Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: Randomized controlled trial

CMAJ. Canadian Medical Association Journal

Volumn 182, Issue 15, 2010, Pages 1624-1630

  Bruggink, Sjoerd C ^a   Gussekloo, Jacobijn ^a   Berger, Marjolein Y ^b   Zaaijer, Krista ^a   Assendelft, Willem J J ^a   De Waal, Margot W M ^a   Bouwes Bavinck, Jan Nico ^a   Koes, Bart W ^b   Eekhof, Just A H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LIQUID NITROGEN; SALICYLIC ACID; KERATOLYTIC AGENT; NITROGEN;

ARTICLE; BLISTER; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; CRYOTHERAPY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN; PATIENT COMPLIANCE; PATIENT SATISFACTION; PRIMARY MEDICAL CARE; SCAR FORMATION; SKIN IRRITATION; TREATMENT OUTCOME; VERRUCA PLANTARIS; VERRUCA VULGARIS; ADOLESCENT; COMPARATIVE STUDY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; WARTS;

ADMINISTRATION, TOPICAL; ADOLESCENT; CHILD; CHILD, PRESCHOOL; CRYOTHERAPY; FEMALE; HUMANS; KERATOLYTIC AGENTS; MALE; NITROGEN; SALICYLIC ACID; TREATMENT OUTCOME; WARTS;

EID: 78049251309     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.092194     Document Type: Article

References (26)

1. Rea JN, Newhouse ML, Halil T. Skin disease in Lambeth. A community study of prevalence and use of medical care. Br J Prev Soc Med 1976;30:107-14.
2. Johnson MT, Roberts J. Skin conditions and related need for medical care among persons 1-74 years. United States, 1971-1974. Vital Health Stat 1978;i-72.
3. Beliaeva TL. The population incidence of warts [article in Russian]. Vestn Dermatol Venerol 1990;2:55-8.
4. van Haalen FM, Bruggink SC, Gussekloo J, et al. Warts in primary school children: Prevalence and relation with environmental factors. Br J Dermatol 2009; 161: 148-52.
5. Massing AM, Epstein WL. Natural history of warts. A two-year study. Arch Dermatol 1963;87:306-10.
6. Dudley W. The psychological impact of warts on patients' lives. Prof Nurse 1995;11:99-100.
7. Westert GP, Schellevis FG, de Bakker DH, et al. Monitoring health inequalities through general practice: the Second Dutch National Survey of General Practice. Eur J Public Health 2005;15:59-65.
8. Office of Population Censuses and Surveys. Morbidity statistics from general practice, fourth national study 1991-1992 [series MB5 no. 3]. London (UK): The Office; 1995. Available: www.statistics.gov.uk /downloads/theme- health/MB5No3.pdf (accessed 2010 Aug. 18).
9. Bruggink SC, Waagmeester SC, Gussekloo J, et al. Current choices in treatment of cutaneous warts: a survey among Dutch general practitioners. Fam Pract 2010; July 7 [Epub ahead of print].
10. Gibbs S, Harvey I. Topical treatments for cutaneous warts [review]. Cochrane Database Syst Rev 2006;(3):CD001781.
11. Thomas KS, Keogh-Brown MR, Chalmers JR, et al. Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts. An economic decision model. Health Technol Assess 2006;10:iii, ix-87.
12. Androphy EJ, Lowy DR. Warts. In: Wolff K, Goldsmith LA, Katz SI, et al., editors. Fitzpatrick's dermatology in general medicine. 7th ed. New York (NY): McGraw-Hill; 2008. p. 1914-23.
13. Hansen JG, Schmidt H. Plantar warts. Occurrence and cryosurgical treatment [article in Danish]. Ugeskr Laeger 1986;148:173-4.
14. Sonnex TS, Camp RDR. The treatment of recalcitrant viral warts with high dose cryosurgery under local anaeshesia. Br J Dermatol 1988;119:38-9.
15. Berth-Jones J, Bourke J, Eglitis H, et al. Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol 1994;131:883-6.
16. Connolly M, Bazmi K, O'Connell M, et al. Cryotherapy of viral warts: a sustained 10-s freeze is more effective than the traditional method. Br J Dermatol 2001; 145: 554-7.
17. Wilson P. Immunotherapy v cryotherapy for hand warts; a controlled trial [abstract]. Scott Med J 1983;28:191.
18. Gibson JR, Harvey SG, Barth J, et al. A comparison of acyclovir cream versus placebo cream versus liquid nitrogen in the treatment of viral plantar warts. Dermatologica 1984;168:178-81.
19. Bunney MH, Hunter JA, Ogilvie MM, et al. The treatment of plantar warts in the home. A critical appraisal of a new preparation. Practitioner 1971;207:197-204.
20. Flindt-Hansen H, Tikjob G, Brandrup F. Wart treatment with anthralin. Acta Derm Venereol 1984;64:177-9.
21. Auken G, Gade M, Pilgaard CE. Treatment of warts of the hands and feet with Verucid [article in Danish]. Ugeskr Laeger 1975;137:3036-8.
22. Bart BJ, Biglow J, Vance JC, et al. Salicylic acid in karaya gum patch as a treatment for verruca vulgaris. J Am Acad Dermatol 1989;20:74-6.
23. Spanos NP, Williams V, Gwynn MI. Effects of hypnotic, placebo, and salicylic acid treatments on wart regression. Psychosom Med 1990;52:109-14.
24. Bunney MH, Nolan MW, Williams DA. An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. Br J Dermatol 1976;94:667-79.
25. Steele K, Irwin WG. Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice. J R Coll Gen Pract 1988;38:256-8.
26. Jablonska S, Majewski S, Obalek S, et al. Cutaneous warts. Clin Dermatol 1997;15:309-19.