Increased cardiac risk in concomitant methadone and diazepam treatment: Pharmacodynamic interactions in cardiac ion channels

Journal of Cardiovascular Pharmacology

Volumn 56, Issue 4, 2010, Pages 420-430

  Kuryshev, Yuri A ^a   Bruening Wright, Andrew ^a   Brown, Arthur M ^a   Kirsch, Glenn E ^a  

^a ChanTest Corporation   (United States)

Author keywords

automated patch clamp; cardiac ion channels; diazepam; hERG; methadone; stem cell derived human cardiomyocytes; transfected mammalian cells

Indexed keywords

DIAZEPAM; METHADONE; POTASSIUM CHANNEL KV4.3; SODIUM CHANNEL NAV1.5; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL CAV1.2; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; PATCH CLAMP; PRIORITY JOURNAL; QT INTERVAL; STEM CELL;

ACTION POTENTIALS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; HYPNOTICS AND SEDATIVES; ION CHANNELS; KCNQ1 POTASSIUM CHANNEL; KV CHANNEL-INTERACTING PROTEINS; METHADONE; MUSCLE PROTEINS; MYOCYTES, CARDIAC; NARCOTICS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SODIUM CHANNELS;

EID: 77958467760     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181f1d21b     Document Type: Article

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