Is the presence of microalbuminuria a relevant marker of kidney disease?

Current Hypertension Reports

Volumn 12, Issue 5, 2010, Pages 364-368

  Glassock, Richard J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Albuminuria; All cause mortality; Cardiovascular events; Chronic kidney disease; End stage kidney disease; Estimated glomerular filtration rate; Microalbuminuria

Indexed keywords

CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISEASE; MICROALBUMINURIA; PATHOPHYSIOLOGY; PATIENT ASSESSMENT; REVIEW;

ALBUMINURIA; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CREATININE; DISEASE PROGRESSION; EARLY DIAGNOSIS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; RISK ASSESSMENT; SECONDARY PREVENTION;

EID: 77958506197     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-010-0133-3     Document Type: Review

References (35)

1. PA Svendsen B Oxenball JS Christiansen 1981 Microalbuminuria in diabetic patients-a longitudinal study Acta Endocrinol Suppl (Copenhagen) 242 53 54 1:STN:280:DyaL3M3gtlejuw%3D%3D
2. GC Viberti RD Hill RJ Jarrett, et al. 1982 Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus Lancet 1 1430 1432 1:STN:280:DyaL383hvVKhtg%3D%3D 10.1016/S0140-6736(82)92450-3 6123720
3. National Kidney Foundation 2002 Kidney Disease Outcomes Quality Initiative. Clinical Practice Guidelines for Chronic Kidney Disease; Evaluation, Classification and Stratification Am J Kidney Disease 39 Suppl 1 S1 S264
4. M Epstein 1996 Aging and the kidney J Am Soc Neprhol 7 1106 1122 1:STN:280:DyaK2s%2FhvF2ntQ%3D%3D
5. W Comper TM Osicka 2005 Detection of urinary albumin Adv Chronic Kidney Dis 12 170 176 10.1053/j.ackd.2005.01.012 15822052 (Pubitemid 40488999)
6. SO Leong KF Lui WY Ng AC Thai 1998 The use of semi-quantitative urine test-strip (Micral test) for microalbuminuria screening in patients with diabetes mellitus Singapore Med J 39 101 103 1:STN:280:DyaK1c3ps1Cnuw%3D%3D 9632966
7. PA Sarafidis J Riehle Z Bogojevic, et al. 2009 A comparative evaluation of various methods for microalbuminuria screening Am J Nephrol 28 324 329 10.1159/000111825
8. B Haraldsson J Nystrom WM Deen 2008 Properties of the glomerular barrier and mechanisms of proteinuria Physiol Rev 88 451 487 1:CAS:528: DC%2BD1cXls1Khs7k%3D 10.1152/physrev.00055.2006 18391170 (Pubitemid 351522745)
9. LM Russo RM Sandoval SB Campos, et al. 2009 Impaired tubular uptake explains albuminuria in early diabetic nephropathy J Am Soc Nephrol 20 489 494 10.1681/ASN.2008050503 19118149
10. LM Russo GL Bakris WD Comper 2002 Renal handling of albumin: a critical review of basic concepts and perspective Am J Kidney Dis 39 899 919 1:CAS:528:DC%2BD38XktFWms7s%3D 10.1053/ajkd.2002.32764 11979334 (Pubitemid 34460554)
11. I Bundschuh I Jackle-Meyer E Luneberg, et al. 1992 Glycation of serum albumin and its role in renal protein excretion and the development of diabetic nephropathy Eur J Chem Clin Biochem 30 651 656 1:CAS:528:DyaK3sXnvVCqug%3D%3D
12. MT James BR Hemmelgarn M Tonelli 2010 Early recognition and prevention of chronic kidney disease Lancet 375 1296 1309 1:CAS:528:DC%2BC3cXksFCltrw%3D 10.1016/S0140-6736(09)62004-3 20382326 This is a seminal review article that summarizes knowledge regarding detection and prevention of chronic kidney disease in a succinct and readable fashion
13. SI Hallan E Ritz S Lydersen, et al. 2009 Combining GFR and albuminuria to classify CKD improves prediction of ESRD J Am Soc Nephrol 20 1069 1077 1:CAS:528:DC%2BD1MXlvFKqtrc%3D 10.1681/ASN.2008070730 19357254 This is an excellent article that clearly shows the interactions between eGFR and albuminuria in determining risk for progressive kidney disease
14. BR Hemmelgarn BJ Manns A Lloyd, et al. 2010 Alberta Kidney Disease Network: Relation between kidney function, proteinuria and adverse outcomes JAMA 301 423 429 10.1001/jama.2010.39 This seminal article describes the relationship between eGFR and albuminuria or proteinuria and risk for cardiovascular events and progressive kidney disease
15. van der Velde M, de Jong PE, Gansevoort RT: Comparison of the yield of differing screening approaches to detect chronic kidney disease. Nephrol Dial Transplant 2010 (Epub ahead of print).
16. J Coresh E Selvin LA Stevens, et al. 2007 Prevalence of chronic kidney disease in the United States JAMA 298 2018 2047 10.1001/jama.298.17.2038 (Pubitemid 350074801)
17. Chronic Kidney Disease Prognosis Consortium 2010 Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis Lancet 375 2073 2081 10.1016/S0140-6736(10)60674-5 This landmark study involved a very large collection of databases and meta-analyses. It characterizes the relationships of eGFR and albuminuria or proteinuria and prognosis for all-cause mortality and cardiovascular mortality
18. Kalaitzidis RG, Bakris GL: Serum creatinine vs albuminuria as biomarkers for the estimation of cardiovascular risk. Curr Vasc Pharmacol 2010 (Epub ahead of print).
19. BA Perkins LH Ficociello KH Silva, et al. 2003 Regression of microalbuminuria in type 1 diabetes N Engl J Med 348 2285 2293 1:CAS:528:DC%2BD3sXkt1Kktrk%3D 10.1056/NEJMoa021835 12788992 (Pubitemid 36638102)
20. JM Steinke AR Sinaiko MS Kramer, et al. 2005 International Diabetic Nephropathy Study Group: The early natural history of nephropathy in type 1 diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients Diabetes 54 2164 2171 1:CAS:528: DC%2BD2MXmtVeltrg%3D 10.2337/diabetes.54.7.2164 15983218 (Pubitemid 40911280)
21. R Glassock 2010 Debate: CON position. Should microalbuminuria ever be considered as a renal endpoint in any clinical trial? Am J Nephrol 31 462 465 10.1159/000313553 20413961 This article forms part of a "debate" regarding the significance of microalbuminuria as a surrogate end point in prospective clinical trials
22. AK Bello D de Zeeuw M El Nahas, et al. 2007 Impact of weight change on albuminuria in the general population Nephrol Dial Transplant 22 1619 1627 1:CAS:528:DC%2BD2sXot1Sgs7s%3D 10.1093/ndt/gfm091 17360767 (Pubitemid 47073760)
23. H Vlassara M Torreggiani JB Post, et al. 2009 Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging Kidney Int Suppl 114 S3 S11 1:CAS:528:DC%2BD1MXhsV2hurnM 10.1038/ki.2009.401 19946325
24. BA Perkins LH Ficociello B Roshan, et al. 2010 In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria Kidney Int 77 57 64 1:CAS:528:DC%2BD1MXhsFGms7rN 10.1038/ki.2009.399 19847154
25. M Mauer B Zinman R Gardiner, et al. 2009 Renal and retinal effects of enalapril and losartan in type 1 diabetes N Engl J Med 361 40 51 1:CAS:528:DC%2BD1MXotV2hu70%3D 10.1056/NEJMoa0808400 19571282
26. H Ito Y Takeuchi H Ishida, et al. 2010 High frequencies of diabetic micro- and macroangiopathies in patients with type 2 diabetes mellitus with decreased estimated glomerular filtration rate and normoalbuminuria Nephrol Dial Transplant 25 1161 1167 1:CAS:528:DC%2BC3cXjvF2htLk%3D 10.1093/ndt/gfp579 19892756
27. GL Bakris PA Sarafidis MR Weir, et al. 2010 ACCOMPLISH Trial Investigators: Renal outcomes with different fixed dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised clinical trial Lancet 375 1173 1181 1:CAS:528:DC%2BC3cXktlGitr8%3D 10.1016/S0140-6736(09)62100-0 20170948 This seminal clinical trial showed that a change in microalbuminuria can be dissociated from renal outcomes with fixed-dose combined therapy in high-risk patients
28. V Lorenzo R Saracho J Zamora, et al. 2010 Similar renal decline in diabetic and non-diabetic patients with comparable degrees of albuminuria Nephrol Dial Transplant 25 835 841 1:CAS:528:DC%2BC3cXislajsbg%3D 10.1093/ndt/gfp475 19762600
29. P de Jong RT Gansevoort 2010 Albuminuria in non-primary renal disease: risk marker rather than risk factor Nephrol Dial Transplant 25 656 658 10.1093/ndt/gfp691 20037170 This article provides a nice critical review of the status of microalbuminuria as a risk factor or risk marker
30. SW Choi WJ Yun HY Kim, et al. 2010 Association between albuminuria, carotid atherosclerosis, arterial stiffness and peripheral artery disease in Korean type 2 diabetic patients Kidney Blood Press Res 33 111 118 1:CAS:528:DC%2BC3cXntFSjtbs%3D 10.1159/000313594 20431302
31. MD Solbu TG Jenssen BO Eriksen I Toft 2009 Changes in insulin sensitivity, renal function and markers of endothelial dysfunction in hypertension-the impact of microalbuminuria: a 13 year follow-up study Metabolism 58 408 415 1:CAS:528:DC%2BD1MXitVClsbw%3D 10.1016/j.metabol.2008.10. 016 19217459
32. Silva AM, Schaan BD, Signori LU, et al.: Microalbuminuria is associated with impaired arterial and venous endothelium dependent vasodilation in patients with type 2 diabetes. J Endocrinol Invest 2010 (Epub ahead of print).
33. MC Foster MJ Keyes MG Larson, et al. 2008 Relations of measures of endothelial function and kidney disease: the Framingham Heart Study Am J Kidney Dis 52 859 867 10.1053/j.ajkd.2008.04.027 18617305
34. DE Rifkin R Katz M Chonchoi, et al. 2010 Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly Nephrol Dial Transplant 25 1560 1567 1:CAS:528:DC%2BC3cXlt1CjsLw%3D 10.1093/ndt/gfp646 20008829
35. J Bielby ML Divitini MW Knuiman, et al. 2010 Comparison of cystatin C and creatinine as predictors of cardiovascular events in a community-based elderly population Clin Chem 56 799 804 10.1373/clinchem.2009.135962