V. and Rossignol,J.L. (1999) Eukaryotic DNA methylation as an evolutionary device. Bioessays, 21, 402-411.
    • (1999) Bioessays , vol.21 , pp. 402-411
    • Colot, V.1    Rossignol, J.L.2
  • 39
    • 33645452014 scopus 로고    scopus 로고
    • Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting
    • Yokomine,T., Hata,K., Tsudzuki,M. and Sasaki,H. (2006) Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting. Cytogenet. Genome Res., 113, 75-80.
    • (2006) Cytogenet. Genome Res. , vol.113 , pp. 75-80
    • Yokomine, T.1    Hata, K.2    Tsudzuki, M.3    Sasaki, H.4
  • 40
    • 0036544871 scopus 로고    scopus 로고
    • Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey
    • Zhang,J., Zhang,Y.P. and Rosenberg,H.F. (2002) Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkey. Nat. Genet., 30, 411-415.
    • (2002) Nat. Genet. , vol.30 , pp. 411-415
    • Zhang, J.1    Zhang, Y.P.2    Rosenberg, H.F.3
  • 42
    • 33748784344 scopus 로고    scopus 로고
    • A simple statistical method for estimating type-II (cluster-specific) functional divergence of protein sequences
    • Gu,X. (2006) A simple statistical method for estimating type-II (cluster-specific) functional divergence of protein sequences. Mol. Biol. Evol., 23, 1937-1945.
    • (2006) Mol. Biol. Evol. , vol.23 , pp. 1937-1945
    • Gu, X.1
  • 44
    • 10644283823 scopus 로고    scopus 로고
    • Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
    • International-Chicken-Genome-Sequencing-Consortium
    • International-Chicken-Genome-Sequencing-Consortium. (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature, 432, 695-716.
    • (2004) Nature , vol.432 , pp. 695-716
  • 45
    • 0031027468 scopus 로고    scopus 로고
    • Methylation of genomes and genes at the invertebrate-vertebrate boundary
    • Tweedie,S., Charlton,J., Clark,V. and Bird,A. (1997) Methylation of genomes and genes at the invertebrate-vertebrate boundary. Mol. Cell Biol., 17, 1469-1475.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 1469-1475
    • Tweedie, S.1    Charlton, J.2    Clark, V.3    Bird, A.4
  • 46
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki,M.M. and Bird,A. (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet., 9, 465-476.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 48
    • 76049130688 scopus 로고    scopus 로고
    • The N-terminus of histone H3 is required for de novo DNA methylation in chromatin
    • Hu,J.L., Zhou,B.O., Zhang,R.R., Zhang,K.L., Zhou,J.Q. and Xu,G.L. (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc. Natl Acad. Sci. USA, 106, 22187-22192.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 22187-22192
    • Hu, J.L.1    Zhou, B.O.2    Zhang, R.R.3    Zhang, K.L.4    Zhou, J.Q.5    Xu, G.L.6
  • 49
    • 0034069652 scopus 로고    scopus 로고
    • Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation
    • Gibbons,R.J., McDowell,T.L., Raman,S., O'Rourke,D.M., Garrick,D., Ayyub,H. and Higgs,D.R. (2000) Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat. Genet., 24, 368-371.
    • (2000) Nat. Genet. , vol.24 , pp. 368-371
    • Gibbons, R.J.1    McDowell, T.L.2    Raman, S.3    O'Rourke, D.M.4    Garrick, D.5    Ayyub, H.6    Higgs, D.R.7
  • 54
    • 0038412822 scopus 로고    scopus 로고
    • The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
    • Fuks,F., Hurd,P.J., Deplus,R. and Kouzarides,T. (2003) The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res., 31, 2305-2312.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2305-2312
    • Fuks, F.1    Hurd, P.J.2    Deplus, R.3    Kouzarides, T.4
  • 55
    • 55549141877 scopus 로고    scopus 로고
    • Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
    • Zilberman,D., Coleman-Derr,D., Ballinger,T. and Henikoff,S. (2008) Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature, 456, 125-129.
    • (2008) Nature , vol.456 , pp. 125-129
    • Zilberman, D.1    Coleman-Derr, D.2    Ballinger, T.3    Henikoff, S.4
  • 56
    • 0037992395 scopus 로고    scopus 로고
    • The structure of DNA in the nucleosome core
    • Richmond,T.J. and Davey,C.A. (2003) The structure of DNA in the nucleosome core. Nature, 423, 145-150.
    • (2003) Nature , vol.423 , pp. 145-150
    • Richmond, T.J.1    Davey, C.A.2
  • 57
    • 0028010888 scopus 로고
    • HhaI methyltransferase flips its target base out of the DNA helix
    • Klimasauskas,S., Kumar,S., Roberts,R.J. and Cheng,X. (1994) HhaI methyltransferase flips its target base out of the DNA helix. Cell, 76, 357-369.
    • (1994) Cell , vol.76 , pp. 357-369
    • Klimasauskas, S.1    Kumar, S.2    Roberts, R.J.3    Cheng, X.4
  • 58
    • 51649122492 scopus 로고    scopus 로고
    • Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates
    • Yokoyama,S., Tada,T., Zhang,H. and Britt,L. (2008) Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates. Proc. Natl Acad. Sci. USA, 105, 13480-13485.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 13480-13485
    • Yokoyama, S.1    Tada, T.2    Zhang, H.3    Britt, L.4
  • 59
    • 66149086564 scopus 로고    scopus 로고
    • Reliabilities of identifying positive selection by the branch-site and the site-prediction methods
    • Nozawa,M., Suzuki,Y. and Nei,M. (2009) Reliabilities of identifying positive selection by the branch-site and the site-prediction methods. Proc. Natl Acad. Sci. USA, 106, 6700-6705.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6700-6705
    • Nozawa, M.1    Suzuki, Y.2    Nei, M.3


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