Does oxidative DNA damage cause atherosclerosis and metabolic syndrome?: New insights into which came first: The chicken or the egg

Circulation Research

Volumn 107, Issue 8, 2010, Pages 940-942

  Madamanchi, Nageswara R ^a   Zhou, Rui Hai ^a   Vendrov, Aleksandr E ^a   Niu, Xi Lin ^a   Runge, Marschall S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ATHEROSCLEROTIC PLAQUE; CORONARY ARTERY ATHEROSCLEROSIS; DNA DAMAGE; DNA REPAIR; GENE MUTATION; GENOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MACROPHAGE; METABOLIC SYNDROME X; NONHUMAN; NOTE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; ULTRAVIOLET IRRADIATION;

ATHEROSCLEROSIS; DNA DAMAGE; HUMANS; METABOLIC SYNDROME X; OXIDATIVE STRESS;

EID: 77958501861     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.230904     Document Type: Note

References (15)

1. Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res. 2010;107:1021-1031.
2. Madamanchi NR, Runge MS. Mitochondrial dysfunction in atherosclerosis. Circ Res. 2007;100:460-473.
3. Ballinger SW, Patterson C, Knight-Lozano CA, Burow DL, Conklin CA, Hu Z, Reuf J, Horaist C, Lebovitz R, Hunter GC, McIntyre K, Runge MS. Mitochondrial integrity and function in atherogenesis. Circulation. 2002; 106:544-549.
4. Satoh M, Ishikawa Y, Takahashi Y, Itoh T, Minami Y, Nakamura M. Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease. Atherosclerosis. 2008; 198:347-353.
5. Roos WP, Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med. 2006;12:440-450.
6. Rasmussen AK. Identification of factors interacting with hMSH2 and HMLH1 in the fetal liver and investigations of how mitochondrial dysfunction creates a mutator phenotype. Dissertation. Roskilde, Denmark: Roskilde University; 2001. Available at: http://hdl.handle.net/1800/458.
7. Rasmussen AK, Chatterjee A, Rasmussen LJ, Singh KK. Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. Nucleic Acids Res. 2003;31:3909-3917.
8. Corral-Debrinski M, Shoffner JM, Lott MT, Wallace DC. Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res. 1992;275:169-180.
9. Ballinger S, Patterson C, Yan C, Doan R, Burow D, Young C, Yakes F, van Houten B, Ballinger C, Freeman B, Runge M. Hydrogen peroxide and peroxynitrite inducedmitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res. 2000;86: 960-966.
10. Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, Ballinger SW. Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol. 2009;297: L209-L216.
11. Schalch DS, McFarlin DE, Barlow MH. An unusual form of diabetes mellitus in ataxia telangiectasia. N Engl J Med. 1970;282:1396-1402.
12. Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, Bernal-Mizrachi C, Muslin AJ, Kastan MB, Semenkovich CF. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 2006;4:377-389.
13. Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest. 2007;117:2723-2734.
14. Miles PD, Treuner K, Latronica M, Olefsky JM, Barlow C. Impaired insulin secretion in a mouse model of ataxia telangiectasia. Am J Physiol Endocrinol Metab. 2007;293:E70-E74.
15. Halaby MJ, Hibma JC, He J, Yang DQ. Cell Signal. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 trans-location by insulin in muscle cells. Cell Signal. 2008;20:1555-1563.