Nuclear emancipation: A platelet tour de force

Science Signaling

Volumn 3, Issue 144, 2010, Pages

  Spinelli, Sherry L ^a   Maggirwar, Sanjay B ^a   Blumberg, Neil ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

BLOOD CLOTTING; ENZYME ACTIVITY; HEMOSTASIS; HUMAN; IMMUNITY; INFLAMMATION; MEGAKARYOCYTE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOSIS; TUMOR GROWTH; ANIMAL; METABOLISM; PHYSIOLOGY;

MAMMALIA;

ANIMALS; BLOOD PLATELETS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEMOSTASIS; HUMANS; MEGAKARYOCYTES; NF-KAPPA B; PLATELET ACTIVATION;

EID: 77958564366     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3144pe37     Document Type: Review

References (34)

1. J. E. Italiano Jr., R. A. Shivdasani, Megakaryocytes and beyond: The birth of platelets. J. Thromb. Haemost. 1, 1174-1182 (2003).
2. D. V. Gnatenko, J. J. Dunn, S. R. McCorkle, D. Weissmann, P. L. Perrotta, W. F. Bahou, Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 101, 2285-2293 (2003).
3. M. M. Denis, N. D. Tolley, M. Bunting, H. Schwertz, H. Jiang, S. Lindemann, C. C.Yost, F. J. Rubner, K. H. Albertine, K. J. Swoboda, C. M. Fratto, E. Tolley, L. W. Kraiss, T. M. McIntyre, G. A. Zimmerman, A. S.Weyrich, Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122, 379-391 (2005).
4. M. Camera, M. Frigerio, V. Toschi, M. Brambilla, F. Rossi, D. C. Cottell, P. Maderna, A. Parolari, R. Bonzi, O. De Vincenti, E. Tremoli, Platelet activation induces cell-surface immunoreactive tissue factor expression, which is modulated differently by antiplatelet drugs. Arterioscler. Thromb. Vasc. Biol. 23, 1690-1696 (2003).
5. A. S.Weyrich, D. A. Dixon, R. Pabla, M. R. Elstad, T. M. McIntyre, S. M. Prescott, G. A. Zimmerman, Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc. Natl. Acad. Sci. U.S.A. 95, 5556-5561 (1998).
6. P. Landry, I. Plante, D. L. Ouellet, M. P. Perron, G. Rousseau, P. Provost, Existence of a microRNA pathway in anucleate platelets. Nat. Struct. Mol. Biol. 16, 961-966 (2009).
7. J. P. McRedmond, S. D. Park, D. F. Reilly, J. A. Coppinger, P. B. Maguire, D. C. Shields, D. J. Fitzgerald, Integration of proteomics and genomics in platelets: A profile of platelet proteins and platelet-specific genes. Mol. Cell. Proteomics 3, 133-144 (2004).
8. D. L. Springer, J. H. Miller, S. L. Spinelli, L. Pasa-Tolic, S. O. Purvine, D. S. Daly, R. C. Zangar, S. Jin, N. Blumberg, C. W. Francis, M. B. Taubman, A. E. Casey, S. D. Wittlin, R. P. Phipps, Platelet proteome changes associated with diabetes and during platelet storage for transfusion. J. Proteome Res. 8, 2261-2272 (2009).
9. F. Akbiyik, D. M. Ray, K. F. Gettings, N. Blumberg, C. W. Francis, R. P. Phipps, Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood 104, 1361-1368 (2004).
10. F.Y. Ali, S. J. Davidson, L. A. Moraes, S. L. Traves, M. Paul-Clark, D. Bishop-Bailey, T. D. Warner, J. A. Mitchell, Role of nuclear receptor signaling in platelets: Antithrombotic effects of PPARbeta. FASEB J. 20, 326-328 (2006).
11. L. A. Moraes, K. E. Swales, J. A. Wray, A. Damazo, J. M. Gibbins, T. D. Warner, D. Bishop-Bailey, Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets. Blood 109, 3741-3744 (2007).
12. D. M. Ray, S. L. Spinelli, S. J. Pollock, T. I. Murant, J. J. O'Brien, N. Blumberg, C. W. Francis, M. B. Taubman, R. P. Phipps, Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb. Haemost. 99, 86-95 (2008).
13. L. Dhawan, B. Liu, B. C. Blaxall, M. B. Taubman, A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J. Biol. Chem. 282, 10146-10152 (2007).
14. S. Gambaryan, A. Kobsar, N. Rukoyatkina, S. Her terich, J. Geiger, A. Smolenski, S. M. Lohmann, U. Walter, Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J. Biol. Chem. 285, 18352-18363 (2010).
15. H. S. Lee, S. D. Kim, W. M. Lee, M. Endale, S. M. Kamruzzaman, W. J. Oh, J. Y. Cho, S. K. Kim, H. J. Cho, H. J. Park, M. H. Rhee, A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. Eur. J. Pharmacol. 627, 85-91 (2010).
16. F. Liu, S. Morris, J. Epps, R. Carroll, Demonstration of an activation regulated NF-kappaB/ I-kappaBalpha complex in human platelets. Thromb. Res. 106, 199-203 (2002).
17. E. Malaver, M. A. Romaniuk, L. P. D'Atri, R. G. Pozner, S. Negrotto, R. Benzadón, M. Schattner, NF-kappaB inhibitors impair platelet activation responses. J. Thromb. Haemost. 7, 1333-1343 (2009).
18. S. L. Spinelli, A. E. Casey, S. J. Pollock, J. M. Gertz, D. H. McMillan, S. D. Narasipura, N. A. Mody, M. R. King, S. B. Maggirwar, C.W. Francis, M. B. Taubman, N. Blumberg, R. P. Phipps, Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler. Thromb. Vasc. Biol. 30, 591-598 (2010).
19. T. D. Gilmore, Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene 25, 6680-6684 (2006).
20. D. Kelly, J. I. Campbell, T. P. King, G. Grant, E. A. Jansson, A. G. Coutts, S. Pettersson, S. Conway, Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 5, 104-112 (2003).
21. J. Profirovic, M. Gorovoy, J. Niu, S. Pavlovic, T. Voyno-Yasenetskaya, A novel mechanism of G protein-dependent phosphorylation of vasodilator- stimulated phosphoprotein. J. Biol. Chem. 280, 32866-32876 (2005).
22. H. Zhong, H. SuYang, H. Erdjument-Bromage, P. Tempst, S. Ghosh, The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89, 413-424 (1997).
23. J. E. Bear, J. J. Loureiro, I. Libova, R. Fässler, J. Wehland, F. B. Gertler, Negative regulation of fibroblast motility by Ena/VASP proteins. Cell 101, 717-728 (2000).
24. R. Perona, S. Montaner, L. Saniger, I. Sánchez-Pérez, R. Bravo, J. C. Lacal, Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11, 463-475 (1997).
25. H. Ohno, G. Takimoto, T. W. McKeithan, The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60, 991-997 (1990).
26. A. S. Weyrich, M. M. Denis, H. Schwertz, N. D. Tolley, J. Foulks, E. Spencer, L. W. Kraiss, K. H. Albertine, T. M. McIntyre, G. A. Zimmerman, mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 109, 1975-1983 (2007).
27. A. Chariot, The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol. 19, 404-413 (2009).
28. A. Criollo, L. Senovilla, H. Authier, M. C. Maiuri, E. Morselli, I. Vitale, O. Kepp, E. Tasdemir, L. Galluzzi, S. Shen, M. Tailler, N. Delahaye, A. Tesniere, D. De Stefano, A. B. Younes, F. Harper, G. Pierron, S. Lavandero, L. Zitvogel, A. Israel, V. Baud, G. Kroemer, The IKK complex contributes to the induction of autophagy. EMBO J. 29, 619-631 (2010).
29. K. Bettermann, M. Vucur, J. Haybaeck, C. Koppe, J. Janssen, F. Heymann, A. Weber, R. Weiskirchen, C. Liedtke, N. Gassler, M. Müller, R. de Vos, M. J. Wolf, Y. Boege, G. M. Seleznik, N. Zeller, D. Erny, T. Fuchs, S. Zoller, S. Cairo, M. A. Buendia, M. Prinz, S. Akira, F. Tacke, M. Heikenwalder, C. Trautwein, T. Luedde, TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 17, 481-496 (2010).
30. V. Bottero, F. Rossi, M. Samson, M. Mari, P. Hofman, J. F. Peyron, Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator. J. Biol. Chem. 276, 21317-21324 (2001).
31. P. C. Cogswell, D. F. Kashatus, J. A. Keifer, D. C. Guttridge, J. Y. Reuther, C. Bristow, S. Roy, D. W. Nicholson, A. S. Baldwin, Jr., NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J. Biol. Chem. 278, 2963-2968 (2003).
32. L. A. Moraes, M. Spyridon, W. J. Kaiser, C. I. Jones, T. Sage, R. E. Atherton, J. M. Gibbins, Non-genomic effects of PPARgamma ligands: Inhibition of GPVI-stimulated platelet activation. J. Thromb. Haemost. 8, 577-587 (2010).
33. J. W. Thornton, E. Need, D. Crews, Resurrecting the ancestral steroid receptor: Ancient origin of estrogen signaling. Science 301, 1714-1717 (2003).
34. Funding: RC1 HL100051, 1R01 HL095467, ES01247, and NS054578. Competing interests: N.B. has served as a paid consultant to Fenwal, Pall Biomedical, and Caridian, and N.B. and R.P.P. have patents pending related to the use of PPARγ and/or RXR agonists to inhibit platelet functions.