Misfolding of CasBrE SU is reversed by interactions with 4070A Env: Implications for gammaretroviral neuropathogenesis

Retrovirology

Volumn 7, Issue , 2010, Pages

  Li, Ying ^a,b,c   Lynch, William P ^a,b  

^a Northeastern Ohio Medical University   (United States)

^b KENT STATE UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN MALONYLTRANSFERASE; ENVELOPE PROTEIN; ONCOPROTEIN; POLYPROTEIN; PRION PROTEIN; PROTEIN SUBUNIT; SCAFFOLD PROTEIN; VIRUS PROTEIN; VIRUS VECTOR; VIRUS ENVELOPE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; ECOTROPIC VIRUS; GAMMARETROVIRUS INFECTION; GENE MAPPING; GENETIC TRANSDUCTION; MOUSE; MURINE LEUKEMIA VIRUS; NEURAL STEM CELL; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SUPERINFECTION; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS MORPHOLOGY; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS TRANSMISSION; WESTERN BLOTTING; ANIMAL; CELL LINE; EXPERIMENTAL LEUKEMIA; HELPER VIRUS; METABOLISM; MOTOR NEURON DISEASE; PATHOGENICITY; PHYSIOLOGY; PROTEIN BINDING; RETROVIRUS INFECTION; VIROLOGY; VIRULENCE; VIRUS INFECTION;

MURINE LEUKEMIA VIRUS;

ANIMALS; CELL LINE; GENE PRODUCTS, ENV; HELPER VIRUSES; LEUKEMIA VIRUS, MURINE; LEUKEMIA, EXPERIMENTAL; MICE; MOTOR NEURON DISEASE; NEURAL STEM CELLS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN SUBUNITS; RETROVIRIDAE INFECTIONS; TUMOR VIRUS INFECTIONS; VIRULENCE;

EID: 78049396096     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-7-93     Document Type: Article

References (40)

1. Gardner MB. Retroviral spongiform polioencephalomyelopathy. Rev Infect Dis 1985, 7:99-110.
2. Gardner MB, Henderson BE, Officer JE, Rongey RW, Parker JC, Oliver C, Estes JD, Huebner RJ. A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice. JNCI 1973, 51:1243-1254.
3. Gardner MB, Rasheed S, Klement V, Rongey RW, Brown JC, Dworsky R, Henderson BE. Lower motor neuron disease in wild mice caused by indigenous type C virus and search for a similar etiology in human amyotrophic lateral sclerosis. UCLA Forum Med Sci 1976, 19:217-234.
4. DesGroseillers L, Barrette M, Jolicoeur P. Physical Mapping of the paralysis-inducing determinant of a wild mouse ecotropic neurotropic virus. J Virol 1984, 52:356-363. 254534, 6092665.
5. Jolicoeur P, Gravel C, Kay DG. Pathogenesis of murine spongiform myeloencephalopathy induced by a murine retrovirus. Molecular Neurovirology 1992, 199-224. Totowa, NJ: Humana Press Inc, Roos RP.
6. Portis JL. Genetic determinants of neurovirulence of murine oncornaviruses. Adv Virus Res 2001, 56:3-38. 10.1016/S0065-3527(01)56003-0, 11450304.
7. Portis JL, Lynch WP. Dissecting the determinants of neuropathogenesis of the murine oncornaviruses. Virology 1998, 247:127-136. 10.1006/viro.1998.9240, 9705905.
8. Wong PKY, Yuen PH. Molecular basis of neurologic disorders induced by a mutant ts1, of Moloney murine leukemia virus. Molecular Neurovirology: Pathogenesis of Viral CNS Infections 1992, 161-197. Totowa: Humana Press, Roos R.
9. Murphy SL, Honczarenko MJ, Dugger NV, Hoffman PM, Gaulton GN. Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. J Virol 2004, 78:8392-8399. 10.1128/JVI.78.15.8392-8399.2004, 446142, 15254211.
10. Paquette Y, Hanna Z, Savard P, Brousseau R, Robitaille Y, Jolicoeur P. Retrovirus-induced murine motor neuron disease: Mapping the determinant of spongiform degeneration within the envelope gene. Proc Natl Acad Sci USA 1989, 86:3896-3900. 10.1073/pnas.86.10.3896, 287248, 2542954.
11. Lynch WP, Snyder EY, Qualtiere L, Portis JL, Sharpe AH. Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains. J Virol 1996, 70:8896-8907. 190987, 8971019.
12. Kay DG, Gravel C, Pothier F, Laperriere A, Robitalle Y, Jolicoeur P. Neurological disease induced in transgenic mice expressing the env gene of the Cas-Br-E murine retrovirus. Proc Natl Acad Sci USA 1993, 90:4538-4542. 10.1073/pnas.90.10.4538, 46547, 8389454.
13. Yu YE, Choe W, Zhang W, Stoica G, Wong PK. Development of pathological lesions in the central nervoous system of transgenic mice expressing the env gene of ts1 Moloney murine leukemia virus in the absence of viral gag and pol genes and viral replication. Journal of Neuorvirololgy 1997, 3:274-282.
14. Lynch WP, Sharpe AH, Snyder EY. Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. J Virol 1999, 73:6841-6851. 112769, 10400782.
15. Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, et al. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 2005, 308:1435-1439. 10.1126/science.1110837, 15933194.
16. Albritton LM, Tseng L, Scadden D, Cunningham JM. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell 1989, 57:659-666. 10.1016/0092-8674(89)90134-7, 2541919.
17. Barnett AL, Davey RA, Cunningham JM. Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection. PNAS 2001, 98:4113-4118. 10.1073/pnas.071432398, 31188, 11274436.
18. Snyder EY, Deitcher DL, Walsh C, Arnold-Aldea S, Hartwieg E, Cepko CL. Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 1992, 68:33-51. 10.1016/0092-8674(92)90204-P, 1732063.
19. Flynn JA, An W, King SR, Telesnitsky A. Nonrandom dimerization of murine leukemia virus genomic RNAs. J Virol 2004, 78:12129-12139. 10.1128/JVI.78.22.12129-12139.2004, 525042, 15507599.
20. Davey RA, Hamson CA, Healey JJ, Cunningham JM. In vitro binding of purified murine ecotropic retrovirus envelope surface protein to its receptor, MCAT-1. J Virol 1997, 71:8096-8102. 192264, 9343158.
21. Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM. Structure of a Murine Leukemia Virus Receptor-Binding Glycoprotein at 2.0 Angstrom Resolution. Nature 1997, 277:1662-1666.
22. Lavillette D, Boson B, Russell SJ, Cosset FL. Activation of membrane fusion by murine leukemia viruses is controlled in cis or in trans by interactions between the receptor-binding domain and a conserved disulfide loop of the carboxy terminus of the surface glycoprotein. J Virol 2001, 75:3685-3695. 10.1128/JVI.75.8.3685-3695.2001, 114860, 11264358.
23. Anelli T, Sitia R. Protein quality control in the early secretory pathway. Embo J 2008, 27:315-327. 10.1038/sj.emboj.7601974, 2234347, 18216874.
24. Helenius A, Aebi M. Roles of N-linked glycans in the endoplasmic reticulum. Annu Rev Biochem 2004, 73:1019-1049. 10.1146/annurev.biochem.73.011303.073752, 15189166.
25. Vembar SS, Brodsky JL. One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 2008, 9:944-957. 10.1038/nrm2546, 2654601, 19002207.
26. Gardner MB. Type C viruses of wild mice-Characterization and natural history of amphotropic, ecotropic, and xenotropic MuLV. Curr Top Microbiol Immunol 1978, 79:215-259.
27. Perryman S, Nishio J, Chesebro B. Complete nucleotide sequence of Friend murine leukemia virus, strain FB29. Nucleic Acids Res 1991, 19:6950. 10.1093/nar/19.24.6950, 329334, 1762923.
28. Portis JL, Czub S, Garon CF, McAtee FJ. Neurodegenerative disease induced by the Wild Mouse ecotropic retrovirus is markedly accelerated by long terminal repeat and gag-pol sequences from nondefective Friend murine leukemia virus. J Virol 1990, 64:1648-1656. 249301, 2181155.
29. Kozak SL, Kabat D. Ping-pong amplification of a retroviral vector achieves high level gene expression: human growth hormone production. J Virol 1990, 64:3500-3508. 249616, 2352330.
30. Ryder EF, Snyder EY, Cepko CL. Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. Jounal of Neurobiology 1990, 21:356-375.
31. Miller AD, Law M-F, Verma IM. Generation of helper-free amphtropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Mol Cell Biol 1985, 5:431-437. 366734, 2985952.
32. McAtee FJ, Portis JL. Monoclonal antibodies specific for wild mouse neurotropic retrovirus: Detection of comparable levels of virus replication in mouse strains susceptible and resistent to paralytic disease. J Virol 1985, 56:1010-1022.
33. Lynch WP, Brown WJ, Spangrude GJ, Portis JL. Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles. J Virol 1994, 68:3401-3409. 236834, 8151801.
34. Czub M, Czub S, McAtee F, Portis J. Age-dependent resistance to murine retrovirus-induced spongiform neurodegeneration results from CNS-specific restriction of virus replication. J Virol 1991, 65:2539-2544. 240610, 1850027.
35. Evans LH, Morrison RP, Malik FG, Portis J, Britt WJ. A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia viruses. J Virol 1990, 64:6176-6183. 248792, 1700832.
36. Czub M, McAtee FJ, Portis JL. Murine retrovirus-induced spongiform encephalomyelopathy: host and viral factors which determine the length of the incubation period. J Virol 1992, 66:3298-3305. 241107, 1316449.
37. Miller AD, Wolgamot G. Murine retroviruses use at least six different receptors for entry into Mus dunni cells. J Virol 1997, 71:4531-4535. 191674, 9151846.
38. Chesebro B, Britt W, Evans L, Wehrly K, Nishio J, Cloyd M. Characterization of monoclonal antibodies reactive with murine leukemia viruses: use in analysis of strains of friend MCF and Friend ecotropic murine leukemia virus. Virology 1983, 127:134-148. 10.1016/0042-6822(83)90378-1, 6305011.
39. Robertson MN, Miyazawa M, Mori S, Caughey B, Evans LH, Hayes SF, Chesebro B. Production of monoclonal antibodies reactive with a denatured form of the Friend murine leukemia virus gp70 envelope protein: use in a focal infectivity assay, immunohistochemical studies, electron microscopy and western blotting. J Virol Methods 1991, 34:255-271. 10.1016/0166-0934(91)90105-9, 1744218.
40. Lynch WP, Sharpe AH. Differential glycosylation of the Cas-Br-E env protein is associated with retrovirus-induced spongiform neurodegeneration. J Virol 2000, 74:1558-1565. 10.1128/JVI.74.3.1558-1565.2000, 111494, 10627570.