Td92, an outer membrane protein of Treponema denticola, induces osteoclastogenesis via prostaglandin-E2-mediated RANKL/osteoprotegerin regulation

Journal of Periodontal Research

Volumn 45, Issue 6, 2010, Pages 772-779

  Kim, M ^a,b   Jun, H K ^c   Choi, B K ^c   Cha, J H ^a,b   Yoo, Y J ^a,b  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Osteoclast formation; Periodontitis; Td92; Treponema denticola

Indexed keywords

ADHESIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROSTAGLANDIN E2; RECOMBINANT PROTEIN;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BIOSYNTHESIS; BONE MARROW CELL; CELL CULTURE; CHEMISTRY; COCULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; MOUSE; MOUSE STRAIN; OSTEOBLAST; OSTEOCLAST; PHYSIOLOGY; TREPONEMA DENTICOLA;

ADHESINS, BACTERIAL; ALVEOLAR BONE LOSS; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; COCULTURE TECHNIQUES; DINOPROSTONE; GENE EXPRESSION REGULATION; MICE; MICE, INBRED STRAINS; OSTEOBLASTS; OSTEOCLASTS; OSTEOPROTEGERIN; RANK LIGAND; RECOMBINANT PROTEINS; TREPONEMA DENTICOLA;

EID: 77958527926     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01298.x     Document Type: Article

References (39)

1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345-357.
2. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000;15:2-12.
3. Nagasawa T, Kiji M, Yashiro R et al. Roles of receptor activator of nuclear factor-ΚB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000 2007;43:65-84.
4. Hofbauer LC, Kuhne CA, Viereck V. The OPG/RANKL/RANK system in metabolic bone diseases. J Musculoskelet Neuronal Interact 2004;4:268-275.
5. Chung YH, Chang EJ, Kim SJ et al. Lipopolysaccharide from Prevotella nigrescens stimulates osteoclastogenesis in cocultures of bone marrow mononuclear cells and primary osteoblasts. J Periodontal Res 2006;41:288-296.
6. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005;38:135-187.
7. Miyata Y, Takeda H, Kitano S, Hanazawa S. Porphyromonas gingivalis lipopolysaccharide-stimulated bone resorption via CD14 is inhibited by broad-spectrum antibiotics. Infect Immun 1997;65:3513-3519.
8. Reddi D, Bostanci N, Hashim A et al. Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells. Microbes Infect 2008;10:1459-1468.
9. Nishihara T, Ueda N, Amano K et al. Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1α production in mouse marrow cultures. Infect Immun 1995;63:1893-1898.
10. Kirby AC, Meghji S, Nair SP et al. The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL. J Clin Invest 1995;96:1185-1194.
11. Kikuchi T, Matsuguchi T, Tsuboi N et al. Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 2001;166:3574-3579.
12. Rogers JE, Li F, Coatney DD et al. Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis. J Periodontol 2007;78:550-558.
13. Ueda N, Nishihara T, Ishihara Y, Amano K, Kuroyanagi T, Noguchi T. Role of prostaglandin in the formation of osteoclasts induced by capsular-like polysaccharide antigen of Actinobacillus actinomycetemcomitans strain Y4. Oral Microbiol Immunol 1995;10:69-75.
14. Sela MN. Role of Treponema denticola in periodontal diseases. Crit Rev Oral Biol Med 2001;12:399-413.
15. Uitto VJ, Grenier D, Chan EC, McBride BC. Isolation of a chymotrypsinlike enzyme from Treponema denticola. Infect Immun 1988;56:2717-2722.
16. Rosen G, Naor R, Kutner S, Sela MN. Characterization of fibrinolytic activities of Treponema denticola. Infect Immun 1994;62:1749-1754.
17. Rosen G, Naor R, Rahamim E, Yishai R, Sela MN. Proteases of Treponema denticola outer sheath and extracellular vesicles. Infect Immun 1995;63:3973-3979.
18. Cameron CE, Lukehart SA, Castro C, Molini B, Godornes C, Van Voorhis WC. Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. J Infect Dis 2000;181:1401-1413.
19. Jun HK, Kang YM, Lee HR, Lee SH, Choi BK. Highly conserved surface proteins of oral spirochetes as adhesins and potent inducers of proinflammatory and osteoclastogenic factors. Infect Immun 2008;76:2428-2438.
20. Wyss C, Choi BK, Schupbach P, Moter A, Guggenheim B, Göbel UB. Treponema lecithinolyticum sp. nov., a small saccharolytic spirochaete with phospholipase A and C activities associated with periodontal diseases. Int J Syst Bacteriol 1999;49(pt 4):1329-1339.
21. Choi HG, Kim JM, Kim BJ, Yoo YJ, Cha JH. Mouse strain-dependent osteoclastogenesis in response to lipopolysaccharide. J Microbiol 2007;45:566-571.
22. 3 in osteoclast differentiation and function. Methods Enzymol 1997;282:223-235.
23. Cullen PA, Haake DA, Adler B. Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev 2004;28:291-318.
24. Egli C, Leung WK, Muller KH, Hancock RE, McBride BC. Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola. Infect Immun 1993;61:1694-1699.
25. Fenno JC, Hannam PM, Leung WK, Tamura M, Uitto VJ, McBride BC. Cytopathic effects of the major surface protein and the chymotrypsinlike protease of Treponema denticola. Infect Immun 1998;66:1869-1877.
26. Fenno JC, Tamura M, Hannam PM, Wong GW, Chan RA, McBride BC. Identification of a Treponema denticola OppA homologue that binds host proteins present in the subgingival environment. Infect Immun 2000;68:1884-1892.
27. 2 is crucially involved in lipopolysaccharide-induced osteoclast formation. J Immunol 2004;172:2504-2510.
28. Uitto VJ, Pan YM, Leung WK et al. Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells. Infect Immun 1995;63:3401-3410.
29. Lux R, Miller JN, Park NH, Shi W. Motility and chemotaxis in tissue penetration of oral epithelial cell layers by Treponema denticola. Infect Immun 2001;69:6276-6283.
30. Grenier D, Uitto VJ, McBride BC. Cellular location of a Treponema denticola chymotrypsinlike protease and importance of the protease in migration through the basement membrane. Infect Immun 1990;58:347-351.
31. Caimano MJ, Bourell KW, Bannister TD, Cox DL, Radolf JD. The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure. Infect Immun 1999;67:4072-4083.
32. Okahashi N, Inaba H, Nakagawa I et al. Porphyromonas gingivalis induces receptor activator of NF-κB ligand expression in osteoblasts through the activator protein 1 pathway. Infect Immun 2004;72:1706-1714.
33. Mogi M, Otogoto J, Ota N, Togari A. Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis. J Dent Res 2004;83:166-169.
34. Vernal R, Chaparro A, Graumann R, Puente J, Valenzuela MA, Gamonal J. Levels of cytokine receptor activator of nuclear factor κB ligand in gingival crevicular fluid in untreated chronic periodontitis patients. J Periodontol 2004;75:1586-1591.
35. Offenbacher S, Odle BM, Gray RC, Van Dyke TE. Crevicular fluid prostaglandin E levels as a measure of the periodontal disease status of adult and juvenile periodontitis patients. J Periodontal Res 1984;19:1-13.
36. 2 levels as a predictor of periodontal attachment loss. J Periodontal Res 1986;21:101-112.
37. 2 secretion as a determinant of periodontal disease expression. J Periodontol 1993;64:432-444.
38. Suzawa T, Miyaura C, Inada M et al. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 2000;141:1554-1559.
39. 2 in infected murine osteoblasts. Infect Immun 2008;76:5120-5126.