Mechanisms of poly(amido amine) dendrimer transepithelial transport and tight junction modulation in caco-2 cells

IFMBE Proceedings

Volumn 32 IFMBE, Issue , 2010, Pages 236-239

  Goldberg, D S ^a   Swaan, P W ^a,b   Ghandehari, H ^a,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c Center for Nanomedicine   (United States)

Author keywords

endocytosis; oral drug delivery; PAMAM dendrimers; tight junctions; transport

Indexed keywords

ENDOCYTOSIS; ORAL DRUG DELIVERY; PAMAM DENDRIMERS; TIGHT JUNCTIONS; TRANSPORT;

BIOMEDICAL ENGINEERING; DRUG DELIVERY; LIVING SYSTEMS STUDIES; MODULATION; MOLECULAR BIOLOGY; MONOLAYERS; ORGANIC COMPOUNDS; PROTEINS;

DENDRIMERS;

EID: 78049367181     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-14998-6_60     Document Type: Conference Paper

References (4)

1. Kolhatkar R, Sweet D, Ghandehari H. (2008) Functionalized Dendrimers as Nanoscale Drug Carriers, in Multifunctional Pharmaceutical Nanocarriers, Springer, 201-232.
2. Kitchens K, Foraker A, Kolhatkar R et al (2007) Endocytosis and interaction of poly (amidoamine) dendrimers with Caco-2 Cells. Pharm Res, 24: 2138-2145.
3. Kitchens K, Kolhatkar R, Swaan P et al (2008) Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells. Mol Pharm, 5:364-369.
4. Torgersen M, Skretting G, van Deurs B et al. (2001) Internalization of cholera toxin by different endocytic mechanisms. J Cell Sci, 114:3737-3747.