Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and cytokine levels in atopic dermatitis NC/Nga mice

Journal of Ethnopharmacology

Volumn 132, Issue 2, 2010, Pages 529-532

  Kim, Jinkyung ^a   Lee, In seok ^a   Park, Soojin ^b   Choue, Ryowon ^a  

^a Kyung Hee University   (South Korea)

^b Semyung University   (South Korea)

Author keywords

Aloe vera gel; Atopic dermatitis; Cytokines; IgE; Scutellariae radix

Indexed keywords

ALOE VERA EXTRACT; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; SCUTELLARIAE RADIX; TUMOR NECROSIS FACTOR ALPHA;

ALOE VERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; TREATMENT OUTCOME;

ALOE; ANIMALS; CYTOKINES; DERMATITIS, ATOPIC; IMMUNOGLOBULIN E; IMMUNOLOGIC FACTORS; MALE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; SCUTELLARIA BAICALENSIS; SKIN;

ALOE VERA; MUS; SCUTELLARIA RADIX;

EID: 78049391894     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.08.049     Document Type: Article

References (17)

1. Aioi A., Tonogaito H., Suto H., Hamada K., Ra C., Ogawa H., Maibach H., Matsuda H. Impairment of skin barrier function in NC/Nga Tnd mice as a possible model for atopic dermatitis. British Journal of Dermatology 2001, 144:12-18.
2. Chen L., Lin S.X., Overbergh L., Mathieu C., Chan L.S. The disease progression in the keratin14 IL-4-transgenic mouse model of atopic dermatitis parallels the up-regulation of B cell activation molecules, proliferation and surface and serum IgE. Clinical & Experimental Immunology 2005, 142:21-30.
3. Choi S., Chung M. A review on the relationship between Aloe vera components and their biologic effects. Seminars in Integrative Medicine 2003, 1:53-62.
4. Cosmetic Ingredient Review Expert Panel Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice, and Aloe ferox leaf juice extract. International Journal of Toxicology 2007, 26:1-50.
5. Habeeb F., Stables G., Bradbury F., Nong S., Cameron P., Plevin R., Ferro V.A. The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods 2007, 42:388-393.
6. Jin H., He R., Oyoshi M., Geha R.S. Animal models of atopic dermatitis. Journal of Investigative Dermatology 2009, 29:31-40.
7. Langmead L., Feakins R.M., Goldthorpe S., Holt H., Tsironi E., De Silva A., Jewell D.P., Rampton D.S. Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel for active ulcerative colitis. Alimentary Pharmacology & Therapeutics 2004, 19:739-747.
8. Laouini D., Alenius H., Bryce P., Oettgen H., Tsitsikov E., Geha R.S. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. The Journal of Clinical Investigation 2003, 112:1058-1066.
9. Leung D.Y., Boguniewicz M., Howell M.D., Nomura I., Hamid Q.A. New insights into atopic dermatitis. The Journal of Clinical Investigation 2004, 113:651-657.
10. Lim B.O. Effect of ganhuangenin obtained from Scutellaria radix on the chemical mediator production of peritoneal exudate cells and immunoglobulin E level of mesenteric lymph node lymphocytes in Sprague-Dawley rats. Phytotherapy Research 2002, 16:166-170.
11. Lim B.O. Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. Bioscience, Biotechnology, and Biochemistry 2004, 68:2505-2511.
12. Matsuda H., Watanabe N., Geba G.P., Sperl J., Tsudzuki M., Hiroi J., Matsumoto M., Ushio H., Saito S., Askenase P.W., Ra C. Development of atopic dermatitis-like skin lesion with IgE hyperproduction NC/Nga mice. International Immunology 1997, 9:3461-3488.
13. Matsumoto M., Ra C., Kawamoto K., Sato H., Itakura A., Sawada J., Ushio H., Suto H., Mitsuishi K., Hikasa Y., Matsuda H. IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. The Journal of Immunology 1999, 162:1056-1063.
14. Novak N., Bieber T., Leung D.Y. Immune mechanisms leading to atopic dermatitis. Journal of Allergy and Clinical Immunology 2003, 112:S128-134.
15. Park S., Hahm K.B., Oh T.Y., Jin J.H., Choue R. Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Digestive Diseases and Sciences 2004, 49:384-394.
16. Vazquez B., Avila G., Segura D., Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. Journal of Ethnopharmacology 1996, 55:69-75.
17. Yagi R., Nagai H., Iigo Y., Akimoto T., Arai T., Kubo M. Development of atopic dermatitis-like skin lesions in STAT6-deficient NC/Nga mice. The Journal of Immunology 2002, 168:2020-2027.