EMR-3: A potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target

NeuroReport

Volumn 21, Issue 16, 2010, Pages 1018-1022

  Kane, Ari J ^a   Sughrue, Michael E ^a   Rutkowski, Martin J ^a   Phillips, Joanna J ^b   Parsa, Andrew T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

EGF module containing mucin like hormone receptor 3; glioma; invasion

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROTEIN EMR 3; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER SURVIVAL; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DIAGNOSIS, DIFFERENTIAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; NEOPLASM INVASIVENESS; PHENOTYPE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RNA INTERFERENCE; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 78049288580     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32833f19f2     Document Type: Article

References (11)

1. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001; 95:190-198.
2. Parsa AT, Wachhorst S, Lamborn KR, Prados MD, McDermott MW, Berger MS, et al. Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults. J Neurosurg 2005; 102:622-628.
3. Yona S, Lin HH, Siu WO, Gordon S, Stacey M. Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem Sci 2008; 33:491-500.
4. Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, et al. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J Leukoc Biol 2007; 81:440-448.
5. Health NIo. tcga.cancer.gov/. 2009.
6. Sughrue ME, Rutkowski MJ, Kane AJ, Fang S, Parsa AT. Human glioma demonstrates cell line specific results with ATP-based chemiluminescent cellular proliferation assays. J Clin Neurosci 2010 (in press).
7. Yona S, Lin HH, Dri P, Davies JQ, Hayhoe RP, Lewis SM, et al. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J 2008; 22:741-751.
8. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem 2001; 276:18863-18870.
9. Stacey M, Chang GW, Davies JQ, Kwakkenbos MJ, Sanderson RD, Hamann J, et al. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood 2003; 102:2916-2924.
10. Chang GW, Davies JQ, Stacey M, Yona S, Bowdish DM, Hamann J, et al. CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells. Biochem Biophys Res Commun 2007; 353:133-138.
11. Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, et al. Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas. Cancer Epidemiol Biomarkers Prev 2005; 14:108-119.