Proteomics and Down syndrome screening: A validation study

Prenatal Diagnosis

Volumn 30, Issue 11, 2010, Pages 1039-1043

  Koster, M P H ^a   Pennings, J L A ^a   Imholz, S ^a   Rodenburg, W ^a   Visser, G H A ^b   De Vries, A ^a   Schielen, P C J I ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bead based multiplexed assays; Biomarkers; Down syndrome; Epidermal growth factor (EGF); First trimester serum screening

Indexed keywords

ALPHA FETOPROTEIN; BINDING PROTEIN; BIOLOGICAL MARKER; CHORIONIC GONADOTROPIN BETA SUBUNIT; EOTAXIN; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR RAGE BINDING PROTEIN; HAPTOGLOBIN; INSULIN; LIPOPROTEIN A; PREGNANCY ASSOCIATED PLASMA PROTEIN A; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DOWN SYNDROME; FEMALE; GESTATIONAL AGE; HUMAN; IMMUNOASSAY; MATERNAL AGE; MATERNAL SERUM; NUCHAL TRANSLUCENCY MEASUREMENT; PREGNANCY; PRIORITY JOURNAL; PROTEOMICS;

ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DOWN SYNDROME; FEMALE; HUMANS; INFANT, NEWBORN; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PRENATAL DIAGNOSIS; PROTEOMICS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 77958560089     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2606     Document Type: Article

References (18)

1. Brambati B, Simoni G, Bonacchi I, Piceni L. 1986. Fetal chromosomal aneuploidies and maternal serum alpha-fetoprotein levels in first trimester. Lancet 2: 165-166.
2. Busch A, Michel S, Hoppe C, Driesch D, Claussen U, von Eggeling F. 2005. Proteome analysis of maternal serum samples for trisomy 21 pregnancies using ProteinChip arrays and bioinformatics. J Histochem Cytochem 53: 341-343.
3. Cuckle H, Benn P, Wright D. 2005. Down syndrome screening in the first and/or second trimester: model predicted performance using meta-analysis parameters. Semin Perinatol 29: 252-257.
4. Frendo JL, Vidaud M, Guibourdenche J, et al. 2000. Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome. J Clin Endocrinol Metab 85: 3700-3777.
5. Garcia-Lloret MI, Yui J, Winkler-Lowen B, Guilbert LJ. 1996. Epidermal growth factor inhibits cytokine-induced apoptosis of primary human trophoblasts. J Cell Physiol 167: 324-332.
6. Kolialexi A, Tsangaris GT, Papantoniou N, et al. 2008. Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma. Prenat Diagn 28: 691-698.
7. Koster MP, Pennings JL, Imholz S, et al. 2009. Bead-based multiplexed immunoassays to identify new biomarkers in maternal serum to improve first trimester Down syndrome screening. Prenat Diagn 29: 857-862.
8. Moll SJ, Jones CJ, Crocker IP, Baker PN, Heazell AE. 2007. Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species. Apoptosis 12: 1611-1622.
9. Morrish DW, Bhardwaj D, Dabbagh LK, Marusyk H, Siy O. 1987. Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta. J Clin Endocrinol Metab 65: 1282-1290.
10. Nagalla SR, Canick JA, Jacob T, et al. 2007. Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers. J Proteome Res 6: 1245-1257.
11. Pidoux G, Guibourdenche J, Frendo JL, et al. 2004. Impact of trisomy 21 on human trophoblast behaviour and hormonal function. Placenta 25(Suppl A): S79-S84.
12. Ransohoff DF. 2004. Rules of evidence for cancer molecular-marker discovery and validation. Nat Rev Cancer 4: 309-314.
13. Schielen PC, Van Leeuwen-Spruijt M, Belmouden I, Elvers LH, Jonker M, Loeber JG. 2006. Multi-centre first-trimester screening for Down syndrome in the Netherlands in routine clinical practice. Prenat Diagn 26: 711-718.
14. Spencer K, Berry E, Crossley JA, Aitken DA, Nicolaides KH. 2000. Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy? Prenat Diagn 20: 311-317.
15. Tsangaris GT, Karamessinis P, Kolialexi A, et al. 2006. Proteomic analysis of amniotic fluid in pregnancies with Down syndrome. Proteomics 6: 4410-4419.
16. Wortelboer EJ, Koster MP, Stoutenbeek P, et al. 2009. First-trimester Down syndrome screening performance in the Dutch population; how to achieve further improvement? Prenat Diagn 29: 588-592.
17. Ye X, Blonder J, Veenstra TD. 2009. Targeted proteomics for validation of biomarkers in clinical samples. Brief Funct Genomic Proteomic 8: 126-135.
18. Zolg W. 2006. The proteomic search for diagnostic biomarkers: lost in translation? Mol Cell Proteomics 5: 1720-1726.