Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 38, 2010, Pages 16625-16630

  Stevenson, William S ^a   Hyland, Craig D ^b   Zhang, Jian Guo ^b   Morgan, Phillip O ^b   Willson, Tracy A ^b   Gill, Anthony ^a   Hilton, Adrienne A ^b   Viney, Elizabeth M ^b   Bahlo, Melanie ^c   Masters, Seth L ^b   Hennebry, Sarah ^d   Richardson, Samantha J ^e   Nicola, Nicos A ^b,f   Metcalf, Donald ^b,f   Hilton, Douglas J ^f,g   Roberts, Andrew W ^b,f   Alexander, Warren S ^b,f  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b Cancer and Haematology Division   (Australia)

^c Bioinformatics Division   (Australia)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e RMIT UNIVERSITY   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

5 hydroxyisourate hydrolase; Hepatocellular carcinoma; N ethyl N nitrosourea mutagenesis; Thrombopoietin; Uric acid

Indexed keywords

5 HYDROXYISOURATE HYDROLASE; CYSTEINE; HYDROLASE; THROMBOPOIETIN; TYROSINE; UNCLASSIFIED DRUG; URATE OXIDASE; URIC ACID; AMIDASE; HYDROXYISOURATE HYDROLASE; MESSENGER RNA; MUTANT PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC SCREENING; HEPATOMEGALY; HOMOZYGOSITY; LIVER CELL CARCINOMA; MALE; MOUSE; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; THROMBOCYTE COUNT; THROMBOCYTOSIS; TUMOR SUPPRESSOR GENE; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; ENZYMOLOGY; FEMALE; GENETICS; LIVER CELL; LIVER NEOPLASMS, EXPERIMENTAL; METABOLISM; MOLECULAR GENETICS; MUTANT MOUSE STRAIN; PHENOTYPE; SEQUENCE HOMOLOGY; TOXICITY; TRANSGENIC MOUSE;

MUS; VERTEBRATA;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANIMALS; FEMALE; GENES, TUMOR SUPPRESSOR; HEPATOCYTES; HEPATOMEGALY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; PHENOTYPE; POINT MUTATION; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; THROMBOCYTOSIS; THROMBOPOIETIN; URATE OXIDASE; URIC ACID;

EID: 78049260516     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010390107     Document Type: Article

References (34)

1. Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (2006) Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nat Chem Biol 2:144-148.
2. Tipton PA (2006) Urate to allantoin, specifically (S)-allantoin. Nat Chem Biol 2:124-125.
3. Wu XW, Lee CC, Muzny DM, Caskey CT (1989) Urate oxidase: Primary structure and evolutionary implications. Proc Natl Acad Sci USA 86:9412-9416.
4. Alderman MH, Cohen H, Madhavan S, Kivlighn S (1999) Serum uric acid and cardiovascular events in successfully treated hypertensive patients. Hypertension 34:144-150.
5. Verdecchia P, et al. (2000) Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension 36:1072-1078.
6. Ames BN, Cathcart R, Schwiers E, Hochstein P (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis. Proc Natl Acad Sci USA 78:6858-6862.
7. Watanabe S, et al. (2002) Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 40:355-360.
8. Broman KW, Wu H, Sen S, Churchill GA (2003) R/qtl: QTL mapping in experimental crosses. Bioinformatics 19:889-890.
9. Eneqvist T, Lundberg E, Nilsson L, Abagyan R, Sauer-Eriksson AE (2003) The transthyretin-related protein family. Eur J Biochem 270:518-532.
10. Hennebry SC (2009) Evolutionary changes to transthyretin: Structure and function of a transthyretin-like ancestral protein. FEBS J 276:5367-5379.
11. Lee Y, et al. (2006) Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction. Mol Cells 22:141-145.
12. Swinkels BW, Gould SJ, Bodnar AG, Rachubinski RA, Subramani S (1991) A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J 10:3255-3262.
13. Hennebry SC, Law RH, Richardson SJ, Buckle AM, Whisstock JC (2006) The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase. J Mol Biol 359:1389-1399.
14. Jung DK, et al. (2006) Structural and functional analysis of PucM, a hydrolase in the ureide pathway and a member of the transthyretin-related protein family. Proc Natl Acad Sci USA 103:9790-9795.
15. Zanotti G, et al. (2006) Structure of zebra fish HIUase: Insights into evolution of an enzyme to a hormone transporter. J Mol Biol 363:1-9.
16. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996) Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87:2162-2170.
17. Hirohashi S, Ishak K, Kojiro M (2000) Hepatocellular carcinoma. Pathology and Genetics of Tumours of the Digestive System, eds Hamilton S, Aaltonen L (International Agency for Research on Cancer, Lyon, France), pp 159-172.
18. Reddy PG, et al. (1988) Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: Liver-specific expression in the rat. Proc Natl Acad Sci USA 85:9081-9085.
19. Usuda N, Reddy MK, Hashimoto T, Rao MS, Reddy JK (1988) Tissue specificity and species differences in the distribution of urate oxidase in peroxisomes. Lab Invest 58:100-111.
20. Kuter DJ (1996) The physiology of platelet production. Stem Cells 14 (Suppl 1):88-101.
21. Griesshammer M, et al. (1999) Aetiology and clinical significance of thrombocytosis: Analysis of 732 patients with an elevated platelet count. J Intern Med 245:295-300.
22. Schafer AI (2004) Thrombocytosis. N Engl J Med 350:1211-1219.
23. Baraf HS, Matsumoto AK, Maroli AN, Waltrip RW, II (2008) Resolution of gouty tophi after twelve weeks of pegloticase treatment. Arthritis Rheum 58:3632-3634.
24. Coiffier B, et al.; Groupe d'Etude des Lymphomes de l'Adulte Trial on Rasburicase Activity in Adult Lymphoma (2003) Efficacy and safety of rasburicase (recombinant urate oxidase) for the prevention and treatment of hyperuricemia during induction chemotherapy of aggressive non-Hodgkin's lymphoma: Results of the GRAAL1 (Groupe d'Etude des Lymphomes de l'Adulte Trial on Rasburicase Activity in Adult Lymphoma) study. J Clin Oncol 21:4402-4406.
25. Goldman SC, et al. (2001) A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood 97:2998-3003.
26. Richette P, Brière C, Hoenen-Clavert V, Loeuille D, Bardin T (2007) Rasburicase for tophaceous gout not treatable with allopurinol: An exploratory study. J Rheumatol 34:2093-2098.
27. Sundy JS, et al.; Pegloticase Phase 2 Study Investigators (2008) Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: Results of a phase II randomized study. Arthritis Rheum 58:2882-2891.
28. Sundy JS, et al. (2007) Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout. Arthritis Rheum 56:1021-1028.
29. Amaro S, et al. (2007) A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke. Stroke 38:2173-2175.
30. Roche A, et al. (2009) Efficacy of rasburicase in hyperuricemia secondary to Lesch-Nyhan syndrome. Am J Kidney Dis 53:677-680.
31. Yue CS, et al. (2008) Population pharmacokinetic and pharmacodynamic analysis of pegloticase in subjects with hyperuricemia and treatment-failure gout. J Clin Pharmacol 48:708-718.
32. Bode VC (1984) Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17. Genetics 108:457-470.
33. Dietrich W, et al. (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131:423-447.
34. Mizushima S, Nagata S (1990) pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res 18:5322.