Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

Journal of Endocrinology

Volumn 207, Issue 2, 2010, Pages 177-183

  Roubert, Pierre ^a   Dubern, Béatrice ^b,c,d   Plas, Pascale ^a   Lubrano Berthelier, Cécile ^b,d   Alihi, Rohia ^b,d   Auger, Florence ^a   Deoliveira, Daniel B ^e   Dong, Jesse Z ^e   Basdevant, Arnaud ^b,d   Thurieau, Christophe ^a   Clément, Karine ^b,d  

^a IPSEN   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c ARMAND TROUSSEAU HOSPITAL   (France)

^d INSERM   (France)

^e Biomeasure Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; IRC 022493; IRC 022511; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; DRUG BINDING SITE; DRUG INHIBITION; DRUG RECEPTOR BINDING; GENE MUTATION; HUMAN; IN VITRO STUDY; NONHUMAN; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; RAT; SCHOOL CHILD; WILD TYPE;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANIMALS; CHILD; CHILD, PRESCHOOL; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; CYCLIC AMP; DRUG DESIGN; HUMANS; MELANOCORTINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; OBESITY; PROTEIN BINDING; RECEPTOR, MELANOCORTIN, TYPE 4; YOUNG ADULT;

EID: 78049357000     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0336     Document Type: Article

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