Intestinal absorption properties of flavones and extract of Fructus Aurantii Immaturus in rats

Zhongguo Zhongyao Zazhi

Volumn 35, Issue 14, 2010, Pages 1850-1854

  Xin, Ran ^a,b   Chen, Yen ^a,b   Jia, Xiaobin ^a   Tan, Xiaobin ^a   Wang, Jinyan ^a,b  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^b JIANGSU UNIVERSITY   (China)

Author keywords

Absorption; Apparent oil water partition coefficient; Extract; Flavonoids; Fructus Aurantii Immaturus; Intestinal enzymes; Rat intestinal perfusion

Indexed keywords

AURANTIIN; BUFFER; DRUG METABOLITE; ENZYME; HESPERIDIN; NEOHESPERIDIN; OCTANOL; SOUR ORANGE EXTRACT; WATER; FLAVONE DERIVATIVE; PLANT EXTRACT;

ANIMAL TISSUE; ARTICLE; AURANTII IMMATURUS; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG PENETRATION; FRUIT; INTESTINE ABSORPTION; INTESTINE PERFUSION; MEDICINAL PLANT; NONHUMAN; PARTITION COEFFICIENT; PH; RAT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; CHEMISTRY; DRUG EFFECTS; LIME (FRUIT); MALE; SPRAGUE DAWLEY RAT;

ANIMALS; CITRUS AURANTIIFOLIA; FLAVONES; FRUIT; INTESTINAL ABSORPTION; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77958518632     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20101418     Document Type: Article

References (12)

1. Wang Xijun, Tetsuro Sakurai, Chen Xi, et al. Hydrolysis of flavanone glycosides and degradation of the corresponding aglycones from dried immature Citrus fruit by human fecal flora in vitro[J]. Planta Med,2000,279:1148.
2. Iris Erlund, Esa Meririnne, Georg Alfthan, et al. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice[J]. Hum Nutr Metab,2001,131:235.
3. Eun Ju Jeong, Xiaobin Jia, Ming Hu. Disposition of formononetin via enteric recycling: Metablism and excretion in mouse intestinal perfusion and caco-2 cell models[J]. Mol Pharm,2005,2(4):319.
4. Hu Ming, Gordon L Amidon. Passive and carrier-mediated intestinal absorption components of captopril[J]. J Pharm Sci,1988,77(12):1007.
5. Whocely Victor De Castro, Susanne Mertens Talcott, Hartmut Derendorf, et al. Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats[J]. J Agric Food Chem,2008,56:4840.
6. Lipinski C A, Lombardof, Dominy B W, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings[J]. Adv Drug Delivery Rev,1997,23:4.
7. H Serra, T Mendes, M R Bronze, et al. Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones[J]. Bioorg Med Chem,2008,16:4009.