Intrathecal injection of hepatocyte growth factor gene-modified marrow stromal cells attenuates neurologic injury induced by transient spinal cord ischemia in rabbits

Anesthesiology

Volumn 113, Issue 5, 2010, Pages 1109-1117

  Shi, Enyi ^a   Jiang, Xiaojing ^a   Wang, Lingling ^a   Akuzawa, Satoshi ^b   Nakajima, Yoshiki ^b   Kazui, Teruhisa ^c  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Department of Anesthesiology ^*  (China)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PENTOBARBITAL; SCATTER FACTOR; HGF PROTEIN, HUMAN; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BRAIN INJURY; CELL MIGRATION; CELL TRANSPLANTATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; HISTOLOGY; LUMBAR SPINAL CORD; MOTOR PERFORMANCE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD ISCHEMIA; STROMA CELL; ANIMAL; BONE MARROW TRANSPLANTATION; CELL CULTURE; COMPARATIVE STUDY; GENETICS; HUMAN; INTRASPINAL DRUG ADMINISTRATION; PATHOLOGY; PROCEDURES; RANDOMIZATION; REPERFUSION INJURY; TRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; HEPATOCYTE GROWTH FACTOR; HUMANS; INJECTIONS, SPINAL; NEUROPROTECTIVE AGENTS; RABBITS; RANDOM ALLOCATION; REPERFUSION INJURY; SPINAL CORD ISCHEMIA; STROMAL CELLS;

EID: 78049329501     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181f6970d     Document Type: Article

References (29)

1. Coselli JS, LeMaire SA, Miller CC 3rd, Schmittling ZC, Köksoy C, Pagan J, Curling PE: Mortality and paraplegia after thoracoabdominal aortic aneurysm repair: A risk factor analysis. Ann Thorac Surg 2000; 69:409-14
2. Safi HJ, Miller CC 3rd, Huynh TT, Estrera AL, Porat EE, Winnerkvist AN, Allen BS, Hassoun HT, Moore FA: Distal aortic perfusion and cerebrospinal fluid drainage for tho-racoabdominal and descending thoracic aortic repair: Ten years of organ protection. Ann Surg 2003; 238:372-80
3. Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T: Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 1987; 224:311-6
4. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K, Shimizu S: Molecular cloning and expression of human hepatocyte growth factor. Nature 1989; 342:440-3
5. Honda S, Kagoshima M, Wanaka A, Tohyama M, Matsu-moto K, Nakamura T: Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: Implication as neurotrophic factor. Brain Res Mol Brain Res 1995; 32: 197-210
6. Korhonen L, Sjöholm U, Takei N, Kern MA, Schirmacher P, Castrén E, Lindholm D: Expression of c-Met in developing rat hippocampus: Evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons. Eur J Neurosci 2000; 12:3453-61
7. Shi E, Jiang X, Kazui T, Washiyama N, Yamashita K, Terada H, Bashar AH: Nonviral gene transfer of hepatocyte growth factor attenuates neurologic injury after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 2006; 132:941-7
8. Lennon DP, Haynesworth SE, Young RG, Dennis JE, Caplan AI: A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. Exp Cell Res 1995; 219:211-22
9. Honma T, Honmou O, Iihoshi S, Harada K, Houkin K, Hamada H, Kocsis JD: Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat. Exp Neurol 2006; 199:56-66
10. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M: Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neu-rol Sci 2001; 189:49-57 (Pubitemid 32776649)
11. Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M: Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 2003; 92:692-9
12. Shi E, Kazui T, Jiang X, Washiyama N, Yamashita K, Terada H, Bashar AH: Intrathecal injection of bone marrow stro-mal cells attenuates neurologic injury after spinal cord ischemia. Ann Thorac Surg 2006; 81:2227-33
13. Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, Houkin K, Date I, Hamada H: BDNF gene-modified mesen-chymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther 2004; 9:189-97
14. Onda T, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD: Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J Cereb Blood Flow Metab 2008; 28: 329-40
15. Toyama K, Honmou O, Harada K, Suzuki J, Houkin K, Hamada H, Kocsis JD: Therapeutic benefits of angioge-netic gene-modified human mesenchymal stem cells after cerebral ischemia. Exp Neurol 2009; 216:47-55
16. Zhao MZ, Nonoguchi N, Ikeda N, Watanabe T, Furutama D, Miyazawa D, Funakoshi H, Kajimoto Y, Nakamura T, Dezawa M, Shibata MA, Otsuki Y, Coffin RS, Liu WD, Kuroiwa T, Miyatake S: Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. J Cereb Blood Flow Metab 2006; 26:1176-88
17. Shi E, Jiang X, Kazui T, Washiyama N, Yamashita K, Terada H, Bashar AH: Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia. J Thorac Cardiovasc Surg 2007; 133: 942-8
18. Suzuki K, Kazui T, Terada H, Umemura K, Ikeda Y, Bashar AH, Yamashita K, Washiyama N, Suzuki T, Ohkura K, Yasuike J: Experimental study on the protective effects of edaravone against ischemic spinal cord injury. J Thorac Cardiovasc Surg 2005; 130:1586-92
19. Kato N, Nemoto K, Nakanishi K, Morishita R, Kaneda Y, Uenoyama M, Ikeda T, Fujikawa K: Nonviral HVJ (hemag-glutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve. Neurosci Res 2005; 52:299-310
20. Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R: Novel therapeutic strategy to treat brain ischemia: Over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation 2004; 109:424-31
21. Tarlov IM: Acute spinal cord compression paralysis. J Neu-rosurg 1972; 36:10-20
22. Mutch WA, Graham MR, Halliday WC, Thiessen DB, Girling LG: Use of neuroanesthesia adjuncts (hyperventilation and mannitol administration) improves neurological outcome after thoracic aortic cross-clamping in dogs. Stroke 1993; 24:1204-10
23. Shi E, Kazui T, Jiang X, Washiyama N, Yamashita K, Terada H, Bashar AH: Therapeutic benefit of intrathecal injection of marrow stromal cells on ischemia-injured spinal cord. Ann Thorac Surg 2007; 83:1484-90
24. Kaneda Y, Nakajima T, Nishikawa T, Yamamoto S, Ikegami H, Suzuki N, Nakamura H, Morishita R, Kotani H: Hemag-glutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system. Mol Ther 2002; 6:219-26
25. Zhang Q, Li Y, Shi Y, Zhang Y: HVJ envelope vector, a versatile delivery system: Its development, application, and perspectives. Biochem Biophys Res Commun 2008; 373:345-9
26. 2+ channel blocker, prevents neurologic injury after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 2005; 129:364-71
27. Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, Lu M, Rosenblum M: Spinal cord injury in rat: Treatment with bone marrow stromal cell transplantation. Neuroreport 2000; 11:3001-5
28. Yoshimura S, Morishita R, Hayashi K, Kokuzawa J, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Sakai N, Kaneda Y: Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model. Hypertension 2002; 39:1028-34
29. Chopp M, Li Y: Treatment of neural injury with marrow stromal cells. Lancet Neurol 2002; 1:92-100