Diastereoselective reduction of 1-(4-fluorophenyl)-3(R)-[3-oxo-3-(4- fluorophenyl)-propyl]-4(S)-(4-hydroxyphenyl)azetidin-2-one to Ezetimibe by the whole cell catalyst Rhodococcus fascians MO22

Journal of Molecular Catalysis B: Enzymatic

Volumn 67, Issue 3-4, 2010, Pages 266-270

  Kyslíková, Eva ^a   Babiak, Peter ^b   Marešová, Helena ^a   Palyzová, Andrea ^a   Hájíček, Josef ^b   Kyslík, Pavel ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b Zentiva Prague   (Czech Republic)

Author keywords

Biotransformation; Ezetimibe; Reduction; Rhodococcus fascians MO22

Indexed keywords

BIOREDUCTIONS; BIOTRANSFORMATION; CATALYTIC CAPABILITY; CHEMICAL SYNTHESIS; DIASTEREOSELECTIVE REDUCTION; EZETIMIBE; MICROBIAL REDUCTION; RHODOCOCCUS FASCIANS; WHOLE CELL;

KETONES; SYNTHESIS (CHEMICAL);

BIOCONVERSION;

1 (4 FLUOROPHENYL) [3 OXO 3 (4 FLUOROPHENYL)PROPYL] (4 HYDROXYPHENYL)AZETIDIN 2 ONE; AZETIDINE DERIVATIVE; EZETIMIBE; KETONE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOTRANSFORMATION; CATALYST; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TRANSFORMATION; MICROORGANISM; NONHUMAN; REDUCTION KINETICS; RHODOCOCCUS; RHODOCOCCUS FASCIANS; STEREOCHEMISTRY; WHOLE CELL;

RHODOCOCCUS FASCIANS;

EID: 78049298656     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2010.09.006     Document Type: Article

References (18)

1. A.L. Catapano Eur. Heart J. Suppl. 3 Suppl. E 2001 E6
2. W.J. Clader J. Med. Chem. 47 2004 1
3. W. Guangzhong, Y. Wong, X. Chen, and D. Zhixian J. Org. Chem. 64 1999 3714
4. M. Slavíková, P. Velíšek, I. Obadalová, and J. Hájiček PCT Int. Appl. 2008 WO 2008106900
5. C. Srinivasan, R. Saxena, P. Gupta, and L. Wandhava PCT Int. Appl. 2008 WO 2008096372
6. M. Homann, E. Previte, N. Brunswick, US 5,618,707 (1997).
7. K. Goldberg, K. Schroer, S. Lütz, and A. Liese Appl. Microbiol. Biotechnol. 76 2007 237
8. K. Goldberg, K. Schroer, S. Lütz, and A. Liese Appl. Microbiol. Biotechnol. 76 2007 249
9. K. Nakamura, R. Yamanaka, T. Matsuda, and T. Harada Tetrahedron: Asymmetry 14 2003 2659
10. A.L. Margolin Enzyme Microb. Technol. 15 1993 266
11. R.N. Patel Coord. Chem. Rev. 252 2008 659
12. Y. Asano J. Biotechnol. 94 2002 65
13. Food & Drug Administration Chirality 4 1992 338
14. M. Kotik, J. Břicháč, and P. Kyslik J. Biotechnol. 120 2005 364
15. R.N. Patel, A. Goswami, L. Chu, M.L. Donovan, V. Nanduri, S. Goldberg, R. Johnston, P.J. Siva, B. Nielsen, J. Fan, W.X. He, Z. Shi, K.Y. Wang, R. Eiring, D. Cazzulino, A. Singh, and R. Mueller Tetrahedron: Asymmetry 15 2004 1247
16. O.P. Ward, and C.S. Young Enzyme Microb. Technol. 12 1990 482
17. P. Soni, and U. Benerjee Biotechnol. J. 1 2006 80
18. R. Machielsen, A.R. Uria, W.M. Kengen, and Van der Oost J. Appl. Environ. Microbiol. 72 2006 233