Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones

Cellular Immunology

Volumn 266, Issue 1, 2010, Pages 1-6

  Franco, Alessandra ^a   Almanza, Gonzalo ^b   Burns, Jane C ^a   Wheeler, Matthew ^b   Zanetti, Maurizio ^b  

^a RADY CHILDREN'S HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

ER stress; Human T cell clones; Immune regulation; Kawasaki disease; Tregs

Indexed keywords

INITIATION FACTOR 2ALPHA; INTERLEUKIN 10; SALUBRINAL; THAPSIGARGIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; DEPHOSPHORYLATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CINNAMATES; CLONE CELLS; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-23 SUBUNIT P19; MUCOCUTANEOUS LYMPH NODE SYNDROME; STRESS, PHYSIOLOGICAL; T-LYMPHOCYTES, REGULATORY; THAPSIGARGIN; THIOUREA; TRANSCRIPTION FACTOR CHOP; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EUKARYOTA;

EID: 77958459024     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.09.006     Document Type: Article

References (20)

1. Wheeler M.C., Rizzi M., Sasik R., Almanza G., Hardiman G., Zanetti M. KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity. J. Immunol. 2008, 181:256-264.
2. Scheu S., Stetson D.B., Reinhardt R.L., Leber J.H., Mohrs M., Locksley R.M. Activation of the integrated stress response during T helper cell differentiation. Nat. Immunol. 2006, 7:644-651.
3. + T cell differentiation during acute infection. J. Immunol. 2008, 181:5433-5441.
4. Franco A., Shimizu C., Tremoulet A.T., Burns J.C. Memory T-cells and characterization of peripheral T cell clones in acute Kawasaki disease. Autoimmunity 2010, 43:317-324.
5. Brown J.T., Crawford S.E., Cornwall M.L., Garcia F., Shulman S.T., Rowley A.H. CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease. J. Infect. Dis. 2001, 184:940-943.
6. Newburger J.W., Takahashi M., Gerber M.A., Gewitz M.H., Tani L.Y., Burns J.C., Shulman S.T., Bolger A.F., Ferrieri P., Baltimore R.S., Wilson W.R., Baddour L.M., Levison M.E., Pallasch T.J., Falace D.A., Taubert K.A. Diagnosis, treatment and long term management of Kawaski disease: a statement for health professionals from the Committee for Rheumatic Fever, Endocarditis and Kawaski Disease, Council on Cardiovascular Diseases in the Young, American Heart Association. Circulation 2004, 110:2747-2771.
7. Boyce M., Bryant K.F., Jousse C., Long K., Harding H.P., Scheuner D., Kaufman R.J., Ma D., Coen D.M., Ron D., Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005, 307:935-939.
8. + CD25-Foxp3-Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Experimental Medicine 2007, 204:285-297.
9. + (Foxp3) regulatory T cells in human visceral leishmaniasis. J. Exp. Med. 2007, 204:805-817.
10. O'Garra A., Vieira P. Th1 cells control themselves by producing IL-10. Nat. Rev. 2007, 7:425-428.
11. Trinchieri G. Interleukin-10 production by effector cells: Th1 cells show self control. J. Exp. Med. 2007, 204:239-243.
12. Stritesky G.L., Yeh N., Kaplan M.H. IL-23 promotes maintenance but not commitment to the Th17 lineage. J. Immunol. 2008, 181:5948-5955.
13. Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 2002, 3:643-651.
14. Zhao K., Wang W., Rando O.J., Xue Y., Swiderek K., Kuo A., Crabtree G.R. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 1998, 95:625-636.
15. R. Tao, E.F. de Zoeten, E. Ozkaynak, C. Chen, L. Wang, P.M. Porrett, B. Li, L.A. Turka, E.N. Olson, M.I. Greene, A.D., Wells, and W.W. Hancock, Deacetylase inhibition promotes the generation and function of regulatory T cells, Nat. Med. 13 (2007) 1299-1307.
16. Li B., Samanta A., Song X., Iacono K.T., Bembas K., Tao R., Basu S., Riley J.L., Hancock W.W., Shen Y., Saouaf S.J., Greene M.I. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc. Natl Acad. Sci. USA 2007, 104:4571-4576.
17. Pellicciotta I., Cortez-Gonzalez X., Sasik R., Reiter Y., Hardiman G., Langlade-Demoyen P., Zanetti M. Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. Cancer Res. 2008, 68:8085-8093.
18. Platzer C., Meisel C., Vogt K., Platzer M., Volk H.D. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Int. Immunol. 1995, 7:517-523.
19. Bettelli E., Dastrange M., Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl Acad. Sci. USA 2005, 102:5138-5143.
20. F. Martinon, X. Chen, A.H. Lee, and L.H. Glimcher, TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat. Immunol. 11 411-418.