Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: Methodologic considerations

Journal of Clinical Epidemiology

Volumn 63, Issue 12, 2010, Pages 1312-1323

  Zucker, Deborah R ^a   Ruthazer, Robin ^a   Schmid, Christopher H ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Comparative effectiveness; Comparisons; Meta analysis; Methodology; N of 1 trials; Population estimate

Indexed keywords

AMITRIPTYLINE; FLUOXETINE;

ACCURACY; ARTICLE; AVERAGED OUTCOME CROSSOVER MODEL; BAYESIAN HIERARCHICAL MODEL; CLINICAL TRIAL; CONTROLLED STUDY; COVARIANCE; FIBROMYALGIA; HUMAN; INTERMETHOD COMPARISON; METHODOLOGY; PRIORITY JOURNAL; RANDOM EFFECT MODEL; REPEATED MEASURE MODEL; SINGLE PAIR MODEL; SINGLE PERIOD MODEL; STATISTICAL MODEL; THERAPY EFFECT;

AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS; BAYES THEOREM; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; DRUG THERAPY, COMBINATION; FLUOXETINE; HUMANS; INDIVIDUALIZED MEDICINE; META-ANALYSIS AS TOPIC; MODELS, STATISTICAL; OUTCOME ASSESSMENT (HEALTH CARE); RESEARCH DESIGN;

EID: 78049312194     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2010.04.020     Document Type: Article

References (27)

1. G. Guyatt, D. Sackett, D.W. Taylor, J. Chong, R. Roberts, and S. Pugsley Determining optimal therapy randomized trials in individual patients N Engl J Med 314 1986 889 892 (Pubitemid 16126117)
2. D.R. Zucker, C.H. Schmid, M.W. McIntosh, R.B. D'Agostino, H.P. Selker, and J. Lau Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment J Clin Epidemiol 50 1997 401 410
3. L. March, L. Irwig, J. Schwarz, J. Simpson, C. Chock, and P. Brooks n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis BMJ 309 1994 1041 1045
4. R. Jaeschke, J. Adachi, G. Guyatt, J. Keller, and B. Wong Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials J Rheumatol 18 1991 447 451
5. D.R. Zucker, R. Ruthazer, C.H. Schmid, J.M. Feuer, P.A. Fischer, and R.I. Kieval Lessons learned combining N-of-1 trials to assess fibromyalgia therapies 1 J Rheumatol 33 2006 2069 2077
6. J.L. Mahon, A. Laupacis, R.V. Hodder, D.A. McKim, N.A. Paterson, and T.E. Wood Theophylline for irreversible chronic airflow limitation: a randomized study comparing n of 1 trials to standard practice Chest 115 1999 38 48
7. T. Johannessen, H. Petersen, P. Kristensen, D. Fosstvedt, P.M. Kleveland, and J. Dybdahl Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials Scand J Gastroenterol 27 1992 189 195
8. G.H. Guyatt, J.L. Keller, R. Jaeschke, D. Rosenbloom, J.D. Adachi, and M.T. Newhouse The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience Ann Intern Med 112 1990 293 299
9. E.B. Larson, A.J. Ellsworth, and J. Oas Randomized clinical trials in single patients during a 2-year period JAMA 270 1993 2708 2712
10. G. Guyatt, A. Heyting, R. Jaeschke, J. Keller, J. Adachi, and R. Roberts N of 1 randomized trials for investigating new drugs Control Clin Trials 11 1990 88 100 (Pubitemid 20136183)
11. G. Guyatt, D. Sackett, J. Adachi, R. Roberts, J. Chong, and D. Rosenbloom A clinician's guide for conducting randomized trials in individual patients CMAJ 139 1988 497 503
12. A.L. Avins, S. Bent, and J.M. Neuhaus Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study Contemp Clin Trials 26 2005 397 401
13. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
14. A. Whitehead Meta-analysis of controlled clinical trials 2002 Wiley West Sussex, UK
15. A. Whitehead, R.Z. Omar, J.P. Higgins, E. Savaluny, R.M. Turner, and S.G. Thompson Meta-analysis of ordinal outcomes using individual patient data Stat Med 20 2001 2243 2260
16. J.P. Higgins, A. Whitehead, R.M. Turner, R.Z. Omar, and S.G. Thompson Meta-analysis of continuous outcome data from individual patients Stat Med 20 2001 2219 2241 (Pubitemid 32725503)
17. A.P. Jones, R.D. Riley, P.R. Williamson, and A. Whitehead Meta-analysis of individual patient data versus aggregate data from longitudinal clinical trials Clin Trials 6 2009 16 27
18. K.J. Ishak, R.W. Platt, L. Joseph, J.A. Hanley, and J.J. Caro Meta-analysis of longitudinal studies 1 Clin Trials 4 2007 525 539
19. C.S. Burckhardt, S.R. Clark, and R.M. Bennett The fibromyalgia impact questionnaire: development and validation J Rheumatol 18 1991 728 733
20. W.G. Cochrane The combination of estimates from different experiments Biometrics 10 1954 101 129
21. J.D. Singer, and J.B. Willett Applied longitudinal data analysis: modeling change and event occurrence 2003 Oxford University Press New York
22. G. Schwarz Estimating the dimension of a model Ann Stat 6 1978 461 464
23. D. Goldenberg, M. Mayskiy, C. Mossey, R. Ruthazer, and C. Schmid A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia Arthritis Rheum 39 1996 1852 1859
24. A. Gelman Prior distributions for variance parameters in hierarchical models Bayesian Anal 1 2006 515 533
25. S. Senn Cross-over trials in clinical research 1st edition 1993 J. Wiley Chichester; New York
26. J. Lau, C.H. Schmid, and T.C. Chalmers Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care J Clin Epidemiol 48 1995 45 57
27. A. Gelman, and J. Hill Data analysis using regression and multilevel/hierarchical models 2007 Cambridge University Press Cambridge, NY