Bioprocess Development for Large Scale Production of Anticancer Exo-Polysaccharide by Pleurotus ostreatus in Submerged Culture

Journal of Applied Sciences

Volumn 10, Issue 21, 2010, Pages 2523-2529

  El Enshasy, H ^a,b   Daba, A ^b   El Demellawy, M ^b   Ibrahim, A ^b   El Sayed, S ^c   El Badry, I ^b,c  

^a UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

^b Universities and Research centers District   (Egypt)

^c GENETIC ENGINEERING AND BIOTECHNOLOGY RESEARCH INSTITUTE   (Egypt)

Author keywords

Exo polysaccharide; Fed batch; Pleurotus ostreatus; Submerged fermentation

Indexed keywords

BIOCONVERSION; BIOREACTORS; CARBON; CARBON DIOXIDE; SUBSTRATES;

BIOPROCESS DEVELOPMENT; EXOPOLYSACCHARIDES; FED BATCHES; LARGE SCALE PRODUCTIONS; PLEUROTUS OSTREATUS; STIRRED TANK BIOREACTORS; SUBMERGED FERMENTATION; THERAPEUTIC APPLICATION;

BATCH CELL CULTURE;

EID: 78049258897     PISSN: 18125654     EISSN: 18125662     Source Type: Journal    
DOI: 10.3923/jas.2010.2523.2529     Document Type: Article

References (25)

1. Awadh, A.A.N., R.A.A. Mothana, A. Lesnau, H. Pilgrim and U. Lindequist, 2003. Antiviral activity of Inonotus hispidus. Fitotherapia, 74: 483-485.
2. Azuma, S. and Y. Kitamoto, 1994. Nutritional environment for mycelial growth and fruit body formation in Lentinus edodes. Mushroom Sci. Biotechnol., 1: 7-13.
3. Bae, J.T., J. Sinha, J.P. Park, C.H. Song and J.W. Yun, 2000. Optimization of submerged culture conditions for exo-biopolymer production by Paecilomyces japonica. J. Microbiol. Biotechnol., 10: 482-487.
4. Boyle, D., 1998. Nutritional factors limiting the growth of Lentinus edodes and other white-rot fungi in wood. Soil Biol. Biochem., 30: 817-823.
5. Brandt, C.R. and F. Piraino, 2000. Musrhoom antivirals. Recent Res. Dev. Antimicrob. Agents Chemother, 4: 11-26.
6. Chen, RY. and D.Q. Yu, 1993. Studies on the triterpenoid constituents of the spores from Ganoderma lucidum karst. J. Chinese Pharm. Sci., 2: 91-96.
7. Cho, E.J., J.Y. Oh, H.Y. Chang and J.W. Yun, 2006. Production of exopolysaccharides by submerged mycelia culture of a mushroom Tremetta fuciformis. J. Biotechnol., 127: 129-140.
8. Daba, A., M. El-Demellawy and H. El-Enshasy, 2005. Anticancer Activity of Polysaccharides Produced by Pleurotus ostreatus in Submerged Culture. In: Genetic and Cellular Biology of Basidiomycetes, Pisabarro, A.G. and L. Ramirez (Eds.). Pamplona University Press, Spain, pp: 43-55.
9. El-Enshasy, H., 2007. Filamentous Fungal Cultures: Process Characteristics, Products and Applications. In: Bioprocessing for Value-Added Products from Renewable Resources, Yang, S.T. (Ed.). Elsevier Press, New York, pp: 225-261.
10. El-Enshasy, H., K. Hellmuth and U. Rinas, 1999. Fungal morphology in submerged cultures and its relation to glucose oxidase excretion by recombinant Aspergillus niger. Applied Biochem. Biotechnol., 81: 1-11.
11. Lin, Y., P. Lai, Y. Huang and H. Xie, 2004. Immune- competent polysaccharides from the submerged cultured mycelium of culinaiy-medicinal mushroom Lentinus strigellus (Agaricomycetidae). Int. J. Med. Mushrooms, 6: 49-55.
12. Lin, Z.B., 2004. Focus on anti-oxidative and free radical scavenging activity of Ganoderma lucidum. J. Applied Pharmacol., 12: 33-137.
13. Lindequist, U., T.H.J. Niedermeyer and W.D. Julich, 2005. The pharmacological potential of mushrooms. Evid. based Complement. Aleternat. Med., 2: 285-299.
14. Maier, U. and J. Biichs, 2001. Characterisation of the gas-liquidmass transfer in shaking bioreactors. J. Biochem. Eng., 7: 99-106.
15. Mizuno, T., 1999. The extraction and development of antitumore-active poly-saccahrides from medicinal mushrooms in Japan. Int. J. Med. Mushrooms, 1: 9-30.
16. Morais, M.H., A.C. Ramos, N. Matos and E.J. Santos- Oliveira, 2000. Note: Production of shiitake mushroom (Lentinus edodes) on ligninocellulosic residues. Food Sci. Technol. Int., 6: 123-128.
17. Mothana, R.A.A., R. Jansen, W.D. Julich and U. Lindequist, 2000. Ganomycin A. and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi. J. Nat. Prod., 63: 416-418.
18. Rajarathnam, S., M.N. Shashireka and Z. Bano, 1992. Biopotentialities of basidiomycetes. Adv. Applied Microbiol., 37: 233-361.
19. Sanchez, C., 2004. Modern aspects of mushroom culture technology. Applied Microbiol. Biotechnol., 64: 756-762.
20. Smania, A., F.D. Monache, E.F.A. Smania and R.S. Cuneo, 1999. Antibacterial activity of steroidal compounds isolated from Ganoderma applanatum Pat. (Aphyllophoromycetidea) fruit body. Int. J. Med. Mushrooms, 5: 31-35.
21. Smania, E.F.A., F.D. Monache, A. Smania and Y.R.A. Cuneo, 2003. Antifungal activity of sterols an triperpenes isolated from Ganoderma annulare. Fitoterapia, 74: 375-377.
22. Wang, J.C., S.H. Ju, Z.C. Liang and C.J. Yeh, 2005. Optimization of the production of water-soluble polysaccharide from Pleurotus citrinopileatus in submerged culture and its antitumor effect. Applied Microbiol. Biotechnol., 67: 759-766.
23. Wasser, S.P., K.K. Tan and V.I. Elisashvili, 2002. Hypoglycemic, inter feronogenous and immunomodulatory acticity of Tremellastin from the submerged culture of Tremella mesenterica etz. Fr. (Heterobasidiomycetes). Int. J. Med. Mushrooms, 4: 215-227.
24. Yang, F.C. and C.B. Liau, 1998. The influence of environmental conditions on polysaccharide formation by Ganoderma lucidum in submerged cultures. Process Biochem., 33: 547-553.
25. Zhang, Y., G. Millis and M.G. Nair, 2002. Cyclooxygenase inhibitoiy and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J. Agnc. FoodChem., 50: 7581-7585.