Insight into antigenic diversity of VAR2CSA-DBL5ε domain from multiple Plasmodium falciparum placental isolates

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Gnidehou, Sédami ^a,b   Jessen, Leon ^c   Gangnard, Stéphane ^d   Ermont, Caroline ^a,b   Triqui, Choukri ^a,b   Quiviger, Mickael ^a,b   Guitard, Juliette ^a,b   Lund, Ole ^c   Deloron, Philippe ^a,b   Ndam, Nicaise Tuikue ^a,e  

^a INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d CNRS   (France)

^e Institut des Sciences Biomédicale et Appliqué   (Benin)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; PEPTIDE ANTIBODY; PROTEIN; PROTEOGLYCAN; PROTOZOAL VACCINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VAR2CSA PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY LABELING; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; BLOOD SAMPLING; COMPUTER MODEL; CONTROLLED STUDY; CROSS REACTION; DRUG TARGETING; DUFFY BINDING LIKE 5 EPSILON DOMAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL STUDY; FEMALE; HUMAN; IMMUNE RESPONSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PARITY; PLACENTA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN VARIANT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

MUS; PLASMODIUM FALCIPARUM;

EID: 78049281014     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013105     Document Type: Article

References (41)

1. Duffy PE, Fried M (2003) Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect Immun 71: 6620-6623.
2. Tuikue Ndam NG, Fievet N, Bertin G, Cottrell G, Gaye A, et al. (2004) Variable adhesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates. J Infect Dis 190: 2001-2009.
3. Beeson JG, Rogerson SJ, Cooke BM, Reeder JC, Chai W, et al. (2000) Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria. Nat Med 6: 86-90.
4. Fried M, Duffy PE (1996) Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science 272: 1502-1504.
5. Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE (1998) Maternal antibodies block malaria. Nature 395: 851-852.
6. Salanti A, Dahlback M, Turner L, Nielsen MA, Barfod L, et al. (2004) Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J Exp Med 200: 1197-1203.
7. Tuikue Ndam NG, Salanti A, Le-Hesran JY, Cottrell G, Fievet N, et al. (2006) Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women. J Infect Dis 193: 713-720.
8. Andersen P, Nielsen MA, Resende M, Rask TS, Dahlback M, et al. (2008) Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA. PLoS Pathog 4: e42.
9. Salanti A, Staalsoe T, Lavstsen T, Jensen AT, Sowa MP, et al. (2003) Selective upregulation of a single distinctly structured var gene in chondroitin sulphate Aadhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol Microbiol 49: 179-191.
10. Bengtsson D, Sowa KM, Salanti A, Jensen AT, Joergensen L, et al. (2008) A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes. Malar J 7: 101.
11. Viebig NK, Levin E, Dechavanne S, Rogerson SJ, Gysin J, et al. (2007) Disruption of var2csa gene impairs placental malaria associated adhesion phenotype. PLoS One 2: e910.
12. Avril M GB, Lepolard C, Viaud N, Scherf A, Gysin J (2006) Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies. Microbes Infect 8: 2863-2871.
13. Gamain B, Trimnell AR, Scheidig C, Scherf A, Miller LH, et al. (2005) Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites. J Infect Dis 191: 1010-1013.
14. Resende M, Nielsen MA, Dahlback M, Ditlev SB, Andersen P, et al. (2008) Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA. Malar J 7: 104.
15. Dahlback M, Rask TS, Andersen PH, Nielsen MA, Ndam NT, et al. (2006) Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration. PLoS Pathog 2: e124.
16. Gangnard S, Ndam N, Gnidehou S, Quiviger M, Juillerat A, et al. (2010) Functional and immunological characterization of the var2CSA-DBL5varepsilon domain of a placental Plasmodium falciparum isolate. Mol BiochemParasitol.
17. Trimnell AR, Kraemer SM, Mukherjee S, Phippard DJ, Janes JH, et al. (2006) Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Mol Biochem Parasitol 148: 169-180.
18. Guitard JAP, Ermont C, Gnidehou S, Fievet N, Lund O, et al. (2010) Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal. Malar J 9(1): 165.
19. Nielsen MA (2007) Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin. Experimental Parasitology 117: 1-8.
20. Magistrado P, Salanti A, Tuikue Ndam NG, Mwakalinga SB, Resende M, et al. (2008) VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. J Infect Dis 198: 1071-1074.
21. Barfod L (2007) Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Molecular Microbiology 63(2): 335-347.
22. Sander AF, Salanti A, Lavstsen T, Nielsen MA, Magistrado P, et al. (2009) Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates. PLoS One 4: e6667.
23. Hoof I (2009) Prediction and analysis of MHC class I binding specificities beyond humans. PhD thesis, center for biological Sequence Analysis Department of Systems Biology technical University of Denmark.
24. Steketee RW, Breman JG, Paluku KM, Moore M, Roy J, et al. (1988) Malaria infection in pregnant women in Zaire: the effects and the potential for intervention. Ann Trop Med Parasitol 82: 113-120.
25. Khunrae P, Philip JM, Bull DR, Higgins MK (2009) Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy. J Mol Biol 393: 202-213.
26. Higgins MK (2008) The structure of a chondroitin sulfate-binding domain important in placental malaria. J Biol Chem 283: 21842-21846.
27. Yadouleton AWPG, Asidi A, Moiroux N, Bio-Banganna S, Corbel V, et al. (2010) Insecticide resistance status in Anopheles gambiae in southern Benin. Malar J 9: 83.
28. Briand V, Bottero J, Noel H, Masse V, Cordel H, et al. (2009) Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. J Infect Dis 200: 991-1001.
29. Akogbeto M, Modiano D, Bosman A (1992) Malaria transmission in the lagoon area of Cotonou, Benin. Parassitologia 34: 147-154.
30. Juillerat A, Igonet S, Vigan-Womas I, Guillotte M, Gangnard S, et al. (2010) Biochemical and biophysical characterisation of DBL1alpha1-varO, the rosetting domain of PfEMP1 from the VarO line of Plasmodium falciparum. Mol Biochem Parasitol 170: 84-92.
31. Vigan-Womas I, Guillotte M, Le Scanf C, Igonet S, Petres S, et al. (2008) An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype. Infect Immun 76: 5565-5580.
32. Leblond J, Mignet N, Largeau C, Spanedda MV, Seguin J, et al. (2007) Lipopolythioureas: a new non-cationic system for gene transfer. Bioconjug Chem 18: 484-493.
33. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
34. Flick K (2001) Role of nonimmune IgG bound to PfEMP1 in placental malaria. Science 293: 2098-2100.
35. Resende M, Ditlev SB, Nielsen MA, Bodevin S, Bruun S, et al. (2009) Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites. Int J Parasitol 39: 1195-1204.
36. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, et al. (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23: 2947-2948.
37. Shannon CWW (1949) The mathematical Theory of Communication; Press UoI, editor.
38. Soding J, Biegert A, Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33: W244-248.
39. Delano W (2002) The Pymol Molecular Graphics System.
40. Wallner B, Elofsson A (2003) Can correct protein models be identified? Protein Sci 12: 1073-1086.
41. H2PDB server. Available: http://bio.dfci.harvard.edu/Tools/entropy2pdb.htm.