Cytomegalovirus as a trigger for systemic lupus erythematosus

Journal of Clinical Rheumatology

Volumn 16, Issue 7, 2010, Pages 335-337

  Pérez Mercado, Arnaldo E ^a   Vilá Pérez, Salvador ^a  

^a Dr Ramón Ruiz Arnau University Hospital   (Puerto Rico)

Author keywords

anti dsDNA; anti Sm RNP; CMV IgG; CMV IgM; Cytomegalovirus; herpesvirus; molecular mimicry; mononucleosis; systemic lupus erythematosus; T cell cross reactivity; viral syndrome

Indexed keywords

ANTINUCLEAR ANTIBODY; CARDIOLIPIN ANTIBODY; COMPLEMENT; DOUBLE STRANDED DNA ANTIBODY; GANCICLOVIR; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN M; IRBESARTAN; METHYLPREDNISOLONE; PREDNISONE; RHEUMATOID FACTOR; SM ANTIBODY;

ADULT; ARTICLE; CASE REPORT; CERVICAL LYMPHADENOPATHY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE EXACERBATION; DRUG DOSE REDUCTION; FEVER; FOLLOW UP; HUMAN; HYPERTENSION; HYPOCOMPLEMENTEMIA; LEUKOPENIA; LIVER DYSFUNCTION; MACULOPAPULAR RASH; MALE; MONONUCLEOSIS; PRIORITY JOURNAL; PROTEINURIA; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; CYTOMEGALOVIRUS INFECTIONS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE;

EID: 78049291275     PISSN: 10761608     EISSN: None     Source Type: Journal    
DOI: 10.1097/RHU.0b013e3181f4cf52     Document Type: Article

References (15)

1. Taylor G. Cytomegalovirus. Am Fam Physician 2003;67(3):519-524.
2. Hayashi T, Lee S, Ogasawara H, et al. Exacerbation of systemic lupus erythematosus related to cytomegalovirus infection. Lupus 1998;7(8): 561-564.
3. Tsaparas YF, Brigden ML, Mathias R, et al. Proportion positive for Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, Toxoplasma, and human immunodeficiency virus types 1 and 2 in heterophil negative patients with an absolute lymphocytosis or an instrument-generated atypical lymphocyte flag. Arch Pathol Lab Med 2000;124:1324-1330.
4. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277.
5. Kasapcopur O, Ergul Y, Kutlug S, et al. Systemic lupus erythematosus due to Epstein-Barr virus or Epstein-Barr virus infection provocating acute exacerbation of systemic lupus erythematosus? Rheumatol Int 2006;26:765-767.
6. Gross A, Hochberg D, Rand W, et al. EBV and systemic lupus erythematosus: a new perspective. J Immunol 2005;174:6599-6607.
7. Eguchi K. Systemic lupus erythematosus complicated by cytomegalovirus-induced hemophagocytic syndrome and colitis. Intern Med 2002;41(2):77-78.
8. Schlingemann R, Wertheim-van Dillen P, Kijlstra A, et al. Bilateral cytomegalovirus retinitis in a patient with systemic lupus erythematosus. Br J Ophthalmol 1996;80(12):1109-1110.
9. Tokunaga Y, Takenaka K, Asayama R, et al. Cytomegalovirus-induced interstitial pneumonitis in a patient with systemic lupus erythematosus. Intern Med 1996;35(6):517-520.
10. Nawata M, Seta N, Yamada M, et al. Possible triggering effect of cytomegalovirus infection on systemic lupus erythematosus. Scand J Rheumatol 2001;30:360-362.
11. Harley, JB. The curiously suspicious: a role for Epstein-Barr virus in lupus. Lupus 2006;15:768-777.
12. Price P, Olver S, Gibbons A, et al. B-cell activation following murine cytomegalovirus infection: implications for autoimmunity. Immunology 1993;78:14-21.
13. Chang M, Pan MR, Chen DY, et al. Human cytomegalovirus pp65 lower matrix protein: a humoral immunogen for systemic lupus erythematosus patients and autoantibody accelerator for NZB/W F1 mice. Clin Exp Immunol 2006;143:167-179.
14. Hiemstra H, Schloot N, Van Veelen P, et al. Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 2001;98(7): 3988-3991.
15. Newkirk MM, Van Venrooij WJ, Marshall GS. Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection. Arthritis Res 2001;3(4):253-258.