Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus

Cancer Research

Volumn 70, Issue 20, 2010, Pages 8015-8024

  Easwaran, Hariharan P ^a   Van Neste, Leander ^b   Cope, Leslie ^a   Sen, Subhojit ^a   Mohammad, Helai P ^a   Pageau, Gayle J ^c   Lawrence, Jeanne B ^c   Herman, James G ^a   Schuebel, Kornel E ^d   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMATIN; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INCIDENCE; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE, TUMOR; CELL NUCLEUS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IN SITU HYBRIDIZATION; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERCELLULAR ADHESION MOLECULE-1; MICROSATELLITE REPEATS; NEOPLASMS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78049232764     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0765     Document Type: Article

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