Perfusion CT in solid body-tumours part II. Clinical applications and future development;La TC perfusionale nei tumori solidi del corpo parte II. Applicazioni cliniche e prospettive

Radiologia Medica

Volumn 115, Issue 6, 2010, Pages 858-874

  Bellomi, M ^a,b   Viotti, S ^b   Preda, L ^a   D'Andrea, G ^b   Bonello, L ^a   Petralia, G ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

CT perfusion; Kinetic models; Oncology; Prediction of tumour response to theraphy; Solid body tumours; Therapy monitoring

Indexed keywords

ARTICLE; COLORECTAL TUMOR; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FEMALE GENITAL TRACT TUMOR; HEAD AND NECK TUMOR; HUMAN; IMAGE PROCESSING; KIDNEY TUMOR; LIVER TUMOR; LUNG TUMOR; MALE; METHODOLOGY; NEOPLASM; PANCREAS TUMOR; PREDICTION AND FORECASTING; PROSTATE TUMOR; RADIOGRAPHY; SCINTIGRAPHY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY;

COLORECTAL NEOPLASMS; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KIDNEY NEOPLASMS; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; NEOPLASMS; OTORHINOLARYNGOLOGIC NEOPLASMS; PANCREATIC NEOPLASMS; PERFUSION IMAGING; PREDICTIVE VALUE OF TESTS; PROSTATIC NEOPLASMS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 78049282792     PISSN: 00338362     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11547-010-0545-9     Document Type: Article

References (83)

1. T.Y. Lee T.G. Purdie E. Stewart 2003 CT imaging of angiogenesis Q J Nucl Med 47 171 187 12897709
2. M.A. Konerding E. Fait A. Gaumann 2001 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon Br J Cancer 84 1354 1362 10.1054/bjoc.2001.1809 11355947 (Pubitemid 32522104)
3. Y. Li Z.G. Yang T.W. Chen 2008 Peripheral lung carcinoma: correlation of angiogenesis and first-pass perfusion parameters of 64-detector row CT Lung Cancer 61 44 53 10.1016/j.lungcan.2007.10.021 18055062 (Pubitemid 351862323)
4. S.H. Ma H.B. Le B.H. Jia 2008 Peripheral pulmonary nodules: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and VEGF expression BMC Cancer 8 186 10.1186/1471-2407-8-186 18590539
5. G. d'Assignies A. Couvelard S. Bahrami 2009 Pancreatic endocrine tumors: tumor blood flow assessed with perfusion CT reflects angiogenesis and correlates with prognostic factors Radiology 250 407 416 10.1148/radiol.2501080291 19095784
6. S.T. Feng C.H. Sun Z.P. Li 2008 Evaluation of microvessel density and vascular endothelial growth factor in colorectal carcinoma with 64-multidetector-row CT perfusion imaging Zhonghua Wei Chang Wai Ke Za Zhi 11 537 541 19031129
7. C.G. Willett Y. Boucher E. di Tomaso 2004 Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Nat Med 10 145 147 10.1038/nm988 14745444 (Pubitemid 38524883)
8. Z.P. Li Q.F. Meng C.H. Sun 2005 Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation World J Gastroenterol 11 1287 1291 15761965
9. M. Bellomi G. Petralia A. Sonzogni 2007 CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience Radiology 244 486 493 10.1148/radiol.2442061189 17641369 (Pubitemid 47080881)
10. D.V. Sahani N.S. Holalkere P.R. Mueller A.X. Zhu 2007 Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue-initial experience Radiology 243 736 743 10.1148/radiol.2433052020 17517931 (Pubitemid 46799427)
11. D.V. Sahani S.P. Kalva L.M. Hamberg 2005 Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: initial observations Radiology 234 785 792 10.1148/radiol.2343040286 15734934 (Pubitemid 40250822)
12. I. Sitarchouk H.C. Roberts A.M. Pereira 2008 Computed tomography perfusion using first pass methods for lung nodule characterization Invest Radiol 43 349 358 10.1097/RLI.0b013e3181690148 (Pubitemid 351769892)
13. G. Petralia L. Preda G. Giugliano 2009 Perfusion computed tomography for monitoring induction chemotherapyin patients with squamous cellcarcinoma of the upper aerodigestivetract: correlation between changes intumor perfusion and tumor volume J Comput Assist Tomogr 33 552 559 10.1097/RCT.0b013e31818d446e 19638848
14. S. Bisdas M. Baghi J. Wagenblast 2007 Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results Eur J Radiol 64 258 265 10.1016/j.ejrad.2007.02.032 17399933 (Pubitemid 47588748)
15. J. Folkman 1971 Tumor angiogenesis: therapeutic implications N Engl J Med 285 1182 1186 10.1056/NEJM197108122850711 4938153
16. K.A. Miles 1999 Tumour angiogenesis and its relation to contrast enhancement on computed tomography: a review Eur J Radiol 30 198 205 10.1016/S0720-048X(99)00012-1 10452718 (Pubitemid 29343737)
17. P.E. Dugdale K.A. Miles 1999 CT measurement of perfusion and permeability within lymphoma masses and its ability to assess grade, activity, and chemotherapeutic response J Comput Assist Tomogr 23 540 547 10.1097/00004728- 199907000-00010 10433282 (Pubitemid 29337146)
18. S.K. Ellika R. Jain 2007 Role of perfusion CT in glioma grading and comparison with conventional MR imaging features J Comput Assist Tomogr 28 1981 1987
19. P.V. Pandharipande G.A. Krinsky H. Rusinek V.S. Lee 2005 Perfusion imaging of the liver: current challenges and future goals Radiology 234 661 673 10.1148/radiol.2343031362 15734925 (Pubitemid 40250807)
20. A.X. Zhu N.S. Holalkere A. Muzikansky 2008 Early antiangiogenic activity of bevacizumab evaluated by computed tomography perfusion scan in patients with advanced hepatocellular carcinoma Oncologist 13 120 125 10.1634/theoncologist. 2007-0174 18305056 (Pubitemid 351342575)
21. F. Kiessling J. Boese C. Corvinus 2004 Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring Eur Radiol 14 1226 1233 15029450
22. D. Gandhi D.B. Chepeha T. Miller 2006 Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ preservation therapy AJNR Am J Neuroradiol 27 101 106 16418366
23. R. Hermans M. Meijerink W. Van den Bogaert 2003 Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head and neck cancer after radiotherapy Int J Radiat Oncol Biol Phys 57 1351 1356 14630273
24. J.P. Delille 2003 Invasive ductal breast carcinoma response to neoadjuvant chemotherapy: noninvasive monitoring with functional MR imaging pilot study Radiology 228 63 69 10.1148/radiol.2281011303 12775851 (Pubitemid 36736070)
25. K.D. Miller C.J. Sweeney G.W. Sledge Jr 2001 Redefining the target: chemotherapeutics as antiangiogenics J Clin Oncol 19 1195 1206 11181686
26. P. Kumar R. Benedict F. Urzua 2005 Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis Lab Invest 85 756 767 10.1038/labinvest.3700272 15864318 (Pubitemid 40799705)
27. B. Lennernas P. Albertsson H. Lennernas 2003 Chemotherapy and antiangiogenesis: drug-specific, dose-related effects Acta Oncol 42 294 303 10.1080/02841860310001835 12899500 (Pubitemid 36851146)
28. S.E. DePrimo C. Bello 2007 Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib Ann Oncol 18 Suppl10 x11 x19 10.1093/annonc/mdm409 17761718
29. L. Hlatky P. Hahnfeldt J. Folkman 2002 Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us J Natl Cancer Inst 94 883 893 12072542
30. R.K. Jain 2002 Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor Semin Oncol 29 [Suppl16] 3 9 12516032
31. F. Bertolini 2008 Chemotherapy and the tumor microenvironment: the contribution of circulating endothelial cells Cancer Metastasis Rev 27 95 101 10.1007/s10555-007-9110-y 18066648
32. H.Q. Xiong R. Herbst S.C. Faria 2004 A phase I surrogate endpoint study of SU6668 in patients with solid tumors Invest New Drugs 22 459 466 10.1023/B:DRUG.0000036688.96453.8d 15292716 (Pubitemid 39619822)
33. M.R. Meijerink H. van Cruijsen K. Hoekman 2007 The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients Eur Radiol 17 1700 1713 10.1007/s00330-006-0425-9 17072618 (Pubitemid 46909659)
34. D.G. McNeel J. Eickhoff F.T. Lee 2005 Phase I trial of a monoclonal antibody specific for integrin (MEDI-522) in patients with advanced malignancies, including an assessment on tumor perfusion Clin Cancer Res 11 7851 7860 10.1158/1078-0432.CCR-05-0262 16278408 (Pubitemid 41611630)
35. A. Sabir R. Schor-Bardach C.J. Wilcox 2008 Perfusion MDCT enables early detection of therapeutic response to antiangiogenic therapy AJR Am J Roentgenol 191 133 139 10.2214/AJR.07.2848 18562736 (Pubitemid 351955217)
36. A. Zima R. Carlos D. Gandhi 2007 Can pretreatment CT perfusion predict response of advanced squamous cell carcinoma of the upper aerodigestive tract treated with induction chemotherapy AJNR Am J Neuroradiol 28 328 334 17297007
37. Z. Rumboldt R. Al-Okaili J.P. Deveikis 2005 Perfusion CT for head and neck tumors: pilot study AJNR Am J Neuroradiol 26 1178 1185 15891181
38. V. Goh S. Halligan J.A. Hugill 2005 Quantitative colorectal cancer perfusion measurement using dynamic contrast-enhanced multidetector-row computed tomography: effect of acquisition time and implications for protocols J Comput Assist Tomogr 29 59 63 10.1097/01.rct.0000152847.00257.d7 15665684 (Pubitemid 40194439)
39. Q.S. Ng V. Goh J. Milner 2007 Acute tumor vascular effects following fractionated radiotherapy in human lung cancer: in vivo whole tumor assessment using volumetric perfusion computed tomography Int J Radiat Oncol Biol Phys 67 417 424 17236965
40. G. Brix M.L. Bahner U. Hoffman 1999 Regional blood flow, capillary permeability, and compartmental volumes: measurement with dynamic CT. Initial experience Radiology 210 269 276 9885619
41. W. Jaschke R.G. Gould P.A. Assimakoloulos 1987 Flow measurements with a high-speed computed tomography scanner Med Phys 14 238 243 10.1118/1.596076 3587146 (Pubitemid 17063690)
42. S. Bisdas M. Baghi A. Smolarz 2007 Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrastenhanced computed tomography studies Invest Radiol 42 172 179 10.1097/01.rli.0000252496.74242.0b 17287647 (Pubitemid 46232822)
43. D. Gandhi E.G. Hoeffner R.C. Carlos 2003 Computed tomography perfusion of squamous cell carcinoma of the upper aerodigestive tract. Initial results J Comput Assist Tomogr 27 687 693 10.1097/00004728-200309000-00005 14501359 (Pubitemid 37087737)
44. M. Zhang M. Kono 1997 Solitary pulmonary nodules: evaluation of blood flow patterns with dynamic CT Radiology 205 471 478 9356631 (Pubitemid 27467328)
45. C.A. Yi K.S. Lee E.A. Kim 2004 Solitary pulmonary nodules: dynamic enhanced multi-detector row CT study and comparison with vascular endothelial growth factor and microvessel density Radiology 233 191 199 10.1148/radiol. 2331031535 15304661 (Pubitemid 39280974)
46. U. Tateishi M. Kusumoto Y. Akiyama 2002 Role of contrast-enhanced dynamic CT in the diagnosis of active tuberculoma Chest 122 1280 1284 10.1378/chest.122.4.1280 12377853 (Pubitemid 35339541)
47. B.J. Moeller Y. Cao C.Y. Li 2004 Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 429 441 10.1016/S1535-6108(04)00115-1 15144951 (Pubitemid 38610245)
48. S. Ando K. Nojima H. Majima 1998 Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line Cancer Lett 132 75 80 10.1016/S0304-3835(98)00160-8 10397456 (Pubitemid 28535187)
49. N. Crokart B.F. Jordan C. Baudelet 2005 Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions Int J Radiat Oncol Biol Phys 63 901 910 16199320
50. R.S. Herbst A. Sandler 2008 Bevacizumab and erlotinib: a promising new approach to the treatment of advanced NSCLC Oncologist 13 1166 1176 10.1634/theoncologist.2008-0108 18997180
51. P.E. Dugdale K.A. Miles 1999 Hepatic metastases: the value of quantitative assessment of contrast enhancement on computed tomography Eur J Radiol 30 206 213 10.1016/S0720-048X(99)00013-3 10452719 (Pubitemid 29343738)
52. K.A. Miles B.B. Kelley 1997 Altered perfusion adjacent to hepatic metastases Clin Radiol 52 162 163 10.1016/S0009-9260(97)80117-1 9043057
53. D.A. Leggett B.B. Kelley I.H. Bunce K.A. Miles 1997 Colorectal cancer: diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols Radiology 205 716 720 9393526
54. K.A. Miles D.A. Leggett B.B. Kelley 1998 In vivo assessment of neovascularization of liver metastases using perfusion CT Br J Radiol 71 276 281 9616236
55. K.A. Miles M.P. Hayball A.K. Dixon 1995 Measurement of human pancreatic perfusion using dynamic computed tomography with perfusion imaging Br J Radiol 68 471 475 10.1259/0007-1285-68-809-471 7788231
56. Y. Tsushima S. Kusano 1998 Age-dependent decline in parenchymal perfusion in the normal human pancreas: measurement by dynamic computed tomography Pancreas 17 148 152 10.1097/00006676-199808000-00006 9700945
57. H. Abe T. Murakami M. Kubota 2005 Quantitative tissue blood flow evaluation of pancreatic tumor: comparison between xenon CT technique and perfusion CT technique based on deconvolution analysis Radiat Med 23 364 370 16342909
58. G.M. Springett S.E. Hoffe 2008 Borderline resettable pancreatic cancer: on the edge of survival Cancer Control 15 295 307 18813197
59. Kubota M (2003) Evaluation between tissue blood flow of pancreatic cancer and therapeutic effect of chemoradiation therapy with Xenon CT. 58th annual meeting. The Japanese Society of Gastroenterological Surgery, Tokyo
60. K.A. Miles M.P. Hayball A.K. Dixon 1994 Functional imaging of changes in human intrarenal perfusion using quantitative dynamic computed tomography Invest Radio 29 911 914 10.1097/00004424-199410000-00008
61. J.H. Wang P.Q. Min P.J. Wang 2006 Dynamic CT evaluation of tumor vascularity in renal cell carcinoma AJR Am J Roentgenol 186 1423 1430 10.2214/AJR.04.1408 16632740 (Pubitemid 46112581)
62. M. Jinzaki A. Tanimoto M. Mukai 2000 Double-phase helical CT of small renal parenchymal neoplasm: correlation with pathologic findings and tumor angiogenesis J Comput Assist Tomogr 24 835 842 10.1097/00004728-200011000-00002 11105696 (Pubitemid 32201804)
63. G.S. Kroog R.J. Motzer 2008 Systemic therapy for metastatic renal cell carcinoma Urol Clin North Am 35 687 701 10.1016/j.ucl.2008.07.007 18992622
64. M. Lamuraglia B. Escudier L. Chami 2006 To predict progression-free survival and overall survival in metastatic renal cancer treated with sorafenib: pilot study using dynamic contrast-enhanced Doppler ultrasound Eur J Cancer 42 2472 2479 10.1016/j.ejca.2006.04.023 16965911 (Pubitemid 44442955)
65. K.T. Flaherty M.A. Rosen D.F. Heitjan 2008 Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma Cancer Biol Ther 7 496 501 18219225
66. M.J. O'Connell 2004 Current status of adjuvant therapy for colorectal cancer Oncology (Williston Park) 18 751 755
67. A.X. Zhu C.G. Willett 2005 Combined modality treatment for rectal cancer Semin Oncol 32 103 112 10.1053/j.seminoncol.2004.09.032 15726512 (Pubitemid 40250132)
68. A. de Vries J. Griebel C. Kremser 2000 Monitoring of tumor microcirculation during fractionated radiation therapy in patients with rectal carcinoma: preliminary results and implications for therapy Radiology 217 385 391 11058632
69. M.L. George A.S. Dzik-Jurasz A.R. Padhani 2001 Non-invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer Br J Surg 88 1628 1636 10.1046/j.0007-1323.2001.01947.x 11736977 (Pubitemid 33124241)
70. S.A. Bigler R.E. Deering M.K. Brawer 1993 Comparison of microscopic vascularity in benign and malignant prostate tissue Human Pathol 24 330 336
71. E. Henderson M.F. Milosevic M.A. Haider I.W. Yeung 2003 Functional CT imaging of prostate cancer Phys Med Biol 48 3085 3100 10.1088/0031-9155/48/18/ 309 14529212 (Pubitemid 37192922)
72. C.R. Jeukens C.A. van den Berg R. Donker 2006 Feasibility and measurements precision of 3D quantitative blood flow mapping of the prostate using dynamic contrast-enhanced multi-slice CT Phys Med Biol 51 4329 4343 10.1088/0031-9155/51/17/013 16912384 (Pubitemid 44261847)
73. M. Fuchsjäger A. Shukla-Dave O. Akin 2008 Prostate cancer imaging Acta Radiol 49 4 10.1080/02841850701545821
74. F.A. van Dorsten M. van der Graaf M.R. Engelbrecht 2004 Combined quantitative dynamic contrast-enhanced MR imaging and (1)H MR spectroscopic imaging of human prostate cancer J Magn Reson Imaging 20 279 287 10.1002/jmri.20113 15269954 (Pubitemid 38970937)
75. A. Fyles M. Milosevic M. Pintilie 2006 Long-term performance of interstitial fluid pressure and hypoxia as prognostic factors in cervix cancer Radiother Oncol 80 132 137 10.1016/j.radonc.2006.07.014 16920212 (Pubitemid 44314013)
76. A. Fyles M. Milosevic D. Hedley 2002 Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer J Clin Oncol 20 680 687 10.1200/JCO.20.3.680 11821448 (Pubitemid 34111374)
77. M.A. Haider M. Milosevic A. Fyles 2005 Assessment of the tumor microenvironment in cervix cancer using dynamic contrast enhanced CT, intersitial fluid pressure and oxygen measurements Int J Radiat Oncol Biol Phys 62 1100 1107 15990015
78. S. Bisdas G.N. Konstantinou P.S. Lee 2007 Dynamic contrast-enhanced CT of head and neck tumors: perfusion measurements using a distributed-parameter tracer kinetic model. Initial results and comparison with deconvolution-based analysis Phys Med Biol 52 6181 6196 10.1088/0031-9155/52/20/007 17921579 (Pubitemid 350093188)
79. G. Petralia L. Preda S. Raimondi 2009 Intra- and interobserver agreement and impact of arterial input selection in perfusion CT measurements performed in squamous cell carcinoma of the upper aerodigestive tract AJNR Am J Neuroradiol 30 1107 1115 10.3174/ajnr.A1540 19342547
80. N. Weidner 1995 Intratumor microvessel density as a prognostic factor in cancer Am J Pathol 147 9 19 7541613
81. M. Preusser H. Heinzl E. Gelpi 2006 Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and Treatment of Cancer Brain Tumor Group Cancer 107 162 170 10.1002/cncr.21973 16721804 (Pubitemid 43939043)
82. S.L. Li D.L. Gao Z.H. Zhao 2007 Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD 105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma World J Gastroenterol 13 6076 6081 10.3748/wjg.13.6076 18023103 (Pubitemid 350238279)
83. C.J. Boos A.D. Blann G.Y. Lip 2007 Assessment of endothelial damage/dysfunction: a focus on circulating endothelial cells Methods Mol Med 139 211 224 10.1007/978-1-59745-571-8-13 18287674