Could proton pump inhibitors cause cancer?

Archives of Internal Medicine

Volumn 170, Issue 19, 2010, Pages 1775-1776

  Rosch, Paul J ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b American Institute of Stress   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ESOMEPRAZOLE; HYDROCHLORIC ACID; PANCREAS ENZYME; PREDNISOLONE; PROTON PUMP INHIBITOR; MAGNESIUM;

CANCER RISK; CARCINOGENESIS; DRUG EFFECT; DYSPLASIA; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS MUCOSA; GASTROESOPHAGEAL REFLUX; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INFLAMMATORY CELL; LETTER; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BLOOD; CHEMICALLY INDUCED; COMPLICATION; MAGNESIUM DEFICIENCY; NEOPLASMS; RISK FACTOR;

ANIMALS; HUMANS; MAGNESIUM; MAGNESIUM DEFICIENCY; NEOPLASMS; PROTON PUMP INHIBITORS; RISK FACTORS;

EID: 78049232789     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.375     Document Type: Letter

References (5)

1. Katz MH. Failing the acid test: benefits of proton pump inhibitors may not justify the risks for many users. Arch Intern Med. 2010;170(9):747-748.
2. Lepage C, Rachet B, Jooste V, Faivre J, Coleman MP. Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol. 2008;103(11):2694-2699.
3. Poulsen AH, Christensen S, McLaughlin JK, et al. Proton pump inhibitors and risk of gastric cancer: a population-based cohort study. Br J Cancer. 2009;100(9):1503-1507.
4. Souza RF, Huo X, Mittal V, et al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology. 2009;137(5):1776-1784.
5. Zhang DH, Zhou LY, Dong XY, Cui RL, Xue Y, Lin SR. Factors influencing intercellular spaces in the rat esophageal epithelium. World J Gastroenterol. 2010;16(9):1063-1069.