Determining times to maximum urine excretion of 1-aminopyrene after diesel exhaust exposure

Journal of Exposure Science and Environmental Epidemiology

Volumn 20, Issue 7, 2010, Pages 650-655

  Huyck, Susan ^a   Ohman Strickland, Pamela ^a,b   Zhang, Lin ^a   Tong, Jian ^a   Xu, Xu ^a,c   Zhang, Junfeng ^a,b  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

1 aminopyrene; diesel exhaust; time of maximum excretion; urine biomonitoring

Indexed keywords

1 AMINOPYRENE; 1-AMINOPYRENE; BIOLOGICAL MARKER; PYRENE DERIVATIVE;

ARTICLE; ENVIRONMENTAL MONITORING; EXHAUST GAS; EXPOSURE; HUMAN; METHODOLOGY; TIME; URINE;

BIOLOGICAL MARKERS; ENVIRONMENTAL MONITORING; HUMANS; INHALATION EXPOSURE; PYRENES; TIME FACTORS; VEHICLE EMISSIONS;

EID: 77958462123     PISSN: 15590631     EISSN: 1559064X     Source Type: Journal    
DOI: 10.1038/jes.2010.29     Document Type: Article

References (11)

1. Bamford H.A., Bezabeh D.Z., Schantz S., Wise S.A., and Baker J.E. Determination and comparison of nitrated-polycyclic aromatic hydrocarbons measured in air and diesel particulate reference materials. Chemosphere 2003: 50: 575-587.
2. Barr D.B., Wang R.Y., and Needham L.L. Biologic monitoring of exposure to environmental chemicals throughout the life stages: requirements issues for consideration for the National Children's Study. Environ Health Perspect 2005: 113(8): 1083-1091.
3. Battelle Pacific, Northwest Laboratories, 1991. NTP technical study report on toxicity studies of 1-nitropyrene. Report no. 34, United States Department of Health Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC, April 1996.
4. El-Bayoumy K., Sharma C., Louis Y.M., Reddy B., and Hecht S.S. The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional germfree rats in humans. Cancer Lett 1983: 19: 311-316.
5. IPCS Inchem, 2003. http://www.inchem.org/documents/ehc/ehc/ehc229.htm. (accessed 20 April 2010).
6. Laumbach R., Tong J., Zhang L., Ohman-Strickland P., Stern A., and Fiedler N., et al. Quantification of 1-aminopyrene in human urine after a controlled exposure to diesel exhaust. J Environ Monit 2009: 11: 153-159.
7. Saito K., Kamataki T., and Kato R. Participation of cytochrome P-450 in reductive metabolism of 1-nitropyrene by rat liver microsomes. Cancer Res 1984: 44: 3169-3173.
8. SAS Institute Inc. SAS Online Doc Version 9.1.. SAS Institute Inc, Cary, NC, 2004.
9. Seidel A., Dahmann D., Krekeler H., and Jacob J. Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust. Int J Hyg Environ Health 2002: 204: 333-338.
10. Shargel L., and Yu A.B.C. Applied Biopharmaceutics Pharmacokinetics. Appleton and Lang, Stamford, CT, 1993.
11. Zwirner-Baier I., and Neumann H.G. Polycyclic nitroarenes (nitro-PAHs) as biomarkers of exposure to diesel exhaust. Mutat Res 1999: 441: 135-144.