Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach

Scandinavian Journal of Gastroenterology

Volumn 45, Issue 11, 2010, Pages 1273-1280

  Sakamoto, Hirotsugu ^a   Mutoh, Hiroyuki ^a   Sugano, Kentaro ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Cdx2; Claudin 2; Intestinal metaplasia

Indexed keywords

CLAUDIN 2; TRANSCRIPTION FACTOR CDX2;

ANIMAL TISSUE; ARTICLE; COLON; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; INTESTINE MUCOSA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; COLON; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; ILEUM; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; JEJUNUM; MEMBRANE PROTEINS; METAPLASIA; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PYLORIC ANTRUM; RNA; TRANSCRIPTION FACTORS;

EID: 77958515686     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2010.501522     Document Type: Article

References (28)

1. Meyer BI, Gruss P. Mouse cdx-1 expression during gastrulation. Development 1993;117:191-203.
2. Suh E, Chen L, Taylor J, Traber PG. A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol Cell Biol 1994;14:7340-7351
3. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996;16:619-625
4. Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, et al. Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa - with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer 2001;4:185-191
5. Eda A, Osawa H, Yanaka I, Satoh K, Mutoh H, Kihira K, Sugano K. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 2002;37:94-100.
6. SatohK,Mutoh H, Eda A, Yanaka I,Osawa H, Honda S, et al. Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori. Helicobacter 2002;7:192-198
7. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 2002;176:47-55.
8. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolos C, David L. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003;199:36-40.
9. Mutoh H, Hakamata Y, Sato K, Eda A, Yanaka I, Honda S, et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun 2002;294:470-479
10. Mutoh H, Satoh K, Kita H, Sakamoto H, Hayakawa H, Yamamoto H, et al. Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine. Int J Dev Biol 2005;49:867-871
11. Mutoh H, Sakurai S, Satoh K, Osawa H, Tomiyama T, Kita H, et al. Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. Gut 2005;54:33-39
12. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998;141:1539-1550
13. Rahner C,Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 2001;120: 411-422
14. Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000;118:1001-1011
15. Tsukita S, Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J Cell Biol 2000;149:13-16.
16. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001;2:285-293
17. Schneeberger EE, Lynch RD. Structure, function, and regulation of cellular tight junctions. Am J Physiol 1992;262: L647-61.
18. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995;269:G467-75.
19. Madara JL. Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 1998;60:143-159
20. Van Itallie C, Rahner C, Anderson JM. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 2001; 107:1319-1327
21. Simon DB, Lu Y, Choate KA, Velazquez H, Al-Sabban E, Praga M, et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science 1999; 285:103-106
22. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 1999;96:511-516
23. Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC. Cloning of the human claudin-2 5¢-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 2002;277:21361-21370
24. Escaffit F, Boudreau F, Beaulieu JF. Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 2005;203:15-26.
25. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25: 402-408
26. Troelsen JT, Mitchelmore C, Spodsberg N, Jensen AM, Noren O, Sjostrom H. Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem J 1997;322:833-838
27. Mutoh H, Sakamoto H, Hayakawa H, Arao Y, Satoh K, Nokubi M, Sugano K. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. Differentiation 2006;74: 313-321
28. Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, et al. Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci 2010;123:1913-1921.