Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation

Applied Radiation and Isotopes

Volumn 68, Issue 9, 2010, Pages 1595-1601

  Bonardi, M L ^a   Groppi, F ^a   Manenti, S ^a   Persico, E ^a   Gini, L ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Cyclotron; Metabolic radiotherapy; Natural W and enriched W 186; Proton and deuteron irradiations; Radionuclidic purity; Rhenium 186g; Specific activity

Indexed keywords

ACCURACY AND PRECISION; BEAM ENERGIES; EXCITATION FUNCTION; ISOTOPIC COMPOSITION; METASTABLE LEVELS; NATURAL W AND ENRICHED W-186; RADIONUCLIDIC PURITY; REACTION CROSS-SECTIONS; RHENIUM-186G; SPECIFIC ACTIVITY; THICK TARGET YIELD;

CYCLOTRONS; DEUTERIUM; IRRADIATION; NUCLEAR PHYSICS; PROTONS; RHENIUM; TANTALUM;

TUNGSTEN;

RHENIUM 186; DEUTERIUM; PROTON; RADIOISOTOPE; RHENIUM;

ACCURACY; DEUTERON CYCLOTRON IRRADIATION; PARTICLE RADIATION; PHYSICAL PARAMETERS; PRIORITY JOURNAL; PROTON RADIATION; RADIATION ENERGY; RADIATION MEASUREMENT; RADIOACTIVITY; RELIABILITY; REVIEW; THICK TARGET YIELDS; ARTICLE; CHEMISTRY; CYCLOTRON; ISOTOPE LABELING; METHODOLOGY; RADIATION DOSE; RADIATION EXPOSURE;

CYCLOTRONS; DEUTERIUM; ISOTOPE LABELING; PROTONS; RADIATION DOSAGE; RADIOISOTOPES; RHENIUM;

EID: 77958479416     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2010.03.014     Document Type: Review

References (43)

1. Alberti G., Birattari C., Bonardi, M., Groppi F., 1992. Multiple scattering and thermal dissipation of charged particle beams in multiple thin metallic targets. In: Proceedings of the. Fourth Workshop on Targetry and Target Chemistry, PSI, Villigen, Switzerland, September 1991, PSI Ed., pp. 89-95.
2. Alfassi Z.B., Persico E., Groppi F., Bonardi M.L. On the photon self-absorption correction for thin-target-yields vs. thick-target-yields in radionuclide production. Appl. Radiat. Isot. 2009, 240-242.
3. Audi G., Wapstra A.H., Thibault C. The AME2003 atomic mass evaluation (II). Tables, graphs and references. Nucl. Phys. A 2003, 729:337-676.
4. 186gRe]Re - HEDP for bone metastases pain palliation. J. Radioanal. Nucl. Chem. 2005, 263:515-520.
5. Basile D., Birattari C., Bonardi M., Goetz L., Sabbioni E., Salomone A. Excitation functions and production of arsenic radioisotopes for environmental toxicology and biomedical purposes. Int. J. Appl. Radiat. Isot. 1981, 32:403-410.
6. Birattari C., Castiglioni M., Silari M. Absolute calibration of accelerator beam energies by the crossover technique. Nucl. Instr. Meth. A 1992, 320:413-431.
7. Bonardi, M.L., 1988. The contribution to nuclear data for biomedical radioisotope production from the Milan Cyclotron Laboratory. IAEA Consultant's meeting on Nuclear Data Requirements for medical radioisotope production, Tokyo, April 1987, INDC(NDS)-195/GZ, IAEA, Vienna, Austria, 98-112.
8. Bonardi M.L., Birattari C., Groppi F., Gini L., Mainardi C.H.S. Cyclotron production and quality control of "high specific activity" radionuclides in "no-carrieradded" form for radioanalytical applications in the life sciences. J. Radioanal. Nucl. Chem. 2004, 259:415-419.
9. 94g;95m;95g;96(m+g)Tc nuclear reactions induced by protons from threshold up to 44 MeV. No Carrier Added radiochemical separation and quality control. Appl. Radiat. Isot. 2002, 57:617-635.
10. Bonardi M.L., de Goeij J.J.M. How do we ascertain specific activities in no-carrieradded radionuclide preparations?. J. Radioanal. Nucl. Chem. 2005, 263:87-92.
11. Bonardi M., Groppi F., Birattari C., Alberti G. MSCT and HEAT: computer codes for simulation of multiscattering and thermal dissipation of charged particle beams in multiple thin metallic targets. J. Label. Cpd. Radiopharm 1989, 26:185-188.
12. Bonardi M.L., Groppi F., Birattari C., Mainardi C.H.S. Thin-target excitation functions: a powerful tool for optimising yield, specific activity and radionuclidic purity of accelerator-produced radionuclides. Czech. J. Phys. 2003, 53(Suppl. A):A393-A403.
13. Bonardi, M.L., Groppi, F., Persico, E., Quartapelle, E., Gandini, A., Marchetti, M., Manenti, S., 2008. Radiochemical Separation and quality control of high specific activity Re-186g in no-carrier-added form from cyclotron irradiated W and W-186 targets. In: Proceedings of the Seventh International Conference on Nuclear Radiochemistry - NRC7, Budapest, Hungary.
14. Bonardi M., Silari M. Fundamental parameters for the optimization of yield and radionuclidic purity of accelerator produced radioisotopes. Part II: beam control and monitoring. Phys. Med. 1988, 2:83-101.
15. Boswell C.A., Brechbie M.W. Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view. Nucl. Med. Biol. 2007, 34:757-778.
16. Choppin G., Liljenzin J.O., Rydberg J. Radiochemistry and Nuclear Chemistry 2002, Butterworth-Heinemann, USA. 3rd ed.
17. Debertin, K., Helmer, R.G., 1988. Gamma- and X-ray spectrometry with semiconductor detectors. North-Holland.
18. de Goeij J.J.M., Bonardi M.L. How do we define the concepts specific activity, radioactive concentration, carrier, carrier-free and no-carrier-added?. J. Radioanal. Nucl. Chem. 2005, 263:13-18.
19. Demildt A. Excitation functions of (d,α) and (d, αn) reactions on tungsten. J. Inorg. Nucl. Chem. 1961, 23:167-171.
20. Eckelman W.C., Bonardi M., Volkert W.A. True radiotracers: are we approaching theoretical specific activity with Tc-99m and I-123?. Nucl. Med. Biol. 2008, 35:523-527.
21. Finlay I.G., Mason M.D., Shelley M. Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncol. 2005, 6:392-400.
22. Firestone R.B., Baglin C.M., Chu F.S.Y. Tableof Isotopes 1998, John Wiley & Sons, New York, USA, 1998 Update on CD-ROM. 8th Ed.
23. Gilmore G.R. Practical Gamma Ray Spectroscopy 2008, John Wiley & Sons, England. 2nd ed.
24. Groppi F., Bonardi M.L., Menapace E., Morzenti S., Zona C., Canella L., Alfassi Z.B. Results on accelerator production of innovative radionuclides for metabolic radiotherapy and PET and on related nuclear data. Nucl. Instr. Meth. A 2006, 562:1072-1075.
25. 131I-counterpart. Cancer Lett. 2005, 219:41-48.
26. Liu S. Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides. Adv. Drug Delivery Rev. 2008, 60:1347-1370.
27. Magill, J., Pfennig, G., Galy, J., 2006. Karlsruher Nuklidkarte. European Commission, Joint Research Center, Report EUR 22276 EN.
28. Marion J.B., Zimmerman B.A. Multiple scattering of charged particles. Nucl. Instr. Meth. 1967, 51:93-101.
29. 188Re for the labeling of bombesin. Nucl. Med. Biol. 2006, 33:81-89.
30. Olivier P. Nuclear oncology, a fast growing field of nuclear medicine. Nucl. Instr. Meth. Phys. Res. A 2004, 527:4-8.
31. Pages L., Bertel E., Joffre H., Sklavenitis L. Energy loss, range, and bremsstrahlung yield for 10-keV to 100-MeV electrons in various elements and chemical compounds. At. Data 1972, 4:1-127.
32. Qaim S.M. Therapeutic radionuclides and nuclear data. Radiochim. Acta 2001, 89:297-302.
33. Rösch F. Radiochemistry and Radiopharmaceutical Chemistry in Life Sciences. Handbook of Nuclear Chemistry 2003, vol. 4. Kluwer Academic, The Netherlands.
34. Rossi B., Greisen K. Cosmic-ray theory. Rev. Mod. Phys. 1941, 13:240-309.
35. Sharkey R.M., Goldenberg D.M. Use of antibodies and immunoconjugates for the therapy of more accessible cancers. Adv. Drug Deliv. Rev. 2008, 60:1407-1420.
36. 186Re]Liposomal doxorubicin (Doxil): in vitro stability, pharmacokinetics, imaging and biodistribution in a head and neck squamous cell carcinoma xenograft model. Nucl. Med. Biol. 2009, 36:515-524.
37. Stöcklin G., Qaim S.M., Rösch F. The impact of Radioactivity on Medicine. Radiochim. Acta 1995, 70/71:249-272.
38. Tárkányi F., Takács S., Szelecsényi F., Ditrói F., Hermanne A., Sonck M. Excitation functions of deuteron induced nuclear reactions on natural tungsten up to 50MeV. Nucl. Instr. Meth. Phys. Res. A 2003, 211:319-330.
39. Taylor, B.N., Kuyatt C.E., 1994. Guidelines for Evaluating and Expressing the Uncertainty of NIST Measurement Results - NIST-TN-1297. http://physics.nist.gov/cuu/Uncertainty/bibliography.htm.
40. Wong J.Y.C. Basic immunology of antibody targeted radiotherapy. Int. J. Rad. Oncol. Biol. Phys. 2006, 66(2):S8-S14.
41. Wong J.Y.C. Basic Systemic targeted radionuclide therapy: Potential new areas. Int. J. Rad. Oncol. Biol. Phys. 2006, 66(2):S74-S82.
42. 186Re reaction. Radiochim. Acta 1999, 86:11-16.
43. Ziegler J.F., Bierzack J.P., Littmark U. The Stopping and Range of Ions in Matter. SRIM-2008 2008, 01. 〈http://www.SRIM.org〉.