Targeted delivery of molecular probes for in vivo electron paramagnetic resonance imaging

IFMBE Proceedings

Volumn 32 IFMBE, Issue , 2010, Pages 466-469

  Burks, S R ^a,b   Barth, E D ^c   Martin, S S ^a,b   Rosen, G M ^a,b   Halpern, H J ^c   Kao, J P Y ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c University of Chicago   (United States)

Author keywords

Breast cancer; Electron paramagnetic resonance; HER2; Imaging; Liposomes; Nitroxides

Indexed keywords

BREAST CANCER; ELECTRON PARAMAGNETIC RESONANCE; HER2; IMAGING; NITROXIDES;

ANIMALS; BIOMEDICAL ENGINEERING; CONCENTRATION (PROCESS); ELECTRON RESONANCE; ELECTRONS; LIPOSOMES; NITROGEN OXIDES; OPTIMIZATION; PARAMAGNETIC MATERIALS; PARAMAGNETIC RESONANCE; PHOSPHOLIPIDS; PHYSIOLOGY; PROBES; TUMORS; VISUALIZATION;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

EID: 78049412359     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-14998-6_119     Document Type: Conference Paper

References (8)

1. Halpern HJ, Spencer DP, Vanpolen J et al. (1989) Imaging radio-frequency electron-spin-resonance spectrometer with high-resolution and sensitivity for in vivo measurements. Rev Sci Instr 60:1040-1050
2. Rosen GM, Burks SR, Kohr MJ, et al. (2005) Synthesis and biological testing of aminoxyls designed for long-term retention by living cells. Org Biomol Chem 3:645-648
3. Kao JP, Barth ED, Burks SR, et al. (2007) Very-low-frequency electron paramagnetic resonance (EPR) imaging of nitroxide-loaded cells. Magn Reson Med 58:850-854
4. Burks SR, Barth ED, Halpern HJ, et al. (2009) Cellular uptake of electron paramagnetic resonance imaging probes through endocytosis of liposomes. Biochim Biophys Acta 1788:2301-2308
5. Park JW, Kirpotin DB, Hong K, et al. (2001) Tumor targeting using anti-her2 immunoliposomes. J Control Release 74:95-113 (Pubitemid 32727613)
6. Burks SR, Macedo LF, Barth ED, et al. (2010) Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells Breast Cancer Res Treat In Press
7. Woodle MC and Lasic DD. (1992) Sterically stabilized liposomes. Biochim.Biophys.Acta 1113:171-199
8. Kirpotin DB, Drummond DC, Shao Y et al (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66:6732-6740