Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats

Current Drug Delivery

Volumn 7, Issue 4, 2010, Pages 324-328

  Pabreja, Kavita ^a   Dua, Kamal ^a   Padi, Satyanaryana S V ^b  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b ISF COLLEGE OF PHARMACY   (India)

Author keywords

Hyperalgesia; Inflammation; NSAID; Topical

Indexed keywords

ACECLOFENAC; CARBOMER; CARRAGEENAN; MACROGOL; MACROGOL 400; MACROGOL 4000; METHYL PARABEN; N,N DIMETHYLFORMAMIDE; PROPYL PARABEN; TRIETHANOLAMINE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MANUFACTURE; FEMALE; GEL; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ACRYLIC RESINS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CHEMISTRY, PHARMACEUTICAL; DICLOFENAC; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; GELS; HYPERALGESIA; INFLAMMATION; MALE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR;

EID: 77958512867     PISSN: 15672018     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720110793360649     Document Type: Article

References (10)

1. Guy, R.H.; Maibach, H.I. Drug delivery to local subcutaneous structure following topical administration. J. Pharmacol. Sci., 1983, 72, 1375-1380.
2. Wildfang, I.L.; Maibach, H.I.; Famey, J.P.; Paulus, H.E. Topical application of NSAIDs. Therapeutic applications of NSAIDs. Marcel Dekker: New York, 1992.
3. Patel, N.A.; Patel, N.J.; Patel, R.P. Formulation and evaluation of curcumin gel for topical application. Pharm. Dev. Technol., 2009, 14(1), 80-89.
4. Singh, S.; Gajra, B.; Rawat, M.; Muthu, M.S. Enhanced transdermal delivery of ketoprofen from bioadhesive gels. Pak. J. Pharm. Sci., 2009, 22(2), 193-198.
5. Aukunuru, J.; Bonepally, C.; Guduri, V. Preparation, characterization and optimization of ibuprofen ointment intended for topical and systemic delivery. Trop. J. Pharm. Res., 2007, 6(4), 855-860.
6. Gupta, G.D.; Gaud, R.S. Antiinflammatory activity of tenoxicam gel on carrageenan-induced paw oedema in rats. Indian J. Pharm. Sci., 2006, 68, 356-359.
7. Padi, S. S.; Gupta, M.; Kehal, J. K.; Aggarwal, A.; Kumar R. K.; Marwaha Evaluation of topical gels containing non-steroidal anti-Inflammatory drugs on inflammation and hyperalgesia in rats. Int. J. Pharmacol., 2008, 6 (1).
8. Winter, C.A.; Risley, E.A.; Silber, R.H. Antiinflammatory activity of indomethacin and plasma corticosterone in rats. J. Pharmacol. Exp. Ther., 1968, 162, 196-201.
9. Troconiz, I.F.; Lopez-Bustamante, L.G.; Fos, D. Tenoxicam pharmacokinetics in rats: a population model. J. Pharm. Sci., 1995, 84(12), 1482-1487.
10. Kesavanarayanan, K.S.; Nappinnai, M.; Ilavarasan, R. Topical dosage form of valdecoxib: preparation and pharmacological evaluation. Acta. Pharm., 2007, 57(2), 199-209.