Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis

Drug Discovery Today: Disease Mechanisms

Volumn 7, Issue 1, 2010, Pages

  Chen, Jeffrey M ^a   Pojer, Florence ^a   Blasco, Benjamin ^a   Cole, Stewart T ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ESCHERICHIA COLI SECRETED PROTEIN A; METALLOPROTEINASE INHIBITOR; NUCLEOSIDE ANALOG; PEPTIDOMIMETIC AGENT; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN ESX 1; PROTEINASE INHIBITOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ESPC; TRANSCRIPTION FACTOR ESPD; TRANSCRIPTION FACTOR ESXA; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

BACTERIAL VIRULENCE; CELL MATURATION; CELL MEMBRANE; CYTOLYSIS; DRUG MECHANISM; GENE LOCUS; GENE SILENCING; GENE TARGETING; HOST RESISTANCE; HUMAN; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOSOME; PROTEIN SECRETION; REPRESSOR GENE; REVIEW;

EID: 78049264734     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2010.09.002     Document Type: Review

References (54)

1. A.K. Barczak, and D.T. Hung Productive steps toward an antimicrobial targeting virulence Curr. Opin. Microbiol. 12 2009 490 496
2. C. Baron Antivirulence drugs to target bacterial secretion systems Curr. Opin. Microbiol. 13 2010 100 105
3. V. Briken Molecular mechanisms of host-pathogen interactions and their potential for the discovery of new drug targets Curr. Drug Targets 9 2008 150 157
4. P.A. DiGiuseppe Champion, and J.S. Cox Protein secretion systems in Mycobacteria Cell. Microbiol. 9 2007 1376 1384
5. A.M. Abdallah Type VII secretion - mycobacteria show the way Nat. Rev. Microbiol. 5 2007 883 891
6. R. Simeone ESX/type VII secretion systems and their role in host-pathogen interaction Curr. Opin. Microbiol. 12 2009 4 10
7. A. Serafini Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc J. Bacteriol. 191 2009 6340 6344
8. M.S. Siegrist Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition Proc. Natl. Acad. Sci. U.S.A. 106 2009 18792 18797
9. A.S. Pym Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis Nat. Med. 9 2003 533 539
10. A. Luthra Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis J. Biol. Chem. 283 2008 36532 36541
11. C.E. Alvarez-Martinez, and P.J. Christie Biological diversity of prokaryotic type IV secretion systems Microbiol. Mol. Biol. Rev. 73 2009 775 808
12. M. Hilleringmann Inhibitors of Helicobacter pylori ATPase Cagalpha block CagA transport and cag virulence Microbiology 152 Pt 10 2006 2919 2930
13. Y.M. Ohol Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence Cell. Host Microbe. 7 2010 210 220
14. J. Xu A unique Mycobacterium ESX-1 protein co-secretes with CFP-10/ESAT-6 and is necessary for inhibiting phagosome maturation Mol. Microbiol. 66 2007 787 800
15. P.A. DiGiuseppe Champion ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria Mol. Microbiol. 73 2009 950 962
16. R.E. Moellering Direct inhibition of the NOTCH transcription factor complex Nature 462 2009 182 188
17. T. Ozawa Designing split reporter proteins for analytical tools Anal. Chim. Acta 556 2006 58 68
18. J.C. Betts Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling Mol. Microbiol. 43 2002 717 731
19. Y. Haile Expression of the mceA, esat-6 and hspX genes in Mycobacterium tuberculosis and their responses to aerobic conditions and to restricted oxygen supply Microbiology 148 Pt 12 2002 3881 3886 (Pubitemid 36097450)
20. B.J. Rogerson Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice Immunology 118 2006 195 201
21. S.M. Fortune Mutually dependent secretion of proteins required for mycobacterial virulence Proc. Natl. Acad. Sci. U.S.A. 102 2005 10676 10681
22. J.A. MacGurn A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis Mol. Microbiol. 57 2005 1653 1663
23. W. Frigui Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP PLoS Pathog. 4 2008 e33
24. A.H. Li Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages PLoS One 5 2010 e11066
25. S. Raghavan Secreted transcription factor controls Mycobacterium tuberculosis virulence Nature 454 2008 717 721
26. N. Willand Synthetic EthR inhibitors boost antituberculous activity of ethionamide Nat. Med. 15 2009 537 544
27. L. Rickman A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor Mol. Microbiol. 56 2005 1274 1286 (Pubitemid 40756010)
28. B.R. Gordon Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis Proc. Natl. Acad. Sci. U.S.A. 107 2010 5154 5159
29. S.C. Derrick, and S.L. Morris The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression Cell. Microbiol. 9 2007 1547 1555
30. N. Ganguly Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence Tuberculosis (Edinb.) 88 2008 510 517
31. T. Hsu The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue Proc. Natl. Acad. Sci. U.S.A. 100 2003 12420 12425
32. T. Kaku RD1 region in mycobacterial genome is involved in the induction of necrosis in infected RAW264 cells via mitochondrial membrane damage and ATP depletion FEMS Microbiol. Lett. 274 2007 189 195
33. A.G. Kinhikar Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells Mol. Microbiol. 75 2010 92 106
34. J.A. MacGurn, and J.S. Cox A genetic screen for Mycobacterium tuberculosis mutants defective for phagosome maturation arrest identifies components of the ESX-1 secretion system Infect. Immun. 75 2007 2668 2678
35. B.B. Mishra Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome Cell. Microbiol. 12 2010 1046 1063
36. S.K. Pathak Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages Nat. Immunol. 8 2007 610 618
37. S.A. Stanley The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis J. Immunol. 178 2007 3143 3152
38. S.A. Stanley Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system Proc. Natl. Acad. Sci. U.S.A. 100 2003 13001 13006
39. H.E. Volkman Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium Science 327 2010 466 469
40. X. Wang ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells J. Immunol. 182 2009 3668 3677
41. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat. Immunol. 11 2010 373 384
42. O. Sperandio Rationalizing the chemical space of protein-protein interaction inhibitors Drug Discov. Today 15 5-6 2009 220 229
43. T. Berg Modulation of protein-protein interactions with small organic molecules Angew. Chem. Int. Ed. Engl. 42 22 2003 2462 2481
44. J.A. Wells, and C.L. McClendon Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 450 7172 2007 1001 1009
45. C. Kuijl Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1 Nature 450 7170 2007 725 730
46. D. Kumar Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis Cell 140 5 2010 731 743
47. A. Haas The phagosome: compartment with a license to kill Traffic 8 4 2007 311 330
48. B.E. Steinberg, and S. Grinstein Assessment of phagosome formation and maturation by fluorescence microscopy Methods Mol. Biol. 412 2007 289 300
49. X. Charpentier Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila PLoS Pathog 5 7 2009 e1000501
50. M.I. de Jonge ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity J. Bacteriol. 189 16 2007 6028 6034
51. N. van der Wel M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells Cell 129 7 2007 1287 1298
52. J.M. Rausch, and W.C. Wimley A high-throughput screen for identifying transmembrane pore-forming peptides Anal. Biochem. 293 2 2001 258 263
53. A. Arnoldo Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen PLoS Genet. 4 2 2008 e1000005
54. M.K. Dahlgren Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia Bioorg. Med. Chem. 18 7 2010 2686 2703